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CBD Effect On Teeth

Brushing twice, flossing and using mouthwash after every meal are undoubtedly imperative for taking care of your teeth.

But did you know Cannabidiol (CBD) can help prevent oral complications such as gingivitis, gum disease, or tooth loss?

CBD is the primary non-psychoactive chemical in the cannabis plant. It is known for its science-backed medicinal properties. Research suggests that beyond its exciting therapeutic benefits, CBD can also protect and improve your dental health.

CBD is an anti-inflammatory, antifungal, antibacterial, and bone stimulant substance that helps restore and strengthen oral health.

It not only prevents cavities, decay, and gum diseases, but it can also accelerate the healing process for any oral damages.

Treats and Prevents Gum Diseases

The food and drinks we enjoy daily allow sugars and starches feed bacteria in our mouth. As a result, plaque builds up quickly, and lack of proper oral hygiene results in various stages of gum diseases.

The first stage of gum disease is called gingivitis. This inflammatory condition is caused when food particles mix with spit and bacterial-forming plaque sticks to your teeth. At this stage, teeth start bleeding from tooth brushing.

Periodontitis is the advanced and dangerous stage of gum disease. Over 64 million American adults deal with periodontitis marked by loose teeth, swollen gums, shifting teeth, receding gums, and bad breath.

Plaque accumulates and hardens as aggressive tartar under the gum line. It quickly triggers an inflammatory response in the gums, which, if continues over a long period of time, forms pockets between the teeth and gums.

Bacteria, plaque, and tartar saturate those pockets. It eventually causes the death of healthy gum tissue, tooth loss, and jawbone degradation.

How CBD helps gum diseases –

CBD is a potent anti-inflammatory substance that can slow down periodontitis. It interacts with CBD2 receptors in our body and regulates inflammation. The analgesic effects of CBD can also relieve sensitive teeth.

A CBD oil or mouthwash helps bleeding gums, and vigorously swilling CBD-infused oil around the mouth tackle bacteria.

While none of this will reduce the necessity of regular dental checkups, it could still be a useful addition to your oral care routine.

Relives Toothache

Toothaches often happen because of pulpits, an infection. The pulp is a soft area that contains blood vessels and nerves. We feel cold, heat, and touch in our teeth because of pulp in their center.

Injured or infected pulp causes toothache. Pulpit often occurs because of gum diseases, tooth decay, trauma, or impaction.

How CBD helps toothache –

CBD relieves toothache in affected teeth by interacting with cannabinoid receptors. Some of these receptors are linked to our immune system and control its response on interaction with CBD.

Since our body causes inflammation for immune purposes, CBD reduces the inflammation they make, reducing the pain and swelling caused by a toothache.

Strengthens Oral Microbiome

Not all bacteria are evil. Good bacteria promote strong immune functioning and let a healthy mouth thrive.

Our tongue, gums, hard palate, and other oral surfaces host around 700 species of aerobic and anaerobic organisms. We swallow one trillion bacteria daily.

Excessive bad bacteria in mouth seed our gastrointestinal tract with imbalance, triggering systemic disease, and immune dysfunction. Nearly 45% overlap of bacteria between our mouth and colon demonstrates the link between the oral microbiome and gut.

Unfortunately, the common oral care products available on the market destroy both bad and good bacteria. Thus, regular use of fluoride toothpaste and abrasive mouthwash wipes down your oral microbiome. It leaves the mouth prone to inflammation and pain.

How CBD promotes oral microbiome –

CBD doesn’t act like fluoride toothpaste or other dental health products.

Instead of stripping away the healthy bacteria, CBD encourages the cultivation of good bacteria that support a healthier oral microbiome.

CBD and Temporomandibular Joint Dysfunction (TMJ)

May times, a toothache is associated with the temporomandibular joint, jaw, and neck muscles. The main cause of this problem is tooth grinding and jaw clenching.

The other reasons can be habitual gum chewing, trauma, or misaligned teeth. TMJ can be a very serious problem, and patients should seek immediate help.

A clinical study found that people experiencing TMJ noticed a reduction in symptoms after CBD treatment. Cannabidiol soothes inflammation that causes arthritis damage while also decreasing your pain sensitivity. Teeth clenching and grinding often result from stress and anxiety, which CBD may reduce.

Dental Anxiety – CBD Oil after Tooth Extraction

Did you know dental phobia is more common than the phobia of heights? Science and user reports suggest that taking CBD oil reduces dental anxiety.

Dental surgeon Mark Burhenne recommends CBD oil for his patients to calm the anxiety speed up the healing process after they underwent dental surgery. Burhenne says CBD is the most powerful anti-inflammatory substance generally with zero side effects.

Experts recommend 1.5 milligrams of CBD oil in capsule form for every 10 pounds of your weight the night before and the morning of your dental procedure. Children should keep it between 8-10 drops of CBD oil in spray form the morning of the dental treatment.

Good and Bad CBD

Most CBD is identified as full-spectrum CBD or CBD isolate. Full spectrum or whole plant CBD product contains CBD, while only up to 0.3 percent THC. It may also pack other cannabis substance such as CNB, CNG, and possibly THC.

On the other hand, CBD isolate products contain only CBD and no other parts of cannabis substance. CBD isolate is obtained by purifying CBD extracted from the hemp plant. It is then isolated from other cannabinoids. CBD isolate offer amplified anti-inflammatory healing benefits.

How to use CBD for Dental Health

Assuming that oral CBD consumption safe, applying CBD directly to your affected tooth and gums might be a secure and effective way for the treatment.

You can apply oral CBD sprays, oils, ointments, or tinctures on the affected area using a clean finger. Gently spread on your tooth and gums. You can try CBD toothpowder infused with CBD oil and concentrated with clay that naturally destroys bad bacteria without killing good bacteria.

You can also apply a crushed cannabidiol pill on the affected area. A teabag with high-CBD dried flowers might also work.

While CBD application doesn’t entirely replace regular dental check-ups, it could be a useful addition to your oral care routine.

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Brushing twice, flossing and using mouthwash after every meal are undoubtedly imperative for taking care of your teeth.

CBD in Dentistry – Can Cannabis Cure Cavities?

Publié le 28 Avr 2015

Currently, the majority of research in medical marijuana focuses exclusively on analyzing its effectiveness in treating various ailments of the human body. Dental marijuana research has not been extensively investigated, and hallmark features critical to heal dentition with this medicinal drug are vastly unknown. This systematic research review aims to 1) identify various molecular caries (cavities) mechanisms and 2) determine future prospects of cannaboid research in dentistry.

Dental caries (rottenness) has been a somewhat intangible quality to measure, and attempts at eliminating it from dentistry have generally failed due to its intrinsic complexity. Dentistry pervades many aspects of our history and culture. During the mid 16 th century of the Renaissance period, dental patients sought to use herbs such as rosemary charcoal to not only maintain proper oral hygiene, but to alleviate painful tooth decay that many can empathize with to this day. Sage shrubs were also used to become an effective “teeth-whitening strip”, often cooked tediously and compounded to activate the “whitening” ingredients. Dentistry has evolved our entire life for hundreds of centuries, yet modern studies of dentistry have neglected to enhance or advance the same natural remedies used centuries ago to date. To this end, with the emerging knowledge of medicinal marijuana benefits, more specifically cannabidiol active ingredients (CBD), there has been a profound transition to identify the benefits of this drug at a clinical level. Many paste products focusing on hemp and marijuana plant driven ingredients have marketed this plant in hopes of penetrating the 12 billion dollar market share of the toothpaste industry. Yet the influences of various commercially available toothpaste products are fairly similar, with fluoride as their primary active ingredient in varying quantities. Generally, these pastes contain limited ingredients; resulting in limited data collection to determine the best paste that would effectively combat tooth decay. Furthermore, utilizing a wide range of focus group patients to evaluate caries, or recruiting study participants who are willing to use placebo paste, or ineffective paste in an effort to prevent caries, is often a violation of IRB research protocol. These two factors can limit the breadth and scope of most dental studies, as it is often difficult to control the basic parameters of the oral cavity unique to each participant.

Caries at Molecular Level

There is much dental literature that shows molecularly identified causes of dental caries (cavities). Various pathways that regulate protein metabolism, glucose regulation, and transaminase reactions have been shown clinically to cause caries. These unique pathways allow for colonization of biofilms in the oral mucosa and produce a harmful acidic environment that causes demineralization of dentition, and ultimately infection and caries. Traditionally, dental decay can more or less be detected with radiographs and clinical examination of the dentition. Various descriptions such as E1 (Enamel), E2, D1 (Dentin), D2, D3 lesions are often diagnosed by the dentist and assessed for treatment.

Of note, bacteria such as Streptococcus mutans and Lactobacillus are two of the most common bacterial organisms that are subject to scrutiny due to their prevalence in causing caries. 1 Furthermore, pH and availability of glycoproteins have the most salient influence on the composition and biochemical activities of biofilms. In other words, the more basic or alkaline the oral cavity, the less probability that bacteria will colonize and cause decay. Research in prevention and treatment of dental caries at the molecular level has become seemingly more important to the medical arena in recent years. 1, 2

STAMP tool

A novel method that is currently at a pilot stage is the STAMP tool, which is an acronym for “specifically targeted antimicrobial peptides.”

“The toothy tool comes from scientists including Wenyuan Shi, PhD, of the School of Dentistry at the University of California, Los Angeles (UCLA). They call their tool “STAMP” (specifically targeted antimicrobial peptides). Basically, STAMP is a tiny protein that knocks out a cavity-causing bacterium without harming healthy bacteria,” Dr. Shi explains in a news release from the National Institute of Dental and Craniofacial Research, one of the study’s sponsors.

“The good bacteria are mixed in with the bad ones,” Shi says.

Current treatments “simply clear everything away,” Shi says. “That can be a problem because we have data to show that the pathogens [the bad bacteria] grow back first.” More on this can be found here

Signal Recognition Particle Pathway

Much like other organisms that use various protein pathways to survive, one of the most prevalent mechanisms is the use of a signal recognition particle pathway (SRP) to deliver a protective protein layer to cellular membrane receptors in harsh acidic environmental conditions. 1, 7 Research has shown that a lack of infusion of protein to the membrane will yield a weakened cellular membrane that is prone to attack by bacterial defense mechanism in saliva such as beta-defensin-.1 1 S. mutans uses this pathway for growth by protein recognition and delivery to membrane. Recent research however has shown thatS.mutans can use an alternative form of this pathway for growth and adherence to tissue. 3 Two other molecular genes called YidC1 and YidC2 has been suggested to act as an alternate route for protein delivery to the membrane in the absence of the SRP pathway. 3

Aspartate Amino Transferase

Delivery of protein by the SRP pathway (or other alternative pathways) has lead researchers to investigatehow the organism can metabolize protein within the cell. Investigators have identified much bacterial protein activity on the pellicle layer of teeth, which has been a causative agent in caries. Two of the most ubiquitous protein processes that many bacterial organisms utilize is the alanine amino transferase (ALT), and the aspartate amino transferase (AST) pathways. 7 Both amino transferases catalyzes the transfer of an amino group from alanine or aspartate to α-ketoglutarate, which in turn produce either pyruvate and glutamate or oxalacetate and glutamate respectfully. 3 This process allows bacterial organisms to use various glycoprotiens (such as proline) within the enamel surface for bacterial adhesion and growth. 3 Studies have shown that the AST and ALT pathways significantly increase with patients suffering from periodontal disease and high-risk caries. This implies a strong correlation with ALT and AST pathways in dental caries, though much analysis is required for recognition. 3

Glucose Transport

Glucose transport to various parts of cellular tissue is a common pathway for many organisms to function properly. 6, 7 Many bacteria use a specific glucose transport system to regulate their metabolism and allow for the survival of cohort species. Research has investigated that oral bacteria (S. mutan, S sanguis) generally use a Phosphoenolpyruvate (PEP-dependent) mechanism for glucose transport. 4, 5 Through various target receptors and secondary messengers, the main mechanism of action allows for phosphorylation of a glucose molecule at carbon 6, which has been shown to cause resistance to fluoride. 5, 6 Research has also shown that this pathway has inhibitory effects on glycolysis by blocking enolase activity, thus allowing the bacteria to prevent excessive uptake of glucose while in the anabolic process of growth. 4, 5

These pathways are just a select few that have given dental clinicians artillery of information to combat dental decay. The focus on the mechanism of action (protein metabolism, glucose regulation, and transaminase reactions) of oral bacteria can be one of the most promising areas of knowledge to prevent dental caries. There may be a growing need for many clinicians is to look further into medical marijuana effects in dental caries, more specifically enabling biofilm degradation as well as preventive treatment of caries with antibacterial properties of CBD. The technology and science behind this type of dental research has been documented for decades, but lacks the necessary focus required to determine CBD effects in dentistry. I believe as the general public becomes more aware of the beneficial ingredients of medical marijuana in quality treatment and care, it will soon find its way to become a multi-billion dollar industry in dentistry.

Cannabidiol (CBD) and Dentistry
With the emerging indications of the effectiveness of CBD in medical therapy, dentists should begin to seriously consider the vast implications of medical marijuana as part of their dental therapy regiment. And while ignoring the stigma and taboo that marijuana often faces in society, progressive clinicians and dentists should recognize CBD as a powerful treatment modality. A simple google search on CBD and its benefits is readily available and such benefits are generally recognized by clinicians. Below is a chart adopted from marijuana.com that gives insight to the powerful affects of CBG, CBGA and CBCA. Note that antibacterial and anti-inflammatory ingredients are one of the most salient qualities needed in dentistry.

Cannabis Products

Cannabis products created by companies such as Axim Biotech are paving the way to fight dental decay with CBD. Cannabigerol, the active ingredient in Axim’s dental products, has shown to have anti-inflammatory properties, which are ideal in periodontal disease and gum sensitivity. This is a tantamount milestone in the world of dentistry. Much of the anti-inflammatory agents used currently are chlorohexidene irrigation rinses, which often tastes bitter and can leave a slight tooth discoloration with continual use. Axim is also engaged in creating a type of Canagum, which can basically allow for cannabinoids to be secreted into saliva, thus preventing biofilm attachment.

Another company, Cannaderm has a hemp infused toothpaste that is readily able to re-mineralize enamel and decrease tooth sensitivity.

The future of dentistry

Pilot clinical trials with CBD at a molecular level should be evaluated with the most common types of bacteria that cause tooth decay. (S. mutans, and Lactobacillis) Even a simple research experiment, where injections of CBD strains are assessed to determine colony forming units on a blood agar dish with S. mutans and Lactobacillis would be a promising attempt to develop an advance in this area. Dental research with CBD is far from over, but a handful of companies have demonstrated its potential value. In future work, clincians should seek to perform large-scale comparisons between CBD toothpaste vs regular toothpaste, and corresponding dental composite fillings treated with CBD infused composite glass ionomer products. The possibilities are truly endless.

This collective approach will allow us to combat tooth decay both comprehensively and vigorously. Future studies will emulate ideas conveyed in this paper and may realistically require more than 100 clinical trials in order to achieve profound evidence based clinical power, nevertheless, it is something that should be sought and meticulously scrutinized by dental clinical research.

CBD in Dentistry – Can Cannabis Cure Cavities?