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Compounding the issue, stopping antidepressant medications can often result in withdrawal symptoms. CBD is showing promise as an effective alternative option for those dealing with depression. In one animal study, CBD was found to have antidepressant-like effects in mice by helping to activate the 5-HT1A receptor, which is normally activated by the feel-good neurotransmitter serotonin. In another study, CBD was found to increase the amount of the “bliss molecule,” anandamide, in the brain. Anandamide is the neurotransmitter most commonly associated with feelings of joy and happiness.

While long-term use of antidepressants can lead to weight gain, loss of sexual function, emotional numbness, withdrawal, and even addiction, CBD oil has not been shown to produce any of these negative side effects. Another potential long-term use case for CBD oil is in the treatment of chronic pain. Suffers of chronic pain are frequently prescribed medications with significant side effects, many of which are habit-forming. Those that wish to come off pain medications are often faced with debilitating withdrawal symptoms on top of the pain they’re already dealing with. CBD oil, in comparison, is beginning to look like a great alternative treatment for pain. In a comprehensive review of clinical trials examining CBD’s effect on difficult-to-treat pain, it was concluded that CBD offers a promising alternative or complement to current treatments for pain management. And given the possibility for reverse tolerance, CBD oil dosages may be tapered down over time, mitigating any potential risks of long-term use. Since you’re unlikely to build a strong tolerance to CBD oil, and may in fact be dealing with reverse tolerance the more you use, how can you continue to get the most from your CBD product? In order to properly understand the effects CBD is having on you, it is recommended that you keep a daily log.

Each time you take CBD oil, write down the amount you have taken and when you have taken it. Write down any effects you experience, including any changes you notice in your physical body or mental processes. Writing these developments down will be crucial to finding your ideal dosage and deciding if CBD oil right for you in the long-run. When it comes to choosing a CBD product, don’t be afraid to experiment with different strains, brands, and delivery formats (e.g. You may have to try a few different products before you find the one that works best for you. Remember to note how different products affect you—maybe a CBD vape is great for when you’re feeling anxious, but CBD drops are best for relieving pain. Finding the right CBD product(s) for your needs is a personal and exciting journey! One of the best ways to see continual CBD benefits is to mix up your CBD oil delivery formats. In fact, you may find it most effective to use a combination of products. A CBD oil tincture or capsule might be ideal for daily use, while a CBD flower or CBD vape pen are best for on-the-spot relief. While CBD oil is generally safe, there are some possible drug interactions that should be carefully monitored. If your doctor approves your CBD use, and you’re logging your experiences, you both can quickly narrow down the reasons for any negative effects. You should always follow the dosage recommendation included with your CBD oil product. If you’re looking for a more personal assessment, you might also consider speaking with a naturopathic doctor who can give you a specific dosing recommendation for your condition, age, weight, and experience with CBD. To take some of the guesswork out of figuring out the right CBD oil dosage, we at CBD Oil Review have come up with a general recommendation, having tested and reviewed hundreds of CBD oil products: The CBD Oil Review Serving Standard is 25mg of CBD, taken twice daily. If the desired effect is not reached at this dosage, we recommend slowly increasing your dose by 25mg every 3 to 4 weeks. Once you’ve found an effective dose that works for you, you probably won’t need to increase it. Because of reverse tolerance, you may even find that with repeated use you can actually decrease the amount of CBD you take over time. If you enjoyed this read, you may also like: Can you build a tolerance to CBD? Tolerance is an all-too-familiar concept for millions of people, as the body is very good at adapting to different substances and potentially lowering their effectiveness over time. Consider something like CBD, a supplement that is consumed daily, and it’s easy to see why many are quick to ask, "Will I build a tolerance to CBD?". Building a tolerance to any substance is not a new or strange concept—many of us even experience it in our daily lives. Take something as familiar as tea or coffee; when you first started drinking either, the boost in energy and focus made work deadlines a breeze.

Now, however, one cup has been replaced by several, with effects being significantly less profound. Given how frequently CBD is consumed, it makes sense to assume that the body will react in the same way it does with substances like tea, coffee, or sugar. Factor in the various different ways that CBD can be taken (edibles, tinctures, oils, capsules, and topicals), and it is a perfectly valid concern. However, before we can answer whether the body builds a tolerance to the effects of CBD, we first need to explore how tolerance works. Tolerance is split into three major categories: cellular, metabolic, and behavioural. Cellular tolerance implies that cells become less responsive to a compound, hence why more coffee is needed to stimulate our bodies in the example above. Metabolic tolerance, on the other hand, is where less of a substance reaches the target area, while behavioural tolerance is where we become psychologically attuned to the effects of a substance.

Interestingly, tolerance doesn't have to fall into one of the three predefined camps outlined above, and can manifest as a combination of mechanisms depending on how a particular substance interacts with the body. It is also essential to consider that the rate at which we become tolerant to a substance will vary significantly from person to person. Every one of us is unique in our genetic structure, and as such, our physiology differs too.


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