cannabis oil multiple myeloma

Cannabis oil?

Cancer Chat Homepage

  • Welcome to the forum
    • Introduce yourself
    • Help using our forum
    • Community guidelines
    • Meet the team
    • About Us
    • Contact a moderator
  • Talk about cancer
    • Waiting for a diagnosis
    • Newly diagnosed
    • Living with cancer
    • Caring for someone with cancer
    • Diagnosed with cancer at a young age
    • Ask the nurses
    • Dying with cancer
    • Coping with loss
    • Hot cancer topics
  • Daily living
    • Money, Work & Travel
    • Healthy living
    • Life after cancer
  • Get involved
    • Take part in studies & research
    • Your fundraising
    • How you can help Cancer Research UK
  • General chat
    • Inspiration
    • Off topic
    • Laughter is the best medicine
    • Noticeboard

Coronavirus and cancer

We know it’s a worrying time for people with cancer, we have information to help. If you have symptoms of cancer contact your doctor.

Register to post

Sign in to post

Cannabis oil?

Hi again. My dad is currently using manuka honey. I have also read about cannabis oil. Has anyone tried this and if so, would they recommend and where can you purchase it from? Many thanks

Cannabis oil?

Hi thanks for your reply. No I didn’t realise this. Thanks for your advice.

2762 posts since

Cannabis oil?

This question comes up a lot – both Manuka honey and Cannabis oil are pretty controversial, with sceptics saying they are quack remedies and supporters claiming they are miracle cures. Apparently New Zealand (the only place where the Manuka flowers apart from a small number of farms in Australiia) only produces 1,700 tons of Manuka honey a year but globally 10,000 tons are sold, so the chances of buying the genuine unadulterated product are slim. This article looks interesting

This recent Huffington Post article about Cannabis oil as a cancer cure is pretty well balanced and gives both sides of that argument

I beieve cannabis oil is currently illegal in the UK, but the situation is both complex and evolving and there are some exceptions see

362 posts since

Cannabis oil?

When first diagnosed with multiple myeloma, two of my sons, one a staunch supporter of medicinal cannabis oil, went out and got me cannabis oil from two different sources.

I didn’t take it for the following reasons.

Note firstly that I have no moral reservations about it.

Being illegal in the UK, the sources must also be illegal. Importantly, this means there is no quality control on the ingredients or any hygeine standards adhered to and the people selling it are in it purely for the money.

Secondly but most important, is the fact that, as I was on chemo at the time, if any progress or regress happened, it would be impossible to tell what was having an effect, the chemo or the cannabis or a combination. This I felt would detract from the medical practitioners’ options.

If I were in the end stages of life my response might be different as the anecdotal evidence for pain relief, or at least not caring, is fairly substantial.

Cannabis oil?

Many thanks Taff for your reply, food for thought. Kind regards

Cannabis oil?

Thanks for your reply Dave. I will have a read of the articles within your reply.

Cannabis oil?

CBD oil is legal in the UK, the oil that contains THC is illegal. I got CBD oil for my stepdad with pancreatic cancer. He used it for a few weeks while trying to put weight on for chemo but stopped for unknown reasons, I think the cancer scared him so much he wanted to do exactly as the doctors recommended despite only having months left. Frustrating for me as the bottles are not cheap for the best quality and I have 2 unopened black label left in the cupboard.

Cannabis oil?

Many thanks for your reply Jones0343. Kind regards

Cannabis oil?

Hello, I have just joined to let you know that yes you can buy CBD(Hemp) oil in the U.K. Holland and Barrett have it, 10ml for usually £19.99. I buy it for my teen son’s depression, he swears by it. Thanks x

347 posts since

Cannabis oil?

It feels like there’s a bit of confusion surrounding exactly what is and isn’t legal, so Ive asked the team here to help clear things up. They’ve written a response which is really helpful in getting to the bottom of all this, and explaining the difference between cannabis oil and hemp (or CBD) oil. I hope it’s of interest!:

Cannabis oil is not legal in the UK. This is because it contains the mind-altering substance THC. Jones0343 correctly says that hemp (or CBD) oil is legal in the UK – this is because it has extremely low levels of THC in it so doesn’t have any mind-altering effects.

Scientists have been working to understand the potential benefits of using molecules found in cannabis (cannabinoids) to treat cancer for a while. We’ve written about the evidence for using cannabinoids to treat cancer extensively in this blog post.

There’s little in the way of evidence to suggest that either cannabis or hemp oil benefits most cancer patients. An early-stage trial we supported testing a drug called Sativex (made from cannabis extract) combined with temozolomide showed that it helped patients with brain tumours that had come back live longer. We’ll need to wait for further, larger trials to be certain of its benefits, and we don’t know if it will help people with other types of cancer.

Although there’s emerging evidence that molecules found in cannabis may one day be used to help people with cancer, we would advise against using black market or home-made preparations of cannabis oil. Not only is it illegal, but because it’s unregulated these products might be contaminated with harmful substances and vary in strength. Taking cannabis could also potentially interfere with other cancer treatments given to you by a doctor, and can carry other side effects and risks.

Cannabis oil? Cancer Chat Homepage Welcome to the forum Introduce yourself Help using our forum Community guidelines Meet the team About Us Contact a

Multiple Myeloma Chemotherapy- C-B-D Enhances Velcade (BORT)

These results showed that Cannabidiol (C-B-D) by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death…

Newly diagnosed myeloma patients are often told that their cancer is incurable but very treatable.” When I was first diagnosed with MM in early ’94, I didn’t understand what that meant for me as a newly diagnosed MM patient. I didn’t know that both C-B-D and chemotherapy both would be important.

Conventional MM oncology talks only about FDA approved therapies- multiple myeloma chemotherapy, surgery and radiation. When your oncologist tells you that your MM is incurable but very treatable, he/she means that there is a long and growing list of FDA approved MM chemotherapy regimens.

What is equally important for newly diagnosed MM patients to understand is that there is also a long and growing list of evidence-based, non-conventional MM therapies as well. Research has shown that these therapies are cytotoxic (kill) MM and well as can enhance MM chemotherapy to kill MM more effectively.

Unfortunately, while C-B-D oil, according to the study linked below, treats MM, your oncologist will not talk about it. Conventional oncology generally sticks with talking about only conventional, FDA approved therapies.

What have I learned about MM since my diagnosis in 2/94?

Myeloma is about two things

  1. symptoms (bone damage, anemia, kidney damage, etc.) and
  2. side effects from toxic chemotherapy (bone damage, anemia, kidney damage, etc.)

MMers usually don’t die from their cancer. They die from health problems caused by their cancer such as bone damage, anemia, kidney damage and/or from the toxicity caused by chemotherapy and radiation.

The solution? Take an integrative approach to managing your multiple myeloma. Enhance the efficacy of chemotherapy and while you reduce the toxicity.

Based on the study linked below, cannabidiol/cannabis can work both on its own and with Velcade (Bortezomib) to induce cell death in Multiple Myeloma cells.

Conventional therapies can help you manage your MM. Non-conventional therapies can help you manage your MM. In my experience and research, MM patients and survivors will need every therapy tool in the MM tool box.

If you or a loved one has been diagnosed with Multiple Myeloma, let me say this loud and clear:

It is critical that you become an active participant in your care. Learn everything you can.

I am alive today largely because I took the time to find out everything I could about Multiple Myeloma and sought out the full spectrum of evidence-based MM therapies both conventional (FDA approved) and non-conventional.

Your decision-making begins by learning about the full spectrum of evidence-based myeloma therapies, both conventional and non-conventional. Here are some questions you may have right now:

  • Do Multiple Myeloma specialists know more about MM than regular oncologists? Yes.
  • What side effects should I expect from my induction chemotherapy? Prevention is key.
  • What do I do if I don’t reach complete remission? Don’t panic.
  • What therapies can I use that my oncologist won’t tell me about? Triplets are superior to doublets.
  • Does it matter if I wait to have an autologous stem cell transplant? No. Studies show there is no survival advantage either earlier or later.

To learn more about the topics covered in the Multiple Myeloma Coaching Program, click here for a complete lesson outline.

The PubMed study linked and excepted below cites the ability cannabidiol to kill mm cells and increase the efficacy of Velcade (bortezomib).

I wish you all the best on your Multiple Myeloma journey.

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

  • Conventional, Integrative and Alternative-Multiple Myeloma Cancer Coaching-
  • Survival Rates for Multiple Myeloma
  • Multiple Myeloma Chemotherapy- Evidence-Based, Non-Conventional

The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2.

“Multiple myeloma (MM) is a plasma cell (PC) malignancy characterised by the accumulation of a monoclonal PC population in the bone marrow (BM).

Cannabidiol (CBD) is a non-psychoactive cannabinoid with antitumoural activities, and the transient receptor potential vanilloid type-2 (TRPV2) channel has been reported as a potential CBD receptor.

TRPV2 activation by CBD decreases proliferation and increases susceptibility to drug-induced cell death in human cancer cells.

However, no functional role has been ascribed to CBD and TRPV2 in MM. In this study, we identified the presence of heterogeneous CD138+TRPV2+ and CD138+TRPV2- PC populations in MM patients, whereas only the CD138+ TRPV2- population was present in RPMI8226 and U266 MM cell lines.

Because bortezomib (BORT) is commonly used in MM treatment, we investigated the effects of CBD and BORT in CD138+TRPV2- MM cells and in MM cell lines transfected with TRPV2 (CD138+TRPV2+).

These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells. These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in MM.”

Cannabinoids used in sequence with chemotherapy are a more effective treatment for cancer, say experts

“Cannabinoids -the active chemicals in cannabis – are effective in killing leukemia cells, particularly when used in combination with chemotherapy treatments, new research confirms…

Researchers also found that sequential use of an initial dose of chemotherapy first and then cannabinoids significantly improved overall results against the blood cancer cells. They found that combining existing chemotherapy treatments with cannabinoids had better results than chemotherapy alone, meaning that a similar level of effect could be achieved through using a lower dose of the chemotherapy.

If this were translated to humans, this lower dose of chemotherapy would mean that the side-effects of chemotherapy could be lessened…

“We have shown for the first time that the order in which cannabinoids and chemotherapy are used is crucial in determining the overall effectiveness of this treatment…

“These extracts are highly concentrated and purified, so smoking marijuana will not have a similar effect. But cannabinoids are a very exciting prospect in oncology, and studies such as ours serve to establish the best ways that they should be used to maximise a therapeutic effect.”

Multiple Myeloma Therapy- Medical Marijuana? CBD?

Studies Document the Ability of Medical Marijuana to Manage Cancer Pain, Enhance the Efficacy of Conventional MM Chemotherapy and Kill Myeloma cells-

If you’ve been diagnosed with multiple myeloma (MM), you may be overwhelmed with emotion and confusion. The first thing all newly diagnosed MM patients must wrap their brain around is that MM is considered to be incurable by conventional oncology. It is in your best interest to include evidence-based conventional and non-conventional multiple myeloma therapy. Medical marijuana, CBD oil is one such MM therapy.

The mission of PeopleBeatingCancer is to provide you with information about both conventional and evidence-based non-conventional MM therapies. Medical marijuana is one such evidence-based non-conventional MM therapy.

The devil is in the details as they say.

Cannabis is controversial and must be tested and researched. The first link below will take you to an excellent slide show on the topic. The second link will take you to the PeopleBeatingCancer posts on MM.

Recreational marijuana is of no interest to me. I tried it as a teen and became sleepy and anti-social. Back in those days I wanted to be social and awake.

Skip ahead 40 years. I am a long-term multiple myeloma survivor and MM cancer coach. One of the most common questions I’m asked on PeopleBeatingCancer is if multiple myeloma patients will benefit from medical marijuana or CBD oil- “is CBD good for MM?”

I can make arguments both pro and con for the legalization of recreational marijuana but not for the legalization of medical marijuana.

The benefit of medical cannabis is a pure benefit to society. Regulate it, tax it but make it available for MM patients and survivors.

Cannabinoids as medical therapy is still relatively new. The five issues listed below must be addressed before cancer patients, survivors and caregivers can safely use medical marijuana.

  • Dosing,
  • Efficacy,
  • Strain
  • Cannabinoid/THC Ratio
  • Source

For more information on cancer and medical use of cannabis, scroll down the page, post a question or comment and I will reply ASAP.

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

  • Mind-Body Therapy for the Multiple Myeloma Survivor
  • Late Stage Chemobrain for Multiple Myeloma?
  • Vaccination Post Stem Cell Transplant? Yes or no?

What Is Medical Marijuana?

Medical marijuana is any part of the marijuana plant that you use to treat health problems. People use it to get relief from their symptoms, not to try to get high.

Most marijuana that’s sold legally as medicine has the same ingredients as the kind that people use for pleasure. But some medical marijuana is specially grown to have less of the chemicals that cause feelings of euphoria.

10 blog posts from PeopleBeatingCancer about medical marijuana, cannabis, or cannabidiol-

The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2.

” These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells. These data provide a rationale for using CBD to increase the activity of proteasome inhibitors in MM.”

Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration

“Herein, we also found that the CBD and THC combination is able to reduce expression of the β5i subunit as well as to act in synergy with CFZ to increase MM cell death and inhibits cell migration. In summary, these results proved that this combination exerts strong anti-myeloma activities…”

These results showed that Cannabidiol by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cell… ]]>