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Why may Cannabis be a practical option?

It is known that bladder activity is the function of both the central and peripheral nervous system, and cannabinoid receptors are present both in the central and peripheral nervous system.

Also, these receptors are activated by compounds similar to those found in the cannabis plant. These findings can be the beginning of more extensive research concerning cannabis and incontinence. But more data is needed regarding clinical efficacy.

However, considering the cannabis-related products are now widely available and most of them are safe for prolonged use, they may be helpful for many individuals living with OAB.

Bladder control and cannabis

The 2010 study discovered the specific cannabinoid receptors and a family of the ligand within those receptors in the bladder acting in accordance with the “lock and key” theory 1 . More recent findings seem to confirm the link between cannabinoid receptors and bladder regulation.

Due to these receptors, cannabis works directly with natural cannabinoid receptors in the bladder control pathways. This means that the cannabis plant may improve urinary incontinence conditions.

But, of course, more extensive research is needed.

Clinical trials findings

Several clinical trials findings showed that taking of cannabis-originated extracts improves bladder control. For example, the researchers at Oxford’s Center for Enablement discovered that administration of cannabis improved the condition of patients with OAB 2 .

Other studies showed that people suffering from Multiple sclerosis experience decreased urinary urgency, frequency and urination at night when using cannabis 3 .

Also, the experts concluded that the use of cannabis extracts might reduce OAB in patients who were previously treatment resistant 4 .

Side effects reported

Currently, we do not have approved cannabis-derived medication to help with OAB. This work is still in progress. But some clinical trials are being conducted. The patients who agreed to participate in trials were treated with THC/CBD capsules or oromucosal spray.

These findings look quite optimistic, but further assessment and data control are needed. Anyone with OAB who has decided to try cannabis as a treatment should consult with a doctor and discuss all potential risks and benefits to avoid unpleasant conditions.

References

  1. Tyagi P, Tyagi V, Yoshimura N, Chancellor M. Functional role of cannabinoid receptors in urinary bladder. Indian J Urol. 2010;26(1):26-35. doi:10.4103/0970-1591.60440
  2. Wade DT, Robson P, House H, Makela P, Aram J. A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. Clin Rehabil. 2003;17(1):21-29. doi:10.1191/0269215503cr581oa
  3. Brady CM, DasGupta R, Dalton C, Wiseman OJ, Berkley KJ, Fowler CJ. An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis. Multiple Sclerosis Journal. 2004;10(4):425-433. doi:10.1191/1352458504ms1063oa
  4. Maniscalco GT, Aponte R, Bruzzese D, et al. THC/CBD oromucosal spray in patients with multiple sclerosis overactive bladder: a pilot prospective study. Neurol Sci. 2018;39(1):97-102. doi:10.1007/s10072-017-3148-6

Why may Cannabis be a practical option? It is known that bladder activity is the function of both the central and peripheral nervous system, and cannabinoid receptors are present both in the

CBD Effects on the Bladder

Posted on August 16th, 2020

While research on the effects of CBD on the bladder is still in the early stages, one of the most interesting finds was the fact that the Endocannabinoid System (ECS) also exists in the urinary bladder. That is why a lot of people used to assume that, when it comes to bladder control, there might be ECS signaling involved. There was also widespread speculation that the binding of this ECS with the cannabinoid receptors might have the effect to relax the human bladder, particularly when filling up.

Another speculation was that the dysregulation of the endocannabinoid system in the bladder might be responsible for other ailments as well. These might include Detrusor Overactivity and the aetiopathogenesis of the Overactive Bladder Syndrome (OAB). More and more research is revealing the full range of potential health benefits that cannabinoids, in particular cannabidiol, may offer. Since hemp-derived CBD was legalized, researchers are becoming interested in what this cannabinoid may have to offer. As a result, there have been many exciting discoveries. One recent discovery was that CBD might be able to help bladder ailments, particularly females suffering from an overactive bladder. About this, it’s mainly urogynecologists who are beginning to pay attention.

Does CBD Have A Positive Effect on the Bladder?

Based on available statistics out there, more than 20 million women are suffering from an overactive bladder as of now. In general, this can be an important issue, particularly for women with an extremely active lifestyle. They may have to urinate regularly, and this may often result in embarrassment and also emotional stress. In a worst-case situation, a woman may have to significantly change her routine to prevent a scenario with her overactive bladder.

Generally speaking, there are various things that they won’t be in a position to do because of all the persistent bladder issues. If you’re a woman struggling with this condition, the bladder muscles may contract spasmodically. In most cases, this may happen suddenly without prior warning. This may give a woman the feeling that she needs to urinate immediately. For any person who has been in this situation before, they’ll know that the detrusor muscles’ contractions are powerful. In turn, this can lead to fluids leaking past the sphincter muscles; its primary role is to prevent fluids from getting through.

What Do Studies Say About CBD Effects on the Bladder?

In the last decade, several studies have looked at the effects of CBD. Some have suggested that CBD ingested orally may impact the signaling function of the bladder and the brain. Other research even suggests that CBD may play a vital role in reducing the number of misfires. This is a common cause of many female bladder issues.

Typically, in a normal human bladder, the detrusor muscles remain relaxed, provided the urine’s storage is in that cavity. If fluids need to be released from the bladder, the muscles will contract. If there are issues with the signaling process, it might lead to the detrusor muscles going into spasm and irregular contractions. It also leads to the unplanned leakage of fluids; this can happen at very inconvenient times.

In several research studies, it has been found that the body consists of CB1 and CB2 receptors for cannabinoids. These receptors are found throughout the body, including the bladder. Both of these receptors work with the detrusor muscles on various levels. In fact, most of the efforts with many researchers are now on finding evidence that these receptors affect urination. For this reason, manipulating these receptors with the application of CBD could potentially be useful to those women who are struggling with OAB.

Interstitial Cystitis

More than 4 million U.S. citizens struggle with a chronic bladder disease known as interstitial cystitis. Very little is known regarding the cause of this disease; however, statistics imply that middle-aged women are often the most at risk of acquiring it.

The interstitial cystitis symptoms, also known as painful bladder syndrome (PBS), entail a similar discomfort to that of urinary tract infections. It also may show increased sensitivity to pain and chronic inflammation of the bladder. On average, a person is said to void liquid about seven times per day ; however, urination frequency may usually reach 60 times every 24 hours for cystitis sufferers.

As opposed to urinary tract infections, a bacterial infection is not a cause for painful bladder syndrome; this means antibiotics are of no assistance. What’s more, there’s no approved cure for the disease. However, there are a variety of options available for those wishing to relieve their chronic symptoms. In general, bladder installation is one of the common forms of treatment. Also called a bladder wash, the procedure generally involves applying a catheter for filling the bladder with a specific solution. This solution is usually dimethyl sulfoxide (DMSO).

Research also claims that factors such as exercise and diet can help reduce inflammation and the associated discomfort. However, a study printed on the Journal of Neurology discovered that cannabinoids might also be of benefit . The study showed that the use of a cannabinoid receptor 2 agonist may play a significant role. In particular, it might affect cystitis and inhibited bladder inflammation related to increased urinary frequency.

Can CBD Be Used for Overactive Bladder Conditions?

Understandably, most women who struggle with OAB are anxiously awaiting to get some relief for this particular condition. However, in most cases, extensive medical research will need to be done before a doctor can prescribe CBD for OAB. Nevertheless, there are lots of positive indications when it comes to CBD use.

The American Academy of Neurology (AAN) recently conducted a study and realized that CBD may be able to help alleviate symptoms of multiple sclerosis; basically, this included OAB and spasticity. Nevertheless, there are several other considerations on the effects of CBD, such as memory loss, seizures, mental impairment, and depression.

In fact, many other potential benefits associated with CBD have already been revealed. These potential benefits include pain relief, nausea control, appetite stimulation, and muscle spasms. At this point, it’s essential to know that the FDA hasn’t yet approved cannabidiol for any health condition or disease, except the drug Epidiolex, which is used to treat a rare form of seizures. Future research may discover that CBD could be helpful for the symptoms of OAB.

How Might CBD Lower Inflammation and Urinary Frequency?

A team of researchers from the Wisconsin-Madison University used mice as models to investigate if activation of CB2 receptors can inhibit the severity of induced cystitis . They were also looking for the potential impact of cannabinoids in relation to inflammation-associated pain and urinary frequency.

When conducting the study, the research team first applied a catheter to bring about cystitis using a substance known as acrolein. Next, they treated the mice using GP1a, which is a selective CB2 agonist. They also used a placebo at three separate intervals: 3.5 hrs, 22 hrs, and 30 hrs after the actual acrolein installation. Researchers then examined all mouses after 48 hours.

Based on their results, the activation of the CB2 receptors appeared to reduce inflammation, since bladder weight and swelling were reduced in the group that got cannabinoid treatment. Similarly, the activation of CB2 receptors inhibited acrolein-induced pain as well. Just like expected, cystitis greatly enhanced urinary frequency in mice. On the contrary, the activation of the CB2 receptors also appeared to reduce this effect.

Research demonstrates a relationship between bladder functioning and endocannabinoids. These research findings suggest that the results may open even more opportunities for cannabinoid use when it comes to bladder inflammation. This means that the CB2 receptor may be a possible target for helping the symptoms that come with painful inflammatory bladder disorders.

Considering that phytocannabinoids such as cannabidiol (CBD) and tetrahydrocannabinol (THC) are thought to interact with the CB2 receptors, this might suggest that cannabis might be of benefit when it comes to managing the symptoms of chronic bladder ailments.

Bottom Line

In general, CBD seems to interact with both the CB1 and the CB2 receptors throughout the body, including the receptors located in the suburothelial mechanosensory apparatus. This is the mechanism where the bladder reacts to mechanical stimuli like filling with urine. In many studies, cannabinoids, including CBG, THC, and CBD, may show promise when it comes to relieving bladder regulation issues. This is thought to be because of how CBD works with the natural cannabinoid receptors in the human body’s bladder control pathways. That means that CBD products may show promise in improving urinary incontinence conditions, without the possible adverse side effects of traditional pharmaceuticals.

While research on the effects of CBD on the bladder is still in the early stages, one interesting find was the fact that the ECS also exists in the bladder.