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The group of researchers did an experiment with male participants aged between 18 and 35. The study focused on CB1 receptors, for which THC has a considerable binding affinity. Besides proving what we’ve already suspected, they also found something very interesting: regular (but moderate) daily cannabis users had 20% less CB1 receptors than the participants from the control group who did not use cannabis. (1) And how long does it take to regenerate CB1 receptors? Well, believe it or not, it takes just two days to four weeks of abstinence to regenerate almost all of your CB receptors .

What was really surprising in this study is that no matter how much cannabis they consumed, after just a two-day tolerance break, test subjects started growing their CB1 receptors back. (1) This study was criticized for not including female participants since THC supposedly affects women differently, but we can all agree that this is a good starting point for further research. Besides sex, there are many other factors that affect how people build up the tolerance to cannabis. Both the consumption method and the amount consumed play a major role in developing tolerance, as do some physiological factors like the body mass index for example. The truth is that the human body actually becomes tolerant of cannabis very quickly. It takes just one week of frequent cannabis use to build enough tolerance to start needing an increased amount for the same effects. The situation gets even worse when you realize that using high THC products leads to developing tolerance faster. (2) Interestingly enough, it seems that CB receptors in certain parts of the human body downregulate faster than others. Colon, for example, seems to be resistant to cannabis tolerance. There are a few things that you can do to avoid building up the tolerance to cannabis.

First off, know that this primarily happens with heavy daily consumers. So, the first thing you can do is to reduce the frequency and volume of cannabis consumption to a moderate level. The trick to this is to use an approach called microdosing, which relies on using the smallest amounts of cannabis you need to achieve the desired effects. This approach is particularly useful for medical users who need to stay medicated throughout the day. To do this properly, take just a few puffs at a time. By following this routine you will not be completely resistant to developing tolerance, but you will not build it up as quickly as if you were to smoke an ounce a day all by yourself. Dustin Sulak who treated over 18,000 patients with medical cannabis and put his microdosing strategies in a free eBook. Download the blueprint to the most effective cannabis dosage regimen. When you reach the point where almost no amount of cannabis can get you high enough, it’s time to take a break and rebuild your receptors. The easiest way to do so is to abstain from cannabis for 1-2 weeks . The more you abstain the better your results will be, but a week should be the absolute minimum. Taking a tolerance break is actually not that difficult, as you’ll be motivated by the fact that your receptors will recover fully. Best of all, the first joint you light up after that week will feel like you’re getting high for the first time. Although it can be tough to stay away from weed, especially when the anxiety kicks in, give it your best and try to stay on the right path. Here are a few tricks that I use when I’m taking tolerance breaks. Keep yourself busy, stay active and try to work out. Go back to some of your old hobbies (if you had them) and try to eat healthier. Pipes, bongs and rolling papers should be out of your sight during the break. No, really—don’t stash it for when the break is over. It’s always tempting when you know you have some in the bottom drawer. Surround yourself with people you love, attend some social events. All in all, do the things that really make you happy (except smoking weed, yikes). How to bring down cannabis tolerance without taking a break? For medical users who need cannabis just to get through the day, taking a tolerance break is not possible. Anxiety, sleepless nights and mood changes are just a few side effects of taking a weed tolerance break. However, there are a few methods to lower your tolerance to some extent without quitting weed completely. Although us humans are addicted to routines, switching it all up from time to time can be very beneficial.

And I suppose you already have a routine when it comes to smoking weed. However, your body will eventually get used to all those cannabinoids at the same exact time and that will aid in boosting your tolerance up. By introducing a few changes in your daily routine, you’re shocking your body and you’re not letting it get used to cannabis. To start, try consuming weed at different times than usual. That can actually trick your brain into thinking you are doing something new. When you get stoned in the morning you have to smoke all day to maintain the same level of high. And that’s not good if you are trying to lower your tolerance. So, we go back to the first advice: try smoking later in the evening to shock your body a little bit. So if you’ve already reached a point where you need more and more to get high, you might want to go down the opposite route and start smoking less. I talked about microdosing earlier in this article, but if that doesn’t do the trick for you, cut the amount of weed you smoke in half.

Also, try cutting down the number of daily smoke sessions. This is a good starting point and the easiest way to cut the amount of weed you are smoking without having to quit completely.

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