In older people, MCTs are used to increase muscle mass and strength. They are also used for a rare disease called Waldmann disease. MCTs are sometimes used as a source of fat in total parenteral nutrition (TPN). In TPN, all food is delivered intravenously (by IV). This type of feeding is necessary in people whose gastrointestinal (GI) tract is no longer working.
Intravenous MCTs are also given to prevent muscle breakdown in critically ill patients. MCTs are a fat source for patients who cannot tolerate other types of fats. Researchers also think that these fats produce chemicals in the body that might help fight Alzheimer's disease. These fats might also result in weight loss because the body uses them in a different way to other types of fats. Preventing muscle breakdown in critically ill patients, when given intravenously (by IV). MCTs can provide calories in critically ill patients, but don't seem to offer any advantages over normal dietary fats (long chain triglycerides). Some research shows that taking MCTs by mouth can reduce some types of seizures such as akinetic, clonic, and petit mal. Following a low-fat, high-protein diet and supplementing with MCTs seems to reduce symptoms in patients with Waldmann disease. Some research shows that taking MCTs does not seem to be any more effective than taking multivitamins and minerals alone for prevention of weight loss associated with AIDS.
Most research shows that taking MCTs does not improve exercise performance. However, MCTs might help athletes exercise longer when taken with carbohydrates. Early research shows that taking MCTs along with leucine and vitamin D increases the amount of muscle and improves strength in older people who have lost a lot of muscle mass. There is interest in using MCTs to treat Alzheimer's disease because MCTs might provide extra energy to the brain and might also protect the brain against damage from beta-amyloid protein plaques. These plaques are the structures that form in Alzheimer's disease and cause symptoms. Some research shows that a specific MCT product (AC-1202) does not significantly improve learning, memory and information processing (cognitive thinking) in people with mild to moderate Alzheimer's disease, except in people with a particular genetic make-up (change in the APOE4 gene). In the people with the APEO4 gene change, a single dose of the MCT product seems to improve cognitive thinking skills. Taking MCTs by mouth or intravenously (by IV) might prevent malnutrition and a weakened ability to fight infection in children and adults with chylothorax. High levels of fats in the blood (hypertriglyceridemia). Consuming an oil containing both medium- and long-chain fatty acids reduces levels of triglycerides in the blood in overweight patients. However, it might not be effective in people with high levels of these fats who are very overweight (obese) or normal-weight. Research shows that taking MCTs can decrease body weight, body fat, and waist and hip circumference by a small amount. At least 4 weeks of use is likely needed to see any benefit. Men, people of Asian descent, and people with the highest amount of body fat before treatment seem to benefit the most. However, for most people any benefit is only slight and might not be clinically meaningful. More evidence is needed to rate the effectiveness of MCTs for these uses. Special Precautions & Warnings: Pregnancy and breast-feeding : Not enough is known about the use of MCTs during pregnancy and breast-feeding. Children : MCTs are POSSIBLY SAFE for most children when taken by mouth. Diabetes : MCTs can cause certain chemicals called ketones to build up in the body. Liver problems : Because MCTs are processed primarily by the liver, they can cause serious problems in people with liver disease. Do not use MCTs if you have cirrhosis or other liver problems. We currently have no information for MEDIUM CHAIN TRIGLYCERIDES (MCTs) Interactions. The following doses have been studied in scientific research: BY IV : For preventing muscle breakdown in critically ill patients : As a fat source for people who receive all their food intravenously (by IV): a fat mixture containing 50% MCTs and 50% long chain triglycerides (usual dietary fats) is commonly used in total parenteral nutrition (TPN) formulas. BY MOUTH : For improving seizure control : MCT oil is used as 60% of the calories eaten. Medium-Chain Triglycerides in Combination with Leucine and Vitamin D Increase Muscle Strength and Function in Frail Elderly Adults in a Randomized Controlled Trial.
Parenteral nutrition in the critically ill: use of a medium chain triglyceride emulsion. The diverse nature of saturated fats and the case of medium-chain triglycerides: how one recommendation may not fit all. Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. A cross-over study of the effect of a single oral feeding of medium chain triglyceride oil vs canola oil on post-ingestion plasma triglyceride levels in healthy men.
Chylous-fluid triglycerides and lipoproteins in a patient with chylothorax put on a diet of butter or medium-chain triglyceride [proceeedings].