Categories
BLOG

biocare cbd oil

Everything you need to know about CBD

Are you seeing CBD products everywhere at the moment but feel unsure of what it actually is, whether it really lives up to all the hype, and how it could help you? If so, we’ve written this blog with you in mind. Read on to have all of your questions answered!

CBD – THE BASICS

‘CBD’ stands for cannabidiol. Cannabidiol is one of 100+ compounds which are collectively known as cannabinoids. Cannabinoids are naturally abundant in species of the plant genus Cannabis, of which Cannabis sativa is the most widely utilised. Interestingly, Cannabis plants have two genders, male and female, and both are quite distinct in their characteristics and usage:

  • Female type – grown for recreational drug and medical purposes (aka marijuana or medical cannabis).
  • Male type – grown for their highly nutritious seeds and fibre (aka industrial hemp). [1]

The key difference between them is how much ∆ 9 -tetrahydrocannabinol (∆ 9 -THC) they contain. ∆ 9 -THC is a cannabinoid with psychoactive properties which is responsible for the physiological effects of cannabis as a drug. The female types have a high content of THC ∆ 9 -THC, while the male types are low in ∆ 9 -THC.

Crucially, the oil extracted from hemp seeds is rich in CBD. In stark contrast to ∆ 9 -THC, CBD does not possess any psychoactive, intoxicating effects. On this basis, it is legal as a food supplement in the UK (and some other countries) as long as the product in question can be demonstrated to contain 9 -THC and CBD led to discovery of a previously unknown biochemical communication network called the endocannabinoid system (ECS) which is thought to regulate a number of physiological functions including nervous system, mood and cognition, immunity, as well as feeding behaviour.

It is made up of cannabinoid molecules that we make ourselves termed endocannabinoids, which act in a similar way to neurotransmitters, cannabinoid receptors (e.g. CB1, CB2), and the enzymes responsible for making and breaking down endocannabinoids. [2] Cannabinoid receptors are widely expressed throughout our body, particularly in the central nervous system (CNS) and on immune cells, [3], [4]

CBD has a wide spectrum of action with multiple beneficial effects on health. Research in this area continues to develop at pace! [5], [6]

TOP 3 AREAS SUPPORTED BY CBD

1. NERVOUS SYSTEM RESILIENCE

This is one of the hottest areas of research for CBD at the moment, with a particular focus on mental [7] and neurological [8] health.

Animal studies have highlighted its potential for depression through possible stimulation of the serotonin receptor. [9] Supplementation with straight CBD oil at dosages between 25-600mg [10] , [11] , [12] ) may reduce anxiety and sleep complaints. [13] Clinical benefits have also been observed for psychosis, [14] for example at 800mg/day for those with schizophrenia, [15] potentially by normalising activity in certain brain regions. [16]

Even wider potential of CBD for nervous system disorders has been revealed in recent years:

  • Parkinson’s – may reduce tremor severity, [17] potentially by protecting the dopamine-producing neurons from toxin-induced damage according to in vitro research. [18]
  • Multiple sclerosis (MS) – may help to improve symptom severity, including mobility. [19] In vitro research indicates that CBD may protect the cells that are involved in the myelination of neurons. [20]
  • Alzheimer’s disease – may tackle several underlying drivers of this condition, including oxidative stress, inflammation, and plaque formation, according to in vitro research. [21]

2. STRENGTH & BALANCE OF THE IMMUNE SYSTEM

The antioxidant and anti-inflammatory properties of CBD indicate that it could be a powerful adjunct for the natural management of a wide variety of conditions, given that chronic oxidative stress and inflammation are major drivers of many of the diseases prevalent today, including diabetes and disorders of the cardiovascular system. [22] With regards to the latter, animal research indicates that CBD can protect blood vessels from damage through its ability to combat free radicals and modulate inflammation, and go on to support blood vessel relaxation too. [23]

3. PAIN MANAGEMENT

Another important application is pain management. The Global Burden of Disease Study 2016 estimated that pain and pain-related diseases are amongst the leading causes of disability and disease burden globally. [24] CBD has reported pain-relieving properties. For instance, a hemp extract providing

30mg CBD/day has been shown to improve chronic pain, sleep quality, reduce opiod use, and improve quality of life amongst chronic pain patients. [25] The mode of action is thought to involve its ability to modulate inflammation and pain receptor channels. [26] This function highlights the potential utility of CBD for any condition where chronic pain is an issue.

POOR CBD BIOAVAILABILITY – THE MOST PRACTICAL SOLUTION

CBD really is worth all of the hype, but it has a quirk! When occurring naturally in hemp oil, or simply extracted from it, CBD has poor bioavailability in humans, especially when consumed orally due to challenges with absorption in the gut and extensive metabolism by the liver. The dose which reaches general circulation can be as low as 6% of the amount that you consumed, [27] , [28] which is a big issue when supplementing with CBD and wanting to see results!

One solution is to administer large oral dosages to increase the chance that enough will reach circulation to exert a benefit. This is the approach taken by most researchers, as you can see from the research referenced above.

An alternative solution is to administer lower oral dosages of a more bioavailable form of CBD which harnesses the power of cutting-edge liposomal technology. This type of CBD may be 4x better absorbed than other oils and have an up to 3x longer-lasting effect. [29] The beauty of delivering CBD with superior bioavailability means that a lower daily dosage of CBD can have maximum effect. In fact, if liposomal CBD is around 4x better absorbed than standard, a 10mg daily dosage of liposomal CBD may deliver the biological activity of 40mg straight CBD, so it’s a far smarter way of supplementing CBD. Our view is that this latter solution is the most practical and cost-effective way of supplementing with CBD in a real-life setting.

If you are keen to discuss CBD, we encourage you to call or email our Clinical Nutrition team who are here to support you.

Got a question?

The brand you can talk to:

We have a team of Nutritionists at the end of our advice line, open to you, for product support and advice (5 days a week). 0121 433 8702 or [email protected]

Not registered for an account with BioCare®?

You can register now to receive up to date news, product information and exclusive offers whether you are a consumer, practitioner or retailer.

References

[1] Sawler J et al. The genetic structure of marijuana and hemp. PLoS One. 2015; 10 (8): e0133292.

[2] Lu H-C, Mackie K. An introduction to the endogenous cannabinoid system. Biol Psychiatry. 2016; 79 (7): 516-525.

[3] Kendall DA, Yudowski GA. Cannabinoid receptors in the central nervous system: their signaling and roles in disease. Front Cell Neurosci. 2016; 10: 294.

[4] Pertwee RG. The pharmacology of cannabinoid receptors and their ligands: an overview. Int J Obes (Lond). 2006; 30 Suppl 1: S13-8.

[5] Zuardi AW. Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. Braz J Psychiatry. 2008; 30 (3): 271-80.

[6] Crippa JA et al. Translational investigation of the therapeutic potential of cannabidiol (CBD): toward a new age. Front Immunol. 2018; 9: 2009.

[7] Khan R et al. The therapeutic role of cannabidiol in mental health: a systematic review. J Cannabis Research. 2020; 2:2

[8] Maroon J, Bost J. Review of the neurological benefits of phytocannabinoids. Surg Neurol Int. 2018; 9: 91.

[9] Zanelati TV et al. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Br J Pharmacol. 2010; 159 (1): 122-8.

[10] Zuardi AW et al. Inverted U-shaped dose-response curve of the anxiolytic effect of cannabidiol during public speaking in real life. Front Pharmacol. 2017; 8: 259.

[11] Crippa J et al. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacology. 2011; 25 (1): 121-30.

[12] Bergamaschi MM et al. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology. 2011; 36 (6): 1219-26.

[13] Shannon A et al. Cannabidiol in anxiety and sleep: a large case series. Perm J. 2019; 23: 18-041.

[14] Davies C, Bhattacharyya S. Cannabidiol as a potential treatment for psychosis. Ther Adv Psychopharmacol. 2019; 9.

[15] Leweke FM et al. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizoprenia. Transl Psychiatry. 2012; 2 (3): e94.

[16] Bhattacharyya S et al. Effect of cannabidiol on medial temporal, midbrain, and striatal dysfunction in people at clinical high risk of psychosis: a randomised clinical trial. JAMA Psychiatry. 2018; 75 (11): 1107-1117.

[17] De Faria SM. Effects of acute cannabidiol administration on anxiety and tremors induced by a simulated public speaking test in patients with Parkinson’s disease. J Psychopharmacol. 2020; 34 (2): 189-196.

[18] Branca JJ et al. Cannabidiol protects dopaminergic neuronal cells from cadmium. Int J Environ Res Public Health. 2019; 16 (22): 4420.

[19] Rudroff T, Sosnoff J. Cannabidiol to improve mobility in people with multiple sclerosis. Front Neurol. 2018; 9: 183.

[20] Mecha M et al. Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress. Cell Death Dis. 2012; 3 (6): e331.

[21] Cassano T et al. From Cannabis sativa to cannabidiol: promising therapeutic candidate for the treatment of neurodegenerative diseases. Front Pharmacol. 2020; 11: 124.

[22] Booz GW. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med. 2011; 51 (5): 1054-1061.

[23] Stanley CP et al. Is the cardiovascular system a therapeutic target for cannabidiol? Br J Clin Pharmacol. 2013; 75 (2): 313-22.

[24] Vos T et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017; 390 :1211–1259.

[25] Capano A et al. Evaluation of the effects of CBD hemp extract on opiod use and quality of life indicators in chronic pain patients: a prospective cohort study. Postgrad Med. 2020; 132 (1): 56-61.

[26] De Petrocellis L et al. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Br J Pharmacol. 2011; 163 (7): 1479-1494.

[27] World Health Organisation. CANNABIDIOL (CBD) Pre-Review Report. 2017. Available at:https://www.who.int/medicines/access/controlled-su.

[28] Ujváry I, Hanuš L. Human metabolites of Cannabidiol: a review on their formation, biological activity, and relevance in therapy. Cannabis Cannabinoid Res. 2016; 1 (1): 90-101.

[29] Knaub K et al. A novel self-emulsifying drug delivery system (SEDDS) based on VESIsorb ® formulation technology improving the oral bioavailability of cannabidiol in healthy subjects. Molecules. 2019; 24 (16): E2967.

Are you seeing CBD products everywhere at the moment but feel unsure of what it actually is, what it means and how it could help you? Find out more here.

CBD BioCare Company Review

With the increase in popularity of CBD products that claim to improve your health and relieve pain and other common issues, it can be hard to figure out which brand to buy from. However, not every company sells equally effective and pure products, so it’s important to read in-depth reviews of CBD companies to understand which ones you might want to trust.

Let’s take a deeper look at CBD BioCare, a company that has a long-standing reputation for providing quality products.

CBD BioCare Company Overview

CBD BioCare has been on the market for a number of years and has thousands of happy customers. Something that makes CBD BioCare unique is that it goes beyond the average brand in sharing a lot of useful resources about the benefits and usage of CBD products. It talks about why you might want to use CBD oils and tinctures, but also when you might want to avoid these products and choose something else.

The company also shares a complete overview of how its products are made, so you can better understand the item you’re thinking of buying.

CBD BioCare Laboratory Tests and Certificates

Companies can claim many things about their CBD products, but it’s always important to consider whether the reported cannabinoid profile on the label could be inaccurate. In addition, some CBD products on the market contain heavy metals and other potentially harmful chemicals.

That’s why it’s critical for companies to test these products through a laboratory outside of their own control. This third-party testing is a great way for a brand to show that its products are as good as it claims they are, and for customers to see that the items are safe and accurately described.

CBD BioCare’s website includes a page with the latest certificates of analysis for its products. They list any safety concerns, as well as the specific compounds found inside each product. Each product you purchase contains a QR code, and scanning this code takes you directly to the lab-testing certificates page.

CBD BioCare Product Range

CBD BioCare has a variety of products available that target specific issues, including:

  • CBD BioCare original, including CBD tinctures and drops
  • CBD BioSkincare, a range of creams and serums that help to improve skin health
  • CBD BioPetcare, a variety of products specifically designed for your pets

CBD BioCare Product Pricing

One thing we did note is that the CBD BioCare prices tend to be a little higher compared to some of the brand’s competitors. For example, the Full Spectrum CBD Liquid Capsules can be picked up for $24.99, but this is for the weakest formulation available. The Full Spectrum CBD Oil starts at $64.99.

CBD BioCare Shipping Policies

Both domestic and international shipping options are available from CBD BioCare. Shipping to an address in the United States is free if your order includes at least two products. A standard shipping rate of $5.99 is applied to other domestic orders.

International shipping will incur a minimum charge of $13.30.

CBD BioCare Return Policy

While CBD BioCare offers a satisfaction guarantee, note that you’ll need to return any unused products within 14 days of the purchase date. If you return a product that you tried, but that didn’t work for you, you’ll be refunded based on the unused portion that you return to the company.

Customer Reviews and Opinions

We always read customer reviews on third-party websites to determine if a particular CBD company is trustworthy and whether its products are effective.

CBD BioCare shares reviews on its website that it imports from external sources, including Facebook and Google. This helps ensure that reviews are unbiased.

The average rating is 4.9 out of 5.0, which is very impressive. To give you a better idea of the customer experience, let’s read a couple of reviews:

“I absolutely love CBD BioCare products. The CBD oil works to keep anxiety, and PTSD triggers less intense and more manageable. The pain cream totally works, as well. It relieves muscle pain quite well.”

“Legit product. The oil is great for my anxiety as well as helping me sleep. They have phenomenal customer service, as well.”

“Love the products I have purchased. I feel they worked well, but if there was any negative to the products, it would be the price.”

Overall, the reviews tell us that people find that CBD BioCare products to be effective, but that the prices are high compared to other companies.

Final Verdict

CBD BioCare is a trusted company that offers a variety of products that customers rely on. This brand manufactures high-quality CBD tinctures as well as a range of other products, including anti-aging creams and more. Customer reviews seem to be mostly positive. CBD BioCare offers a complete list of lab-testing certificates to give you peace of mind that the products are safe and pure. It’s not the most affordable CBD company, but it seems to overall be a good option.

Shopping for CBD products? Check out our detailed CBD BioCare review to learn more about its pricing, shipping, return policy, and more.