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Can CBD protect you and help you get better from Lyme disease?

Can CBD protect you and help you get better from Lyme disease?

Can CBD protect you and help you get better from Lyme disease? I’m Dr. Mary Clifton. I’m an internal medicine doctor and an expert in CBD and other cannabinoids.

THE PEARLS

[0:20] Lyme disease is a complicated chronic infection with considerable ongoing chronic inflammation, both in the skin and in the joints, but also involving the central nervous system in the brain and spinal cord.

[2:35] The CBD can definitely get in the brain. Then, the question is what can it do to modulate the inflammation? It can do a lot.

[3:15] Very preliminary data suggests that you can see significant symptom reduction with pretreatment with CBD before exposure to colds and flu, and also significant symptom reduction after you’ve gotten sick when adding CBD.

[3:58] There is a significant amount of immune modulation that can be seen with administration of CBD.

THE FULL TRANSCRIPTION

Can CBD protect you and help you get better from Lyme disease? I’m Dr. Mary Clifton. I’m an internal medicine doctor and an expert in CBD and other cannabinoids.

Lyme disease is a complicated chronic infection with considerable ongoing chronic inflammation, both in the skin and in the joints, but also involving the central nervous system in the brain and spinal cord. Controlling inflammation and immune response in settings of chronic diseases like this is a very important part of controlling the symptoms of the chronic disease. That may be exactly what CBD could do for you.

It crosses the blood-brain barrier and can treat conditions in the brain fairly easily because it easily crosses that barrier. It also reduces inflammatory cytokines, and it changes overall in the response. The blood-brain barrier is a very tight, restrictive barrier around the brain and spinal cord that limits the flow and the ready communication between the body and the brain. It’s very important to do that because we need highly functioning brains and spinal cords to do our jobs as human beings.

But the problem is, when you’re sick, things can’t get in and out. It’s hard for antibiotics or antivirals to cross that blood-brain barrier. We often have to use very high doses for long periods of time, but in situations like multiple sclerosis, Lou Gehrig’s disease, Alzheimer’s, and probably also Lymes, when there’s chronic inflammation in the brain, the blood-brain barrier becomes a little less restrictive and products are able to flow a little more readily.

But even if the blood-brain barrier wasn’t impacted, we know that cannabinoids cross that barrier easily. We have data on reductions in central nervous system symptoms like insomnia or anxiety in as little as just a few minutes after administering cannabinoids like THC or CBD. The CBD can definitely get in the brain. Then, the question is what can it do to modulate the inflammation? It can do a lot.

All kinds of cytokine production are significantly reduced in the setting of CBD, particularly IL-17. The interleukins and the tumor necrosis factors, the cytokines, are the chemicals that your body makes that make you feel terrible when you’re sick. They’re the chemicals that give you the fever and the body aches, the loss of appetite, so by regulating the production of those chemicals, you can actually see a significant reduction in the symptoms that you’re dealing with.

Very preliminary data suggests that you can see significant symptom reduction with pretreatment with CBD before exposure to colds and flu, and also significant symptom reduction after you’ve gotten sick when adding CBD. There’s other data that’s been done over the course of three years, but on very low numbers of human subjects, that show modulation in the immune system and all kinds of ways with the administration of CBD, changes in B cells, T cell function, natural killer cell function, of reductions in IgM and IgG in the immunoglobulins, the antibodies that the body creates to infection.

There is a significant amount of immune modulation that can be seen with administration of CBD. If you’re dealing with a chronic immune condition, it may be worthwhile talking to your doctor or with a cannabinoid expert who could give you some advice on how to potentially use these products to improve your overall health and potentially reduce the symptoms that you’re dealing with related to your chronic medical condition .

DR. MARY CLIFTON

Dr. Mary Clifton is an Internal Medicine doctor with 20 years of experience in both the hospital and private practice and a recognized expert in CBD, Cannabis, and Medical Marijuana. She is a published researcher, national speaker on women’s health and osteoporosis, and author of four books, and two new soon-to-be-released books on CBD and Cannabis – what you need to know, how to use them and a COOKBOOK to support ease of use.

Lyme disease is a complicated chronic infection with considerable ongoing chronic inflammation, both in the skin and in the joints, but also involving the central nervous system in the brain and spinal cord. Lyme disease & CBD.

Can medical marijuana help treat Lyme disease? A doctor’s perspective.

by Daniel A. Kinderlehrer, M.D.

I have a confession to make. I proposed a talk on medical marijuana at ILADS because it would force me to learn everything I could on the topic. I live in Colorado where it seems there is a dispensary on every corner, and many of my patients have been using medical cannabis. But the huge assortment of products is confusing, and I wanted to give specific recommendations to help patients get the most benefit. Here is what I learned.

Marijuana has 483 phytocannabanoids, which are naturally occurring compounds that can affect many body processes such as appetite, mood and sleep. Most people have heard of one of them—THC, or tetrahydrocannabinol—the psychoactive component of marijuana. THC can make you high, giddy, or euphoric, and provide seemingly awesome universal insights that may appear quite trivial the next day.

Some strains of marijuana now available are not your father’s weed—they have a much higher THC content. It’s important to choose the appropriate strain for your needs, and some people may want to avoid THC entirely. However, it has been clearly established that THC is quite beneficial for pain, sleep, nausea, appetite, and PTSD, so there are medically valid reasons for choosing it.

Most of the non-THC phytocannabanoids fall into the category of cannabidiols, or CBDs. CBDs were once considered to be physiologically inactive unless paired with THC, but it turns out that is not the case. There is compelling scientific research documenting its independent activity, and now there is extensive clinical experience as well.

Did you know that we make our own CBDs? All vertebrates going back 600 million years on the evolutionary tree have an endocannabanoid system, which modulates immune and nervous system function. CBDs are potent anti-inflammatory agents, they regulate neurotransmitters, and they may enhance immune competence. CBDs decrease neuroinflammation and are neuroprotective. They can significantly reduce pain and anxiety.

Marijuana is not the only product that supplies CBDs. Hemp, a variety of cannabis that is used to make rope, fabric and paper, contains CBDs. Hemp has less than 0.3% THC, and is not psychoactive.

There are two strains of cannabis: indica and sativa. Indica is great for pain but is sedating, so it is best used in nighttime. Sativa is activating, can increase energy, and is better suited for daytime use. The difference between indica and sativa is another ingredient, terpenes. Terpenes modify the activity of CBD and THC. There are also a number of hybrid strains now available that essentially cross categories.

If your problem is pain, consider taking CBDs in the form of hemp oil in the daytime. My patients have had excellent responses to a liposomal sublingual extract (taken under the tongue), and it is activating, not sedating. In the evening, you can take a marijuana extract with equal parts THC and CBD, since these together will have additive pain-relieving effects. There are a number of delivery systems available, including smoking, vaping, edibles and sublingual extracts. I recommend the extracts since the onset is reasonably quick, usually in about 30 minutes, and the dose can be easily titrated by adjusting the number of drops under the tongue.

Both hemp-derived CBD and marijuana are available as balms that can be applied topically to relieve pain. Whether taken systemically or applied locally, these products can help many patients significantly decrease their need for pain medication. In fact, states that have legalized medical marijuana have experienced a 25% decrease in opiate overdose deaths. That’s right. This scourge, which took 42,000 lives in 2016 (66,000 including all drug overdose deaths), was significantly reduced by the availability of marijuana.

For sleep, take a THC-dominant indica strain. THC is not only sedating, it increases the time spent in the deeper stages of sleep, so sleep is more restorative. If your problem is difficulty falling asleep, use a short-acting vehicle like vaping, which kicks in within 15 minutes. Vaping is high-tech smoking without the ill effects of the smoke. Alternatively, use a sublingual extract, which has an onset within 30 minutes. Both of these will hang around for up to an hour.

If your problem is staying asleep, then take an edible. It takes 60-90 minutes to get into the circulation, and hangs around for an average of 3-4 hours. I don’t recommend cookies or candy, as they usually have a lot of junk in them—you can take pure THC tablets. The average dose is 10mg, but start with 2.5mg to see how well you tolerate it.

If you have problems with both sleep initiation and maintenance, you can take sublingual extract or vape to fall asleep, and a THC tablet to stay asleep. The table below includes some considerations for choosing among the available options.

While THC is only available in states that have legalized medical marijuana, CBD from hemp oil is available everywhere—although the attorney general in Nebraska seems to be confused about that. You can buy it on the Internet, travel across state lines, and I have even taken it out of the country when I traveled to Israel to visit my daughter.

CBD can lessen anxiety, without any of the psychoactive giddiness of THC. CBD is anti-inflammatory—it not only decreases pain, it can improve energy, cognitive function and general well being. When I started selling it in my office, it went flying off the shelf. The full effects of CBD from hemp oil do not kick in for two to three weeks.

While properly administered marijuana has been extremely effective in helping people with PTSD, in some people it will make anxiety worse. Similarly, THC can help depression in some people, but in others can make depression worse, particularly if it is abused by chronic users. If you develop tolerance to the benefits of cannabis because of chronic use, it is important to take a drug holiday. Pregnant women should not take marijuana.

The legal status of marijuana is dicey. It is unjustifiably classified as a Class I controlled substance by the Food and Drug Administration, in the same category as heroin, and the Obama administration declined to enforce federal laws regarding marijuana in states where it was legalized and properly regulated. The current administration is trying to change that, but I predict it will be like trying to put toothpaste back in the tube.

The analgesic, anti-inflammatory and neuroprotective properties of cannabis make it extremely valuable as an adjunct to the treatment of tick-borne diseases. There is a lot of research available on the medical uses of cannabis. A couple of good resources are listed below.

Kowal MA et al. Review on clinical studies with cannabis and cannabinoids 2010-2014. Cannabinoids 2016;11(special issue):1-18

Dr. Daniel Kinderlehrer specializes in the treatment of tick-borne disease in Denver, Colorado. He has found that properly administered medical marijuana and CBD from hemp oil have been extremely beneficial for many of his patients.

A Colorado Lyme doctor reports that properly administered medical marijuana and CBD from hemp oil have been extremely beneficial for many of his patients.