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How to Reset Your Cannabis Tolerance

Feel like cannabis isn’t working for you the way it used to? You might be dealing with a high tolerance.

Tolerance refers to your body’s process of getting used to cannabis, which can result in weaker effects.

In other words, you need to ingest more to get the same effects you once did. This can be particularly problematic if you’re using cannabis for medical reasons.

Fortunately, it’s pretty easy to reset your tolerance.

Cannabis tolerance develops when you use it regularly.

Tetrahydrocannabinol (THC) is the psychoactive compound in cannabis. It works by affecting the cannabinoid type 1 (CB1) receptors in the brain.

If you ingest THC often, your CB1 receptors are reduced over time. This means the same amount of THC won’t affect the CB1 receptors in the same way, resulting in reduced effects.

There’s no strict timeline for how tolerance develops. It depends on a range of factors, including:

  • how often you use cannabis
  • how strong the cannabis is
  • your personal biology

One of the most common ways to lower your cannabis tolerance is to take a break from using cannabis. These are often called “T breaks.”

Research shows that, while THC can deplete your CB1 receptors, they can recover over time and return to their previous levels.

The length of your T break is up to you. There’s no solid data on exactly how long it takes for CB1 receptors to recover, so you’ll have to experiment a bit.

Some people find that a few days does the trick. Most online forums advise that 2 weeks is the ideal time frame.

If you’re using cannabis for medical reasons, taking a T break might not be feasible. There are a few other strategies you can try.

Use cannabis products with a higher CBD-to-THC ratio

Cannabidiol (CBD) is another chemical found in cannabis. It doesn’t seem to lead to depletion of CB1 receptors, meaning it doesn’t cause you to develop tolerance the way THC does.

CBD won’t give you a “high,” but it does seem to have several potential health benefits, such as reducing pain and inflammation.

At many dispensaries, you can find products ranging from a 1-to-1 ratio to as high as 16-to-1.

Tightly control your doses

The less cannabis you use, the less likely you are to develop a tolerance. Use the minimum you need to feel comfortable, and try not to overindulge.

Use cannabis less often

If possible, use cannabis less frequently. This can help to both reset your tolerance and prevent it from coming back again in the future.

Many people who have developed a high tolerance do go through cannabis withdrawal when taking a T break or using less cannabis than usual.

Cannabis withdrawal isn’t necessarily as intense as withdrawal from alcohol or other substances, but it can still be quite uncomfortable.

You might experience:

  • mood swings
  • fatigue
  • headaches
  • cognitive impairment
  • diminished appetite
  • stomach problems, including nausea
  • insomnia
  • intense, vivid dreams

To help with these symptoms, make sure to get plenty of hydration and rest. You can also try using over-the-counter medications to deal with headaches and nausea.

Exercise and fresh air can help you feel alert and reduce any slumps in your mood.

The withdrawal symptoms might make it tempting to continue using cannabis. To keep yourself accountable, tell your loved ones that you’re taking a break.

While the symptoms are uncomfortable, the good news is that cannabis withdrawal symptoms usually only last for 72 hours.

Once you’ve reset your tolerance, keep the following in mind to keep your tolerance in check moving forward:

  • Use lower-THC products. Since it’s THC that leads to the depletion of your CB1 receptors, it’s wise to opt for products that are a bit lower in THC.
  • Don’t use cannabis too often. The more you use it, the higher your tolerance will be, so try to only use it occasionally or as needed.
  • Use a lower dosage. Try consuming less cannabis at a time, and try to wait a bit longer before re-dosing.
  • Use CBD instead. You may want to consider giving CBD-only products a try if you’re looking to reap the potential health benefits of cannabis. However, THC does have some benefits that CBD doesn’t seem to have, so this switch isn’t viable for everyone.

Keep in mind that tolerance might be unavoidable for some folks. If you find that you’re prone to developing a high tolerance, consider coming up with a plan to take regular T breaks as needed.

It’s pretty normal to develop a tolerance to cannabis if you use it often. In most cases, taking a T break for a week or two will reset your tolerance.

If that’s not an option, consider switching to products that are lower in THC or reducing your cannabis consumption.

Keep in mind that cannabis tolerance can sometimes be a sign of cannabis use disorder. If you’re concerned about your cannabis use, you have options:

  • Have an open and honest conversation with your healthcare provider.
  • Call SAMHSA’s national helpline at 800-662-HELP (4357), or use their online treatment locater.
  • Find a support group through the Support Group Project.

Sian Ferguson is a freelance writer and editor based in Cape Town, South Africa. Her writing covers issues relating to social justice, cannabis, and health. You can reach out to her on Twitter.

If you've been consuming weed for a while, you've probably developed a high tolerance along the way. Here's how to reset it and keep it from happening again.

Can CBD Counteract the Effects of THC?

CBD is considered to be anti-psychotic, and therefore can mediate the psychoactive effects of THC. But to what degree can this be proven in a lab, and to what extent can recreational users exploit this quality of CBD? Scientific and anecdotal evidence point to the conclusion that CBD can counteract the effects of THC, perhaps via the entourage effect.

CBD and THC are two of the most well known and well researched cannabinoids. For the last ten years, the media has popularized their various properties, medicinal and otherwise. There is increasing public awareness that continues to drive the cause of cannabinoids in medicine.

The question is commonly presented: can CBD counteract the effects of THC? To answer the question: yes, CBD can counter the effects triggered by THC. The claim has been proven both on a clinical level, via studies meant to explore the future possibilities for pharmaceutical, cannabis-based drugs, and via numerous anecdotal reports from recreational users.

CBD and THC levels vary among different cannabis strains. Varieties containing high levels of either cannabinoid are advertised as such, so that medical and recreational users have the freedom to personalise their experience.

From a recreational standpoint, CBD is not conventionally sought after. THC, on the other hand, is psychoactive and therefore has a recreational application. It is usually the THC level that defines the overall “potency” of the strain, although this does depend on what the strain is being used for.

Cannabis varieties with high levels of CBD are mostly popular among medicinal cannabis users, as well as mild recreational users looking to wind down without necessarily finding themselves in a potentially dysfunctional haze. This is because CBD is non-psychoactive and is abundant in therapeutic effects.

CBD to counter THC in medicine

Because of the illegal status of cannabis that remains in many countries, the use of cannabinoids for medicinal purposes is not exactly as democratized as it should be. THC, despite its countless potential advantages (pain management, appetite stimulant, antiemetic, intraocular pressure relief, etc.), is still the object of taboo, solely because of its psychoactive properties. CBD on the other hand, while a poor choice for recreational users, is very much focused on in medicine, in order to create treatments involving minimal side effects.

Most of THC-induced effects result from its partial agonist activity on receptors CB1 and CB2, respectively present mainly in the central nervous system and in the immune system. Its psychoactive properties, for instance, have to do with the former. CBD’s affinity for cannabinoid receptors is much weaker than THC, although it impacts the endocannabinoid system in other ways. However, CBD acts as a partial CB1 antagonist, and as a weak inverse CB2 agonist.

In this study published in Front Psychology, the question of CBDs countereffect on psychoactive THC was questioned. It is questioned in the context of countering the “permanent” and “adverse” effects of THC such as paranoia, anxiety and memory impairment. This is particularly pertinent in the case of medicinal cannabis users who may want the medicinal benefits of cannabis but who may experience negative side effects from THC. In any case, the analysis shows that CBD may be neuroprotective and therefore, to a certain degree, counteract negative side effects of THC.

In fact, CBD’s interaction with THC is an example of the “entourage effect”, whereby all cannabinoids and terpenoids present in a specimen of cannabis contribute to the overall effect in a collective manner. CBD and THC can coexist as a viable treatment option, even for those who are sensitive to the effects of THC and are prone to the negative side effects. In another example, CBD slows the breakdown of THC in the liver, allowing for a longer efficiency of its therapeutic attributes.

There is much work to be done in terms of determining the exact details of how CBD interacts with CB1 and CB2 receptors, thus impacting the effects produced by THC. When CBD is taken out of context, i.e., in a single cannabinoid medicine, it is unclear how it interacts with THC.

The entourage effect is something that generally refers to all the cannabinoids present in a single specimen of cannabis. Modern science is, as yet, unsure how the entourage effect translates into combining single cannabinoids that have already been isolated from the plant.

For example, in this study, researchers investigated the effects of orally consumed CBD on the effects of smoked THC. When oral CBD was administered, researchers observed no significant effect on any of the outcomes measured. This suggests that CBD’s effects on THC are due to individual differences in plasma drug levels.

Furthermore, modern medicine confirms why THC is psychoactive, namely because THC acts on CB1 receptors (partial agonist) in the central nervous system). CBD, however, is a partial antagonist of CB1 receptors. This may be why it is very difficult to recreate the entourage effect in a laboratory.

CBD is considered to be anti-psychotic and neuroprotective. This has implications for the application of CBD in certain mental illnesses such as bipolar, schizophrenia, dementia etc. However, it is not understood how these characteristics mediate the effects of THC outside of the entourage effect, and therefore requires further research.

Recreational cannabis users and CBD

Different cannabis strains are advertised as having different qualities: “couch-lock”, “energetic”, “powerhouses” and “relaxing”. This is, in large part, due to the concentration of different cannabinoids, terpenes and flavonoids.

The question of whether CBD can counteract the effects of THC has piqued scientific curiosity for some time now. However, designing such a study is extremely difficult because it requires isolating cannabinoids and then administering them together.

This is necessary because otherwise researchers would not know how much of each cannabinoid is administered. At the same time, this kind of study takes cannabinoids out of context and therefore removes the entourage effect, which may be the whole mechanism by which CBD mediates THC effects.

As a result, anecdotal stories and recreational users remain some of the best sources of information regarding how CBD mediates the effects of THC.

It has become increasingly commonplace for recreational users to resort to CBD in the event of a ‘white-out’ (an unpleasant but harmless cannabis ‘overdose’). Recreational users report that this works, which would create an unusual situation where CBD could be used by recreational cannabis users.

But in the spirit of making the cannabis experience an inclusive one, it is important – even to those who don’t need it – to wonder in which contexts recreational CBD could in fact be beneficial. It’s an important consequence of this question, alongside whether CBD can help those using medicinal THC to overcome the unwanted side effects.

Don’t forget to tell us about your own experience with THC & CBD in the comments section!

CBD can counter some of the effects triggered by THC. Why is this useful for both recreational and medicinal users? Read more here.