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Some CBD products may yield cannabis-positive urine drug tests

In a study of six adults, Johns Hopkins Medicine researchers report evidence that a single vaping episode of cannabis that is similar in chemical composition to that found in legal hemp products could possibly result in positive results on urine drug screening tests commonly used by many employers and criminal justice or school systems.

The U.S. government defines hemp as any crop of cannabis containing 0.3% THC or less in dry weight. THC (delta-9-tetrahydrocannabinol) is the substance in cannabis that confers a “high” and produces the subjective and cognitive effects that are typically synonymous with cannabis. The 2018 U.S. Farm Bill legalized the production and sale of hemp, and now as a result, consumer hemp products, such as oils, vaping cartridges and hemp flowers for smoking can be legally purchased in specialty stores, general retail stores and through websites across the U.S.

Hemp is now increasingly finding use in medicine and wellness markets, particularly for its component CBD, short for cannabidiol, which is one of the more than 100 cannabinoids found in the cannabis plant. According to New York-based investment bank Cowen & Co., the market for CBD last year ranged from $600 million and $2 billion in sales. Despite the size of this booming industry, it remains largely unregulated.

In a paper published Nov. 4 in the Journal of Analytical Toxicology, the researchers report that two out of six study participants tested positive after vaping cannabis that contained 0.39% THC using urine testing methods that are consistent with testing frequently performed for employment-related or criminal justice-related urine drug testing programs. Though the cannabis used in this study does not currently meet the federal definition of hemp, the THC concentration of 0.39% exceeds federal regulation by just 0.09%.

“People who use legal hemp products for medical intent rarely just use them once as we did in this study, and prior studies show that THC and its metabolites may accumulate with repeated use,” says postdoctoral fellow Tory Spindle, Ph.D., a researcher in the Behavioral Pharmacology Research Unit at the Johns Hopkins Bayview Medical Center. “What this means is that people need to be wary of single-dose or cumulative THC exposure and be aware that these now legal products may cause an unexpected positive result on a drug test.”

“Because the market for CBD products is so new and the popularity of use is growing so quickly, we want the public to be aware that a positive drug test is possible,” says Ryan Vandrey, Ph.D., associate professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. Vandrey and his collaborators at the University of Pennsylvania previously showed in a JAMA study that 21% of CBD/hemp products sold on the Internet contained THC, even though it wasn’t listed on the product labels. “I have a hard time finding anyone who hasn’t used a CBD product at least once, but most are completely unaware of the possibility of THC exposure or a positive drug test as a result of using these newly legalized products,” says Vandrey.

trials demonstrated CBD to be an effective treatment for two rare forms of pediatric epilepsy, however, there is currently insufficient evidence to support use for any other health condition according to the U.S. Food and Drug Administration. Despite this, CBD product suppliers and consumers claim benefits of CBD for a wide range of purposes, including everything from anxiety to insomnia to general wellness. CBD products can be swallowed in the form of an oil/tincture, eaten in a food product (e.g., gummy bears), inhaled using “vape pens” similar to electronic cigarettes, or applied topically to the skin in a cream, patch, balm or gel.

For the current study, the researchers recruited three women and three men with an average age of 31 years old. One participant self-reported as African American and the rest as white.

The batch of cannabis used in this particular study contained 10.5% CBD and 0.39% THC, a 27 to 1 ratio of CBD to THC that is similar to what is often found in legal hemp/CBD products. In the study, research volunteers vaporized a little less than 1 gram of cannabis, which contained a total dose of 100 milligrams of CBD and 3.7 milligrams of THC. To vape the cannabis, heated cannabis vapor was collected into a balloon that was then inhaled by the participant.

In addition to vaping the high CBD/low THC cannabis, study volunteers also were given pure CBD in a capsule, vaporized pure CBD and placebo (a mock CBD pill and vaporized cannabis in which CBD and THC had been removed) in three other dosing sessions, one week apart from each other. In all active drug conditions (excluding placebo), the CBD dose delivered was 100 milligrams per session.

The drug testing cut-off used to determine a “positive” result in this study was a “screening” concentration of at least 50 nanograms per milliliter of THCCOOH, a metabolite used to indicate whether someone has used cannabis, in the urine sample using an on-site “dipstick” test. A positive on that test was then “confirmed” at a 15 nanograms per milliliter cut-off of THCCOOH using a more sensitive test method.

Two of the six participants who vaped the low-THC/high-CBD cannabis tested positive for THCCOOH.

No positive urine drug test results were observed in the other test sessions (pure CBD capsules, pure CBD vape or placebo).

“These results suggest that pure CBD, used once by itself, will not cause a positive drug test,” says Vandrey. Adding to this, Spindle points out that it “does not take much THC exposure to trigger a positive test for some people.” There may be variation from person to person in drug metabolism and puffing behaviors such as inhalation depth, which might contribute to the breakdown or buildup of cannabinoids in the body, the researchers say.

The team says they plan to repeat their studies using products that fall within the current federal hemp regulations with respect to THC content, and additionally study the impact of repeated CBD/hemp exposure on drug testing outcomes.

Other authors on the study were Edward Cone and George Bigelow of Johns Hopkins, David Kuntz of Clinical Reference Laboratory, John Mitchell of RTI International and Ronald Flegel of the Substance Abuse and Mental Health Services Administration (SAMHSA).

This research was supported by SAMHSA and the National Institute on Drug Abuse (T32DA07209).

COI: Vandrey has been a paid consultant for or received honoraria from Zynerba Pharmaceuticals, FSD Pharma and Canopy Health Innovations Inc.

Hemp is now increasingly finding use in medicine and wellness markets, particularly for its component CBD, short for cannabidiol, which is one of the more than 100 cannabinoids found in the cannabis plant. According to New York-based investment bank Cowen & Co., the market for CBD last year ranged from $600 million and $2 billion in sales. Despite the size of this booming industry, it remains largely unregulated.

In a paper published Nov. 4 in the Journal of Analytical Toxicology, the researchers report that two out of six study participants tested positive after vaping cannabis that contained 0.39% THC using urine testing methods that are consistent with testing frequently performed for employment-related or criminal justice-related urine drug testing programs. Though the cannabis used in this study does not currently meet the federal definition of hemp, the THC concentration of 0.39% exceeds federal regulation by just 0.09%.

“People who use legal hemp products for medical intent rarely just use them once as we did in this study, and prior studies show that THC and its metabolites may accumulate with repeated use,” says postdoctoral fellow Tory Spindle, Ph.D., a researcher in the Behavioral Pharmacology Research Unit at the Johns Hopkins Bayview Medical Center. “What this means is that people need to be wary of single-dose or cumulative THC exposure and be aware that these now legal products may cause an unexpected positive result on a drug test.”

“Because the market for CBD products is so new and the popularity of use is growing so quickly, we want the public to be aware that a positive drug test is possible,” says Ryan Vandrey, Ph.D., associate professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. Vandrey and his collaborators at the University of Pennsylvania previously showed in a JAMA study that 21% of CBD/hemp products sold on the Internet contained THC, even though it wasn’t listed on the product labels. “I have a hard time finding anyone who hasn’t used a CBD product at least once, but most are completely unaware of the possibility of THC exposure or a positive drug test as a result of using these newly legalized products,” says Vandrey.

Trials demonstrated CBD to be an effective treatment for two rare forms of pediatric epilepsy, however, there is currently insufficient evidence to support use for any other health condition according to the U.S. Food and Drug Administration. Despite this, CBD product suppliers and consumers claim benefits of CBD for a wide range of purposes, including everything from anxiety to insomnia to general wellness. CBD products can be swallowed in the form of an oil/tincture, eaten in a food product (e.g., gummy bears), inhaled using “vape pens” similar to electronic cigarettes, or applied topically to the skin in a cream, patch, balm or gel.

For the current study, the researchers recruited three women and three men with an average age of 31 years old. One participant self-reported as African American and the rest as white.

The batch of cannabis used in this particular study contained 10.5% CBD and 0.39% THC, a 27 to 1 ratio of CBD to THC that is similar to what is often found in legal hemp/CBD products. In the study, research volunteers vaporized a little less than 1 gram of cannabis, which contained a total dose of 100 milligrams of CBD and 3.7 milligrams of THC. To vape the cannabis, heated cannabis vapor was collected into a balloon that was then inhaled by the participant.

In addition to vaping the high CBD/low THC cannabis, study volunteers also were given pure CBD in a capsule, vaporized pure CBD and placebo (a mock CBD pill and vaporized cannabis in which CBD and THC had been removed) in three other dosing sessions, one week apart from each other. In all active drug conditions (excluding placebo), the CBD dose delivered was 100 milligrams per session.

The drug testing cut-off used to determine a “positive” result in this study was a “screening” concentration of at least 50 nanograms per milliliter of THCCOOH, a metabolite used to indicate whether someone has used cannabis, in the urine sample using an on-site “dipstick” test. A positive on that test was then “confirmed” at a 15 nanograms per milliliter cut-off of THCCOOH using a more sensitive test method.

Two of the six participants who vaped the low-THC/high-CBD cannabis tested positive for THCCOOH.

No positive urine drug test results were observed in the other test sessions (pure CBD capsules, pure CBD vape or placebo).

“These results suggest that pure CBD, used once by itself, will not cause a positive drug test,” says Vandrey. Adding to this, Spindle points out that it “does not take much THC exposure to trigger a positive test for some people.” There may be variation from person to person in drug metabolism and puffing behaviors such as inhalation depth, which might contribute to the breakdown or buildup of cannabinoids in the body, the researchers say.

The team says they plan to repeat their studies using products that fall within the current federal hemp regulations with respect to THC content, and additionally study the impact of repeated CBD/hemp exposure on drug testing outcomes.

Other authors on the study were Edward Cone and George Bigelow of Johns Hopkins, David Kuntz of Clinical Reference Laboratory, John Mitchell of RTI International and Ronald Flegel of the Substance Abuse and Mental Health Services Administration (SAMHSA).

This research was supported by SAMHSA and the National Institute on Drug Abuse (T32DA07209).

A small study concludes that caution is warranted for users of ‘high CBD, low THC’ cannabis products.

Can Hemp Oil Make You Fail Drug Test?

Like it or not, many job applicants are required to take drug tests. It is mandatory for government employees but some private companies as well. Below we discuss whether hemp oil can make you fail a drug test.

Hemp oil has been dubbed the super supplement because it’s rich in essential fatty acids, minerals, and vitamin E. Plus, this oil is known to help with a variety of conditions, including cardiovascular disease, skin disorders, and menopause symptoms.

In general, there is almost no risk of failing a drug test from using hemp oil. Most of these oils don’t contain any cannabinoids (CBD, which means no THC), so you don’t need to worry about the drug test. Still, it would make sense to know more about the oil to be absolutely sure.

What is Hemp Oil?

Hemp oil, also known as hemp seed oil, comes from industrial hemp, a strain of Cannabis sativa. The plant itself contains very low levels of THC and relatively high levels of CBD. But hemp oil is obtained from industrial hemp seeds which contain even lower amounts of all cannabinoids.

The producers use the cold press method to extract the oil from hemp seeds. The process involves removing the outer husk and de-shelling, before chilling and squeezing what’s remained to get the extract. The dark green oil is not refined and features a full profile of bioactive compounds and nutrients.

More importantly, the final product doesn’t contain any cannabinoids and is not psychoactive. This you can be sure of as the manufacturers want to sell the oil in all 50 states. It’s like get a G rating for a moving versus NC-17. You are certain to make more sales.

Hemp Oil vs. CBD Oil

Both types of oil are derived from industrial hemp, but they shouldn’t be confused. Unlike hemp oil, CBD oil is extracted from the stalk, leaves, and flowers of the plant. It contains cannabinoids and might cause you to fail a drug test – this would depend on the level of THC, the psychoactive cannabinoid.

In fact, CBD oil is behind the wave of marijuana legalization in the US. The various CBD compounds have medicinal purposes but not THC, which is only for getting high. Many opponents of marijuana legalization have accused the proponents for using the medicinal properties of CBDs to push marijuana through, when you really don’t use marijuana to treat diseases – you only need CBD oil.

CBD oil a potent antioxidant, pain reliever, and anti-inflammatory agent.

But, can hemp oil make you fail drug tests?

Hemp oil and Drug Tests

The common urine screening utilizes an immunoassay with antibodies that confirm the presence of THC and other banned substances.

The test looks for 11-nor-delta9-carboxy-THC (THC-COOH), which is one of the main THC metabolites. The threshold amount is 50ng/mL of THC, over which the test will show positive. To make sure that it’s not a false positive, the lab will use a gas chromography/mass spectrometry (GC/MS) test to confirm the results.

Professionally done drug test samples are always split into A and B samples. If you test positive, you can request the lab to test your B sample. If the lab happens to lose your B sample, they will not be able to confirm the positive. By rule, they will have to give you a passing grade.

Important Notes

In theory, people who consume between 1,000 and 2,000mg of hemp oil every day might fail the first urine tests. These are very rare cases and they indicate a false positive if certain non-THC metabolites trigger the immunoassay reaction. However, the following GC/MS test is going to be negative.

When all is said and done, you need to source high-quality hemp oil and stick to the recommended intake. This way it is highly unlikely to fail a drug test.

Correct Dosage

Hemp oil can be used orally or topically. For topical use, apply a generous amount of oil directly onto the affected area a few times a day.

When it comes to oral use, one or two tablespoons a day are enough to help inflammations, digestion, and heart health. The dosage may vary depending on your age, weight, and exact medical condition.

fail a drug test from hemp oil?

The bottom line is that there is no risk of failing a drug test as long as the hemp oil doesn’t contain any THC or CBD. Even if there are some cannabinoids in the oil, the concentration is far below the amount required for you to test positive.

The important thing is to find a reliable full-spectrum hemp oil and follow the recommended dose. And if you are not sure about the application or dosage, consult your physician.

In general, there is almost no risk of failing a drug test from using hemp oil. Most of these oils don’t contain any cannabinoids