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The benefit decreased under the conditions of a stress test. CBD has also shown promise in mood management (see below). Mood plays a key role in the regulation of blood pressure.

CBD also has antioxidant properties, which have been shown in animal tests to reduce cardiovascular cell death and inflammation. A study of diabetic mice showed that doses of CBD correlated with a 56% reduction in inflammation due to diabetes. Both type 1 and type 2 diabetes are risk factors in the development of chronic kidney disease—one of the reasons why diabetes is such a serious condition. Diabetes is an inflammatory condition that affects the body’s ability to regulate blood sugar. Management of lifestyle factors, including diet, play a big role in the prevention and management of the condition. The ability of CBD to reduce inflammation and manage the appetite may contribute to the prevention of type 2 diabetes, and possibly to the management of the symptoms of type 1 and type 2 diabetes.

Several animal studies have demonstrated the promise of CBD to reduce symptoms of depression and anxiety. This is possibly due to the ability of the endocannabinoid system to regulate internal homeostasis, including those impacting mood. Mood plays a key role in the regulation of blood pressure. High blood pressure is a major risk factor for the development of chronic kidney disease. More importantly for people who already have kidney failure, treatments like dialysis have a major impact on the patient’s quality of life. Long waits on kidney donor lists can lead to anxiety. CBD and kidney disease could be a match if for no other reason than CBD’s potential ability to improve how patients cope with a tough diagnosis and treatment regimen. As mentioned, the endocannabinoid system helps the body maintain internal balance. Proper kidney function plays a big role in that internal balance. If CBD stimulates the production of natural cannabinoids that bind to CB1 and CB2 receptors, it could improve kidney function, preventing chronic kidney disease or alleviating the symptoms of other kidney conditions. Why More Research is Needed Around CBD and Kidney Disease. As you probably know, cannabis products have been heavily stigmatized and, until recently, widely criminalized in the US and many parts of the world. Cannabis is still illegal in a number of countries, and marijuana and THC are illegal in the US at the federal level. While restrictions on cannabinoids like CBD have been relaxed, their widespread acceptance lags far behind other compounds, many of which have enjoyed years or even decades of scientific testing. Cannabis has hundreds of years of folkloric medicine and anecdotal evidence that may attest to its effectiveness in certain health conditions, but the number of modern, scientific trials available for peer review are few and far between, partially due to the stigma and the illegality. What studies do exist suffer from many limitations, including: Studies of animals and not humans. Focused on alternate cannabinoids like THC or synthetic THC cannabinoids. To earn widespread acceptance as an effective treatment, the interaction of CBD and kidney disease needs much more clinical study. These studies must be double-blind controlled, study a large sample size of human patients, focus on CBD, and demonstrate consistent results to be scientifically relevant. Additionally, studies must address the health risks of various forms of CBD ingestion. Smoking of CBD-rich marijuana or vaporized CBD oil may impair lung function at the same time as it alleviates renal symptoms. Sugary CBD edibles or beverages may worsen diabetes, high blood pressure, or heart disease. The interaction of CBD with other medications, including kidney disease medications, also needs further study.

Doctors are also working to better understand the side effects of CBD, its effect on the endocannabinoid system, and the way it might differently affect people in different demographics, including factors of age and other medical conditions. Anecdotal and folkloric reputation doesn’t cut it when it comes to FDA approval and other markers of legitimacy. CBD has no proven direct effect on the underlying causes of kidney disease. The potential benefits of CBD currently focus on the management of symptoms and secondary conditions. While more testing is needed—probably years’ worth of testing—there may nevertheless not be sufficient reason to wait. The widespread decriminalization of CBD attests to a profile thus far of safety and potential. Most experts agree that there is little risk to patients with kidney disease trying CBD as a supplemental treatment. It is not a replacement for dialysis and prescribed medication. However, for patients in search of relief for symptoms, CBD may check many of the relevant boxes based on early trials.

Some experts also see the potential use of CBD for kidney disease as part of a much-needed movement toward acceptance of cannabinoids and their medicinal properties, opening the door for more conclusive studies. However, with few attractive treatment options and uncertain prognosis, CBD may be worth a try for the alleviation or reduction of some symptoms. You will receive an email shortly at: Here at, we are committed to protecting your privacy.


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