What You Need To Know About CBD If You Take Antidepressants
ThereвЂ™s no denying that CBD, aka cannabidiol, was the reigning trend of last year, and shows no signs of stopping. From edible products and tinctures, to bath and beauty products, CBD was (and is) everywhere. Though touted as a natural, holistic, and safe way to manage a variety of health issues, you may be wondering if you can take CBD and antidepressants together. And while CBD is touted as an all-natural supplement with some evidence that it can be good for your health, it’s possible that your CBD latte can still impact the efficacy of different medications вЂ” including antidepressants.
According to statistics from the National Alliance on Mental Illness (NAMI), one in five U.S. adults live with a mental illness in any given year. Furthermore, as NBC News reported, a 2016 study revealed one in six people in the U.S. take some type of psychiatric medication, with antidepressants being the most widely prescribed. Limited research has shown that CBD may help alleviate symptoms of anxiety and sleep issues, as well as lower levels of inflammation in the body, though this research (and the dosages needed for these effects) is nowhere near conclusive. And that means you need to be careful if you’re choosing to consume it.
вЂњGenerally speaking, you can safely use CBD supplements when youвЂ™re taking antidepressants. However, there are a couple concerns,вЂќ Peter Grinspoon, M.D., an instructor in medicine at Harvard Medical School, and the author of the memoir Free Refills: A Doctor Confronts His Addiction, tells Bustle. вЂњThe first concern is that CBD isnвЂ™t regulated by the FDA. You have to be careful that the CBD youвЂ™re getting is from a reliable supplier. For example, Consumer Reports recently put out an article on how to go shopping for CBD because theyвЂ™ve done tests, and found some [supplement] formulations had no CBD. Some were inaccurately labeled, and other formulations even had some THC in them.вЂќ (THC is the cannabis compound that, unlike CBD, can get you high.)
The recent passing of the bipartisan Farm Bill legalized the production of hemp on an industrial scale for the first time in the U.S. вЂ” which means itвЂ™s that the CBD industry will only continue to grow. However, this doesnвЂ™t necessarily mean there will be more oversight or required research.
So, what can potentially happen if you take CBD when on antidepressants? Unfortunately, because thereвЂ™s a limited amount of studies to draw from, Grinspoon says, вЂњCBD does have hypothetical drug interactions; the question is whether these are clinically important or not.вЂќ
The reason for this is that CBD inhibits two main enzyme systems, Grinspoon explains. Enzymes are proteins that speed up chemical reactions in the body, and play an important role in functions like digestion and respiration. They also help you metabolize antidepressants. вЂњOne system is the same one that grapefruit inhibits вЂ” the technical name is the CYP34A enzyme system. So, just like grapefruit juice, CBD can cause your body to have higher doses of benzodiazepines [anti-anxiety medications], or certain antipsychotic medications,вЂќ Grinspon explains.
WhatвЂ™s more, Grinspoon says that CBD also inhibits вЂњthe system that metabolizes a lot of serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and antipsychotics as well.вЂќ Meaning, taking CBD supplements while on these psychiatric medications could hypothetically interfere with how these medications are metabolized.
Despite this, Grinspoon explains that this is typically not a large cause of concern for a majority of people on antidepressants or other psychiatric medications. вЂњCertainly, if someone is on a very delicately balanced medical regiment, CBD could knock that out of whack because of the two different enzyme systems it inhibits. In terms of actual clinical practice, I havenвЂ™t heard any stories of people having clinical decompensation because of adding CBD to their regime,вЂќ he says.
When it comes down to it, Grinspoon says that the potential interactions should be regarded as more вЂњhypothetical than real,вЂќ and that the side effect profile of CBD is вЂњvery minimal.вЂќ Of course, itвЂ™s always good to have a conversation with your physician about potential interactions, and to disclose any prescribed or over-the-counter medications and supplements you are taking. At the end of the day, using CBD supplements while on antidepressants is an individual choice, but it’s important to go in informed.
Readers should note that the regulations and data surrounding marijuana, CBD, and other related products are still developing. As such, the information contained in this post should not be construed as medical or legal advice. Always consult with your doctor before trying any substance or supplement.
ThereвЂ™s no denying that CBD, aka cannabidiol, was the reigning trend of last year, and shows no signs of stopping. From edible products and tinctures, to bath and beauty products, CBD was (and is) everywhere. Though touted as a natural, holistic,вЂ¦
Cbd oil and effexor
I tried it and it literally dulled the withdrawal by at least half. It made my days tolerable to the point that I could go to work and function like a human being.
Aside from the dizziness and head fog, the most unsettling side-effect of Effexor withdrawal was the ease with which I would become very angry. I’m NOT an angry person. At all. Also the. I hesitate to say “suicidal” thoughts because I don’t think that’s what it was. It was more of an indifference towards whether I lived or died.
After a few months it became clear to me that I still needed something, though nothing as strong as Effexor. Now I’m on a very low dose (10 mg) Lexapro. Combined with regular exercise I seem to have struck the right balance.
I am ever surprised that they continue prescribing that one. Of the 10 I’ve been on that one was the harshest by far (though many others also had severe, dangerous side effects).
Background: I’ve lived my entire adult life (and most of my teens) with severe chronic depression. In my early 20’s I started taking pharmaceutical treatment, and once I found the right drug (after trying many over the course of years) my life became manageable. SSRIs helped but I experienced severe nausea on most of them, or worse. It was only when I tried SNRIs like Effexor that things started to get better. YMMV, IANAPsychiatrist, etc, etc.
A few years ago I switched from Effexor to Cymbalta. Same class of drug – The Effexor simply wasn’t helping as much as it used to and the switchover was done with a long taper-down and replace period. I even bought a lab-grade scale to measure out the contents of the capsules so I could cross-over smoothly.
All that said, Cymbalta has the same withdrawal effects, on about the same time scale – a single missed dose. But I wouldn’t give it up unless something better comes along. I still struggle with my depression and the SNRI is just one tool in my toolbox for managing it.
I used to err on the side of double-dosing rather than miss a dose if I wasn’t sure, it is an absolute hell of a dependency.
What exactly did the psych recommend it for? Depression?
It’s kind of an issue these days because having something that’s lower in THC and has CBD in it isn’t as marketable as something with higher THC even though it would likely be a more enjoyable and relaxing high for most people. I believe CBD cannibalizes the THC to some degree so generally the higher the THC percentage in the plant the lower the CBD is, and even for someone with lots of experience it will give you more anxiety/paranoia.
Cbd oil and effexor I tried it and it literally dulled the withdrawal by at least half. It made my days tolerable to the point that I could go to work and function like a human being. Aside