Nephrotoxicity is a common adverse effect of the potent chemotherapy agent cisplatin, thus the oxidative and nitrosative stress limits its clinical use. Treatment of mice with cannabidiol attenuated the cellular stress, the inflammation, and cell death in the kidney caused by cisplatin, greatly improving the renal function. The results of this study suggest that CBD may act against cisplatin-induced nephrotoxicity. And of course that CBD deserves more research in this area.
Cannabis has very few side effects on our organs and there is no risk of a cannabinoid overdose damaging our kidneys, yet patients with kidney diseases should be particularly careful in starting alternative therapeutic regimes, and they should discuss all the supplements they take with an informed healthcare specialist. Improvements in kidney disease symptoms with the assumption of CBD and/or THC might be real and should be clinically considered, as long as these or other supplements don’t interact with prescribed drugs, and remembering that vaporization or edibles eliminate the harms related to smoking. Cannabidiol (CBD) acts as a natural alternative or supplement to typical treatments for kidney disease. Learn how CBD works with your body to provide relief. Also known as CRF or chronic kidney disease, chronic renal failure happens when your kidney starts to lose function. We need our kidneys to filter excess waste and get rid of it through urine. When the kidney stops working as intended, this waste builds up in your system. The symptoms of CRF develop at the same pace as the kidney damage’s progress. You can experience fluid buildup in your ankles, feet, heart or lungs. CRF can also cause eating issues such as nausea and appetite loss.
Some patients feel tired all the time or have difficulty thinking. A diseased kidney can impact all parts of the body because of the lack of the organ’s critical functions. In the early stages of the disorder, you may get muscle cramps that feel painful. During the late stages, you can have pain in your back or abdomen. Natural pain relievers like CBD can relieve these symptoms without causing further damage to your kidney. Cannabinoids such as CBD heal our bodies by working with our natural systems. We all have an endocannabinoid system that creates and uses these compounds. When a cannabinoid activates one of the system’s receptors, it regulates bodily functions like sensation and mood. The body can also produce endocannabinoids as a response to certain kinds of stimuli or damage. When CRF causes pain, the body releases the endocannabinoid anandamide as a defense mechanism. Damaged and inflamed tissue creates extra cannabinoids to regulate your pain response. Anandamide also has a role to play in mood, digestion and other functions. Taking CBD lets you tap into your body’s innate healing powers to make your CRF symptoms more comfortable. It relieves pain so you can focus on other aspects of your recovery. CBD has a unique interaction with your endocannabinoid system. Most cannabinoids, including tetrahydrocannabinol (THC), attach to your cannabinoid receptors. The receptors then use the compound to send signals to your body. When you use CBD, it enhances the function of your endocannabinoid system. It blocks FAAH, a fatty acid that breaks down anandamide to help you keep more anandamide in your body. As a result, your kidney tissue can create more anandamide when it sends pain signals. The anandamide binds to your CB1 receptors to control your pain response. You can find these CB1 receptors throughout your body, including organ tissue. Some researchers think CB1 receptors could even act as a necessary part of your system’s pain management. Taking CBD can also manipulate your endocannabinoid system to relieve additional symptoms of CRF.
It impacts your sleep-wake cycle, so it helps you get to sleep at night. When CRF causes elevated blood pressure, CBD lowers it to lessen the stress on your heart. Anandamide is just one of many cannabinoids found in marijuana and your body. Combining CBD treatment with cannabinoids such as THC can improve your symptom relief.
The entourage effect happens when you take multiple kinds of cannabinoids.