This leads to a lot of wear and tear on the joints, and thus Joe uses glucosamine & chondroitin. He first mentioned it in a 2009 post on MMA underground: Then in his 2011 supplement cupboard video, he shows that he’s using 365s Glucosamine Chondroitin & MSM. This product isn’t always well stocked, so a similar alternative is Thorne.
Products Joe Takes Occasionally/Is Experimenting With. Resveratrol & NMN (Nicotinamide Mononucleotide) On podcast episode #1234 Joe had a Harvard scientist called David Sinclair on. David shared the longevity supplements he takes, including: Resveratrol – 1g/daily (morning with yogurt) Nicotinamide Mononucleotide (NMN) – 1g/daily (in capsules, swallowed with water) During the podcast Joe creates a list of these supplements to go shopping for later. Then on episode #1269 Joe confirms he has started taking resveratrol every morning, along with NMN which he says gives him a lot of energy and makes him feel great. What do Resveratrol & NMN do in relation to living longer? David describes resveratrol and NMN as critical for the function of the sirtuin genes, genes which help us live longer. He describes resveratrol as the “accelerator pedal” for the sirtuin genes (increasing their activation), and NMN as the fuel. The reason that resveratrol won’t work effectively without NMN (the “fuel”), is that sirtuin activation requires youthful NAD levels, but NAD levels decline with age, and by 50 years old, we have about half the level of NAD we had in our 20s (NAD being a molecule that is essential to energy production in our cells).
So in effect, you take resveratrol to increase activation of the sirtuin genes, and NMN to ensure the sirtuins have enough energy to work properly. It’s worth noting that restoring NAD levels has other helpful benefits too. The complexity with these 2 supplements is that David Sinclair (who recommended them), uses product he had leftover from lab experiments – and Joe hasn’t shared explicitly which brand he uses (and no doubt brand matters, given that supplement manufacturers are unregulated). I dug into the subject in detail in the David Sinclair post, so refer to that for more details, but below is shorter version. Research published by David’s old company Sirtris (sold to GSK for $720m) found that micronized resveratrol had greater bioavailability than its regular, non-micronized counterpart, specifically up to 3.6x greater when measured in the blood. Searching micronized resveratrol on Amazon narrows down the results down to a few; including MegaResveratrol. However, I noticed something on the page for the Rich Roll interview with David Sinclair. This was interesting because during the interview Rich asks David where to get the supplements he takes, and David told him they’d talk about it after the podcast. Maybe RevGenetics was a brand that David mentioned post interview (possible), or perhaps it was just a brand Rich “plucked” from a Google search. That said, I looked into RevGenetics a little more, and they certainly seem legitimate. They focus on longevity molecules and have been selling Resveratrol since 2006. They offer a micronized resveratrol that comes in powder form, and thus could be taken in the morning with yogurt, as David does. If like me, you’re curious about the daily cost… at 1g/day it works out at $3/day ($75 per 25g tub). If you buy 2 or 3 tubs you get a discount, and it comes down to $67.50 per tub, so $2.70/day. NMN (Nicotinamide Mononucleotide) In the interview David refers to two molecules that can act as “gas” for the sirtuin activator (resveratrol) to work; NMN and NR (nicotinamide riboside). It’s not clear yet how NR compares to NMN in terms of effectiveness – those studies are still to be done. However, David speculates based on the animal studies done so far that NMN may turn out to be the superior molecule in terms of raising NAD levels in cells. When it comes to NR, there is already a clear brand leader in the space; Chromadex Tru Niagen. It’s Chromadex’s NR that also goes into other brand’s NR offerings such Life Extension’s NR. However when it comes to NMN, there isn’t a clear brand leader. Searching online there are a large number of possible options. Without doing ones own 3rd party lab testing, it’s hard to evaluate the quality of products. What I’ve done below is put some of the more highly reviewed options into a table, calculated the approximate price per gram, and added links to any 3rd party analysis certificates the companies display. Powder Double Wood (30g powder) $3.83/gram ($115 / 30g) - using $15 off coupon code Yes (link) - via Colmaric Analyticals ProHealth (15g powder) $4.60/gram ($69 / 15g) Yes (link) - via Micro Quality Labs Genex (15g powder) $4.60/gram ($69 / 15g) Yes (link) - via Micro Quality Labs RevGenetics Advanced NMN (25g powder) $15.8/gram ($395 / 25g) Yes (link) - via Intertek Capsules Double Wood (125mg capsules) $5.86/gram ($44 / 7.5g) - using $5 off coupon code Yes (link) - via Colmaric Analyticals ProHealth (150mg capsules) $5.44/gram ($49 / 9g) Yes (link) - via Micro Quality Labs Genex (125mg capsules) $6.66 ($50 / 7.5g) Yes (link) - via Micro Quality Labs.
For further information on the topic of Resveratrol and NMN, see this longer post I did on David Sinclair’s Supplements – What He Takes & Where to Buy – including additional information we’ve learnt since David was on JRE. In a January 2019 podcast episode (JRE #1234 ), Joe discussed the 3 nootopic supplements he likes & takes; Neuro1, TruBrain & AlphaBrain. The 3 Nootropic Supplements Joe Rogan Takes – YouTube Clip. I use 3 different companies, 1 that’s one of mine (AlphaBrain), and then 2 that are other companies; Neuro1 and another one called TruBrain” Neuro1. Joe has mentioned Neuro1 numerous times over the years (for example see Joe’s below tweet from 2013).
It’s a nootropic created by former NFL linebacker Bill Romanowski, who after 16 years, and many hits in the NFL, was suffering from memory problems. In 2007 he brought together doctors, scientists and nutritionists to create a solution to fix his cognitive decline. More about Romanowski and the creation of Neuro1 here, and the product’s website link here.