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cbd and glioblastoma

CBD shows promise for fighting aggressive brain cancer

by Experimental Biology

The researchers believe that CBD’s anti-cancer actions target mitochondria — the cell’s energy producing structures — by causing the mitochondria to dysfunction and release harmful reactive oxygen species. The mitochondria (teal color) in a canine cancer cell line are shown after 48 hours of treatment with a nonlethal dose of CBD isolate (40x objective lens). Credit: Chase Gross, Mando Ramirez, Jade Kurihara, Colorado State University

Findings from a new study examining human and canine brain cancer cells suggest that cannabidiol could be a useful therapy for a difficult-to-treat brain cancer. Cannabidiol, or CBD, is a non-psychoactive chemical compound derived from marijuana.

The study looked at glioblastoma, an often-deadly form of brain cancer that grows and spreads very quickly. Even with major advancements in treatment, survival rates for this cancer have not improved significantly.

“Further research and treatment options are urgently needed for patients afflicted by brain cancer,” said Chase Gross, a student in the Doctor of Veterinary Medicine/Master of Science program at Colorado State University. “Our work shows that CBD has the potential to provide an effective, synergistic glioblastoma therapy option and that it should continue to be vigorously studied.”

Mr. Gross was scheduled to present this research at the American Society for Pharmacology and Experimental Therapeutics annual meeting in San Diego this month. Though the meeting, to be held in conjunction with the 2020 Experimental Biology conference, was canceled in response to the COVID-19 outbreak, the research team’s abstract was published in this month’s issue of The FASEB Journal.

Mr. Gross and colleagues examined human and canine glioblastoma cells because the cancer shows striking similarities between the two species. They tested the effects of CBD isolate, which contains 100 percent CBD, and CBD extract, which contains small amounts of other natural occurring compounds such as cannabigerol and tetrahydrocannabinol, or THC.

A bright field microscopy image (10x) illustrating the swollen intracellular vesicles observed after 48 hours of treatment with a lethal dose of CBD (10x objective lens). Swollen vesicles were a hallmark of CBD-induced cell death in all the cell lines studied. Credit: Chase Gross, Mando Ramirez, Colorado State University

“Our experiments showed that CBD slows cancer cell growth and is toxic to both canine and human glioblastoma cell lines,” said Mr. Gross. “Importantly, the differences in anti-cancer affects between CBD isolate and extract appear to be negligible.”

The new work revealed that the toxic effects of CBD are mediated through the cell’s natural pathway for apoptosis, a form of programmed cell death. The researchers also observed that CBD-induced cell death was characterized by large, swollen intracellular vesicles before the membrane begins to bulge and breakdown. This was true for all the cell lines studied.

The researchers believe that CBD’s anti-cancer actions target mitochondria—the cell’s energy producing structures—by causing the mitochondria to dysfunction and release harmful reactive oxygen species. Their experiments showed that cells treated with CBD exhibited significant decreases in mitochondrial activity.

“CBD has been zealously studied in cells for its anticancer properties over the last decade,” said Mr. Gross. “Our study helps complete the in vitro puzzle, allowing us to move forward in studying CBD’s effects on glioblastoma in a clinical setting using live animal models. This could lead to new treatments that would help both people and dogs that have this very serious cancer.”

Next, the researchers plan to transition from cell cultures to animal models to test CBD’s effects on glioblastoma. If the animal studies go well, the work could progress to clinical trials on dogs that are being treated for naturally occurring glioblastoma at the Colorado State University Veterinary Teaching Hospital.

CBD shows promise for fighting aggressive brain cancer by Experimental Biology The researchers believe that CBD’s anti-cancer actions target mitochondria — the cell’s energy producing

Early Research Finds CBD May Help Combat Brain Cancer

Researchers studying dog and human cell cultures found cannabidiol was effective at combating glioblastoma.

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Researchers studying canine and human cell cultures found that cannabidiol, or CBD, was effective at combating the highly aggressive form of brain cancer known as glioblastoma.

People diagnosed with glioblastoma generally have a poor prognosis, and recent research advances have failed to significantly improve their survival rate.

“Further research and treatment options are urgently needed for patients afflicted by brain cancer,” Chase Gross, a student in the doctor of veterinary medicine and master of science program at Colorado State University, said in a press release. “Our work shows that CBD has the potential to provide an effective, synergistic glioblastoma therapy option and that it should continue to be vigorously studied.”

Publishing their findings in The FASEB Journal, Gross and his colleagues studied human and canine glioblastoma cells. They tested the effects on these cells of CBD isolate, which is 100% CDB, and CBD extract, which also contains small amounts of other naturally occurring compounds.

The scientists found that CBD slowed the growth of glioblastoma cells taken from both humans and dogs. There appeared to be a negligible difference between the CBD isolate and the CBD extract when it came to this effect.

“CBD has been zealously studied in cells for its anticancer properties over the last decade,” said Gross. “Our study helps complete the in vitro puzzle, allowing us to move forward in studying CBD’s effects on glioblastoma in a clinical setting using live animal models. This could lead to new treatments that would help both people and dogs that have this very serious cancer.”

Gross and his colleagues plan to assess CBD’s effects in animals with glioblastoma. Pending success in such research, they hope to begin clinical trials of CBD as a treatment for the brain cancer in dogs at the Colorado State University Veterinary Teaching Hospital.

To read a press release about the study, click here.

Researchers studying dog and human cell cultures found cannabidiol was effective at combating glioblastoma. ]]>