Can You Be Allergic to CBD?
Great question and the vast majority of CBD brands might be making the problem worse.
By vast majority, we’re estimating in the 90 percentile!
We’ll explain later.
Of course, mast cells figure right into this nonsense.
We’ll get into it below.
Most importantly, we’ll touch base on why so many people may have allergic responses when taking “CBD”.
The parentheses are not just there for looks or emphasis.
The type of “CBD” has a huge bearing on the potential for allergic reactions.
Let’s get into it.
Here are the topics:
- Quick intro to the allergic reaction process
- Can a person be allergic to CBD
- Allergies to Full Spectrum CBD
- Allergic to hemp oil
- Allergic to CBD isolate
- Can you get allergic hives from CBD
- Can dogs be allergic to CBD
Quick intro to the allergic reaction process
To really see how allergies may or may not be caused by CBD, we need background.
The allergic response is actually part of our immune system.
It primarily resides in the mast cells!
Mast cells are special cells throughout the body that are designed to look for foreign entities as a sign of attack.
They’re guards so to speak on the lookout for bacteria, viruses, and other intruders.
Their role is to get that stuff out of the body any which way they can.
Watery eyes. Sneezing. Coughing. Hives. Swelling. Etc.
We know all too well what the “symptoms” are but this is just the M.O. of mast cells.
It’s the primary trick they know!
We can appreciate it with a bee sting but really. pet dander??
One of the key weapons Mast Cells has is histamine.
Histamine is a hormone released from these cells when triggered.
It’s the key root of all these allergic reactions in the body.
Interestingly, histamine is excitatory in the brain there’s a whole discussion on CBD for histamine and anxiety here.
So that’s the 101 on our body’s allergic reaction.
Now. to the question at hand…
Can you have an allergic reaction to CBD?
Can a person be allergic to CBD
First, we need to really define “CBD oil”.
We want to focus on just CBD isolate itself.
This is where it gets confusing since CBD oil is not regulated.
People are usually taking in lots of other stuff with their “CBD oil”.
Let’s talk about allergies based on three main ways people take CBD:
- Full-spectrum CBD oil
- Hemp oil
- CBD isolate
These three options will have a very different allergy and histamine profiles.
Let’s look at each.
Full Spectrum CBD and allergic response
Basically, with full-spectrum, you have a lot more of the hemp plant material in the oil.
This gives plenty more ways to have an allergic reaction.
Full Spectrum CBD is allowed to have up to .3% THC which is a known allergen.
Here’s the deal. if you have other allergies, there’s a good chance you’ll have a reaction to cannabis in its raw form.
A study showed that 70% of the 50 million Americans with allergies will have a reaction to cannabis.
It’s not just the THC.
It’s a plant after all and plant material is a known issue for people with allergies.
It turns out that there are proteins in the plant that set off the allergic reaction to cannabis.
One note. CBD oil is derived from hemp which is just another name for cannabis with less than .3% THC.
Full-spectrum CBD is basically extracted CBD added back into hemp oil.
It’s a way to jack up the CBD volume above what naturally occurs in the plant to get a baseline amount.
It’s the hemp oil that’s the issue!
Speaking of which….
Hemp oil and allergic reaction
If full-spectrum is hemp oil with CBD added to increase volume of CBD amounts, hemp oil is just the oil.
It’s amazing for us.
Millions of Americans are using hemp oil and a good percentage of them are probably allergic to it.
They’re buying hemp oil to feel better after all!
Almost all the research is on CBD and THC.
Just google “hemp oil NIH” and it will all be CBD (and maybe THC).
CBD is very different, even directly opposite to THC.
THC has some known issues (new report on how it affects Sperm gene pathways just today!).
The research on CBD has been remarkably positive.
Research on “hemp oil”??
There may be lots of good stuff in there but not if you’re prone to allergies.
This is especially true for:
- Women (allergies and histamine issues have a significant gender effect)
- Adults over 40 (falling hormones affect allergic sensitivities)
- People allergic to other substances
It’s all one system in terms of how we respond to allergies.
Hemp oil has all the same allergy-provoking proteins we mentioned in full-spectrum CBD.
So. what about CBD by itself? Isolate?
Allergic response to CBD Isolate
CBD isolate usually refers to CBD the chemical, being added to a base oil.
The common base oils are:
- MCT oil (extract from coconut oil)
- Hemp oil
- Olive oil
You can also get just CBD as a crystal (it’s raw form) but this is not as popular since it’s more difficult to deal with.
Obviously, the hemp and olive oil may pose the same issues we discussed above with just hemp oil.
MCT oil is an extract from coconut oil.
It’s basically medium-chain fats from coconut oil.
CBD is best absorbed in the presence of fats (see CBD and food article).
The key with MCT oil is that it’s an extract rather than the full plant material.
Coconut is technically a fruit and not a tree nut.
Let’s look at just the cannabidiol (CBD) itself.
Allergic responses to the cannabidiol chemical itself.
Keep in mind that for any given substance under the sun, there’s someone somewhere who is allergic to it.
Our immune response is incredibly complex with inputs going back to the womb and maybe even past generations!!
That being said, CBD is a chemical.
It’s not a plant material which is good news.
Our allergic response has been primarily owned by our environment over 100’s of thousands of years.
You don’t find much CBD in the wild although cannabis has been around for 1000’s of years in ancient medicinal use (India and China traditions both have extensive use of it).
On the safety profile of cannabidiol, there are no reported results for allergic reactions.
A good indication of an allergic response to a substance can be found it it’s “side effects” profile.
The four most common side effects are:
- Lower blood pressure
- Dry mouth
The first two are related and point to research showing that CBD lowers blood pressure.
Drowsiness is the opposite effect of an allergic response which is usually an anxious or heightened effect (as we know all too well).
Remember that histamine is excitatory and actually battles GABA to control the sleep/wake cycle (see CBD boost GABA).
Cannabidiol has a powerful anti-anxiety effect which you learn about at the CBD benefits for anxiety article here.
In fact, research is showing that cannabidiol has a powerful ANTI-histamine effect.
There are studies showing that cannabidiol can significantly reduce the symptoms of allergic responses across different systems in the body but most importantly….
It helps to move the immune response from T1 to T2 which is directly tied to allergic responses.
It’s a big reason why your friend can have a cat but you can’t.
Again, if you’re reading about allergies, check out the CBD and histamines article. It’s fascinating.
How to avoid an allergic response to CBD
So here’s the net net.
If you have allergic issues, focus on CBD isolate.
That’s why we deal with CBD isolate at IndigoNaturals.
So many people with allergy or histamine issues are being “sold” on full-spectrum and feeling terrible from it.
That’s going the wrong way!
Stay away from hemp oil and/or as much “plant” material as you can.
Always test first to see how your body responds.
The CBD must absolutely be 3rd party tested free of:
- Heavy metals
- THC (known allergen)
This is a MUST HAVE when choosing CBD.
If the brand doesn’t make this readily available, run. don’t walk.
We actually test our CBD oils twice (once at the biomass and again for the finished product).
The goal is better health after all.
Let’s look at specific questions that come up with CBD and allergies.
Can you get allergic hives from CBD
Yes but the same rules we discussed above hold true.
Our histamine pathway is system-wide.
It may rear its ugly head is specific areas (skin versus stomach versus sinuses, etc) but the chemical pathway is pretty similar.
Hives is just an allergic reaction in our skin.
This may apply more for topical applications directly to the skin or it can be systemic (think of how poison oak moves around the body).
You can test CBD oil directly on the skin to see how you react.
We always recommend going slow when starting anyway. Check out our How to Take CBD article.
We’ve seen countless situations where a person has an allergic response to full-spectrum CBD or hemp oil which goes away with CBD Isolate.
Just read our reviews. Half of them involve this positive difference in response.
That’s the primary reason we created IndigoNaturals. nearly full bottles of very big brands are lying around in a box somewhere.
Can dogs or cats be allergic to CBD
Nature’s pretty amazing.
When it finds something that works, it keeps it!
Every mammal has limbs composed of 1 large upper bone, connected to 2 lower limb bones, connected to a section of smaller “rock-line” bones and then 5 digits.
It’s the same blueprint in us, a bat, a horse, or a whale.
- The horse’s hoof is one giant toenail (the other digits are shrunken).
- The bat’s wing has elongated digits with the skin between for wings.
- The whale has shrunken all of this inside of a flipper.
Pretty cool!! But we digress!
We share more than this with dogs and cats.
Most multicellular creatures have an endocannabinoid system that CBD interacts with.
It’s dated at about 600,000 years old.
Sorry insects, you came too early to the party!
Dogs and cats also have very similar pathways to us in terms of how CBD works.
They share allergic responses as well since those pathways are the same although probably more robust in cats and dogs.
The same rules above hold true for cats and dogs in terms of allergies to CBD in its different forms!
CBD Isolate in MCT oil (just two ingredients) with no other additives here:
Always work with a doctor or naturopath with any supplement!
The information provided here is not intended to treat an illness or substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.Learn why the type of CBD you take can cause a very different allergic response. Can You Be Allergic to CBD?
Can you have an allergic reaction to CBD oil?
Copy article link to clipboard.
Link copied to clipboard.
- CBD oil overview
- Allergies in the body
- Allergic reactions to CBD oil
- Can CBD oil help with allergies?
Whether it’s sniffling, watery eyes, itching, or asthma, many of us are all too familiar with symptoms of allergies.
According to the Asthma and Allergy Foundation of America, allergies are the No. 6 cause of chronic illness in the United States. To narrow that down,there were 19.9 million adults diagnosed with hay fever in 2017, according to the Centers for Disease Control and Prevention (CDC). It is estimated that 32 million Americans live with food allergies; more than 170 foods may lead to allergic reaction.
Considering the increasing awareness and use of cannabidiol (CBD) and the existing potential for pollen and food allergies, allergy sufferers may wonder whether they are at risk for an allergic reaction to CBD oil or whether CBD can provide treatment or relief for other types of allergic reactions.
Though there’s not much in the way of allergy research specifically for CBD oil at this point, the cannabis plant itself has been linked to allergic reactions.
“Marijuana is a plant and produces pollen and one can become allergic to the pollen and the plant, especially if one has pre-existing allergic tendencies,” said Dr. William S. Silvers, clinical professor of medicine in allergy and immunology at the University of Colorado School of Medicine.
That being said, only male marijuana plants produce pollen, and are exceedingly rare in cannabis and hemp production because they produce less oil and CBD than female plants. Therefore, a consumer’s exposure to pollen would be extremely rare.
CBD oil overview
CBD is the second-most-prominent cannabinoid derived from the cannabis plant, after the intoxicating cannabinoid THC. CBD oil, extracted from marijuana or industrial hemp, has gained popularity for its potential benefits for a number of conditions, including inflammation, arthritic pain, depression, seizures, and anxiety.
There’s not much in the way of allergy research specifically for CBD oil, but the cannabis plant itself has been linked to allergic reactions in some people. Photo by: Gina Coleman/Weedmaps
Though research is still limited in regards to many supposed benefits, in 2018 the FDA approved Epidiolex, a CBD oral solution, to treat seizures associated with two severe types of epilepsy, Dravet syndrome and Lennox-Gastaut syndrome.
Allergies in the body
A properly functioning immune system works to protect the body from pathogens such as bacteria, viruses, and fungi, and attack these unwanted microorganisms in order to help prevent disease. In the case of allergies, the immune system reacts to plant pollen and other substances in the environment to trigger the body’s defense mechanisms. The result, depending on the type of allergy, can be a variety of symptoms, including itchy eyes, runny nose, asthma, hives, skin itching, or more severe reactions such as anaphylaxis, which can be life-threatening.
Allergic reactions to CBD oil
Humans commonly experience allergic reactions to many kinds of plant pollen. However, only male cannabis plants produce pollen, whereas female plants are more widely used for oil and cannabinoid production. Large-scale industrial hemp fields may include a variety of mature males (pollen) as well as fertilized females (oil and seeds). The impact of hemp pollen on everyday consumers, as well as the communities that work and live near these production facilities, has not been studied.
People can also develop allergies to some of the terpenes found in cannabis. For instance, researchers from the Duke University School of Medicine found that about 20% of the 100 people they tested had an allergic skin reaction to linalool, whereas 8% had reactions to limonene. These kinds of contact allergies may not be common in the general population, but individuals who are employed in the production of cannabis products and CBD oil could be more at risk.
In addition to the skin, the lungs are another target for allergic reactions to terpenes. Assessing the risk is somewhat complicated because some terpenes are irritants, whereas others, such as eucalyptol, may actually provide a protective, anti-inflammatory role and might help to control inflammatory diseases like asthma and COPD.
Dr. Gordon Sussman, an allergist in Canada and professor at the University of Toronto, said there is very little published research on CBD oil allergies.
“It’s an unknown area at this point,” he said. “But we know that cannabis sativa is an allergen and we know that it’s a common allergen.”
Humans commonly experience allergic reactions to many kinds of plant pollen. Only male cannabis/hemp plants produce pollen. Most cannabis products, including CBD oil, are made using female cannabis plants. Photo by: Gina Coleman/Weedmaps
He said that cannabis allergies, like other forms of allergies, can worsen as exposure to the allergen continues. Most people with cannabis allergies suffer from a runny and stuffy nose (rhinitis), eye irritation (conjunctivitis), and sometimes wheezing, Sussman explained. But there have been cases of more severe reactions such as anaphylaxis, which have primarily resulted from ingestion of hemp seeds.
According to a letter entitled “Marijuana and stoned fruit,” written by medical doctors from the University of California, San Diego, and published in the Annals of Allergy, Asthma, and Immunology on Feb. 2, 2018, a 24-year-old man who smoked marijuana daily visited their allergy clinic two weeks following an anaphylactic reaction after eating yogurt with hemp seeds.
“This was his first known ingestion of hemp seeds. Immediately after consumption, he developed oral pruritus [itching] that progressed to shortness of breath, facial swelling, and pre-syncope [sensation prior to fainting],” the letter stated.
Those with food allergies may also be susceptible to cross-reactivity.
“You can have a cross-reaction with certain foods that share certain antigens, certain components, with the cannabis plant itself,” Silvers said.
Such foods may include tomatoes and stone fruits containing pits such as peaches, he said. It’s a similar cross-reactivity to what is seen in people with ragweed allergies who might experience symptoms such as itchy mouth if they eat fruit in the melon family, he added.
“The same thing goes with cannabis and tomatoes and peaches and almonds and a number of other foods … eggplant, grapefruit, apples,” Silvers said.
There is no clinical evidence CBD oil can help allergies. Photo by: Gina Coleman/Weedmaps
A 2013 study from the “Internal Archives of Allergy and Immunology” tested 21 patients with food allergies for reactivity to cannabis lipid transfer proteins (LTPs), which are probable allergens. Twelve of the 21 test subjects were allergic to cannabis, and all 12 had more severe reactions to food allergy than those without a cannabis allergy. A 2008 study, also from “Internal Archives of Allergy and Immunology,” tested 32 subjects for an allergic reaction to cannabis LTPs, as well as tomato, peach peel, and pollen extracts. The study found that all test subjects sensitive to tomato allergens were also sensitive to cannabis. There was also cross-reactivity noted with peach peel.
Silvers said that the type of allergic reaction depends on the type of exposure. In addition to cannabis pollen allergies and food-based allergies, skin allergies are also a possibility.
“Touching the plant can very easily develop a dermatitis, itching, and skin reactions,” he said.
Can CBD oil help with allergies?
While there isn’t much research supporting the idea that CBD oil can help the discomfort associated with common allergy symptoms, there is some research related to its general effects on inflammation, which is part of the body’s allergic reaction process.
A 2011 research report published in the journal Free Radical Biology and Medicine examined the potential role of CBD in various inflammatory-type conditions. George W. Booz, a professor in the department of pharmacology and toxicology at the University of Mississippi Medical Center, concluded in the report: “Inflammation and oxidative stress are intimately involved in the genesis of many human diseases. Unraveling that relationship therapeutically has proven challenging, in part because inflammation and oxidative stress ‘feed off’ each other. However, CBD would seem to be a promising starting point for further drug development given its antioxidant (although relatively modest) and anti-inflammatory actions on immune cells … .”
According to Silvers, there is no clinical evidence CBD oil can help allergies and, while experimental laboratory research suggesting anti-inflammatory effects exists, there’s no clinical patient substantiation.Can you have an allergic reaction to CBD oil? Copy article link to clipboard. Link copied to clipboard. Contents CBD oil overview Allergies in the body Allergic reactions ]]>