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In a very short time, CBD oil has grown rapidly to become a 270 million market, which is expected to be valued at close to 20 billion by 2024. Jing Yingli is so generous and helps He made suggestions, and he was very grateful TheXu Luo Dan is so precious that even if Jing Yingli doesnt use it. If you have an inflammatory disease which is causing you pain, then try some CBD oil and you should see that pain dissipating in no time. Its just that they didnt expect that what the master refiner now refined was actually a highgrade flying spirit weapon, which was beyond their expectations. Drugs have shown to have major or clinically significant reactions include Morphine Tramadol Norco So while the information we have now is currently sparse, the list will continue to grow as we do more research. Ye Mo also understood why the catastrophic monk wanted to chase and kill the Bianfeng Pagoda just now, because thecatastrophic pill was the main medicine for the cultivation of the catastrophic monk. This oil is cheaper than most of the other premium CBD oils Ive tried, comes in a full range of potencies, and uses some of the best fullspectrum hemp extracts Ive ever seen. However, when the news came out that Richard accepted the three goddesses and was preparing to fight the invaders to the death, many nobles in the Sequoia Kingdom immediately changed their minds and transferred back all the troops originally prepared to join the royal expeditionary army and applied to join Li The team of observation. She handed the spirit weapon long sword to Ye Mo and said Give you a spirit weapon first Even if it is lost, I will stab this brute with a few swords Obviously she saw that Ye Mo did not have a storage ring. At this moment, both Teng Xiong and that cultivator on Yutian Island seemed to be relieved, and apparently Pure Hemp Farms Cbd Nugs Pineberry they sensed the spirit mark on Ye Mo again. Also, because research into CBD is scarce, nobody really knows the most effective therapeutic dose of CBD for any medical condition But experts say the evidence is scant for most of these touted benefits. Because as long as Jing Xiangdong If you dare to help yourself in this situation, you must become a deadly enemy with Yong Lanyi, and it is possible to fight on the spot Brother Jing I and Yong Lanyis old man are deadly enemies If this is the case, it will be fatal You are here, Brother Jing Ye Mo pushed back the jade card. and said softly in the bottom of his heart I caught you Immediately, the order was sent down to that section of the wall through the soul link There are thirtyseven Dark Front knights alive. For CBD, you want the percentage to vary from 3 300mg to 18 1800mg THC percentage When it comes to THC content, the lower, the better You want it to be lower than 0 2. You must know that even if it is Jing A genius monk like Yingli is also a core disciple of the sect, and she cant find the Fourth Grade Pill King to help her refine the Xuluo Pill let alone the rest of the disciples So the sect disciples will basically take out their own collection Medicinal materials in exchange for contribution Minute. And because Epidiolex consists of purified CBD oil extract, it is safe to say FDA approval is a clear indication of its high safety standards. So the thing Im most honored to do is to meet a younger brother like Ye Mo Youre right, Ye Mo got theXianghua Flower in the Fallen Soul Ruins I just wanted to ask about the situation in the Luohun Ruins. 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However, in December 2015, the FDA eased the regulatory requirements for CBD, which allowed for more research into CBD and trials are now underway investigating its benefits for Parkinsons disease, schizophrenia, diabetes. While CBD oil products have been all the rage in the United Kingdom nowadays, finding the right fit for you may not be that easy For one, there is a myriad of brands to choose from making it hard to figure out where to start. After all, those laundry lists of possible sideeffects that make you panic and give you a headache come from years of research and observation! Here are some of the CBD side effects that have been reported so far These are all side effects some people have experienced Theres no guarantee you will feel any of these effects or that you wont feel effects that arent on this list. 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Medical Cannabis

Anatomy of Cannabis Plant

Cannabis is a genus of flowering plants in the family Cannabaceae. This family that also includes the hemp plant produces fibrous stalks and offers diverse utility for multiple purposes. A documented historical use of medical cannabis for symptomatic relief has been reported for over 5 centuries. The leaves, flowers, and roots have noted medicinal use throughout the world in: China, India, Israel, the United Kingdom, and Canada. Cannabis leaves and flowers are traditionally consumed in several forms. Cured flower (bud) is more commonly available compared to various types of concentrated, loose or pressed resin extracted directly from the cannabis plant. As the cannabis plant matures from its vegetative state to the flowering phase, the development of trichomes (tiny, crystal-like glands containing cannabinoids and terpenes) will be visible and abundant on the cannabis fan leaves, stems and flowers.

Together, the chemical compounds of cannabinoids and terpenes, an array of natural resinous essential oils, provide physical, psychoactive, and therapeutic effects in a combined, complimentary action. The potency of cured cannabis depends on the wide range of cannabinoids, which are chemical compounds that act in the body to stimulate a “lock-and-key” effect. The popularity of cannabis’ best-known psychoactive properties (the mind-altering, euphoria-inducing “high”) is due to delta-9-tetrahydrocannabinol (THC), and its pain-relief, anti-inflammatory, and anxiety reducing benefits (among others) to the non-psychoactive cannabidiol (CBD). These cannabinoids are naturally found in cannabis so they are also known as phytocannabinoids, or naturally occurring plant cannabinoids; as different chemicals, THC and CBD have different alleviating effects for certain symptoms.

THC and CBD act at specialized and natural receptors found in the body known as the CB1 and CB2 receptors. The term “cannabinoids” broadly applies to the natural phytocannabinoids (chemical compounds organically found in the cannabis plant) and endocannabinoids (chemical compounds which are automatically produced by the body) to make up the Endocannabinoid System (ECS).

The ECS acts as a biological balancing mechanism in the body through various processes (or homeostasis). Through different methods of administration, varying levels of THC and CBD will be available in the body. The onset of effect varies depending on the form of administration, which alters THC and CBD entry into the bloodstream for symptom relief. The two most common methods for consuming cannabis are inhalation (smoking or vaporizing) and ingestion (prescription synthetic capsules or edibles).

Mechanism of Action

THC binds to cannabinoid receptors in the brain
THC interferes with endogenous neurotransmitters
Biological Effects Occur

By the 1960s, scientific research established enough evidence to prove that the Endocannabinoid System (ECS) exists naturally in humans and animals. Because the cannabis plant produces phytocannabinoids that act similarly to the endocannabinoids naturally produced by the human body, this communication system within the body involves receptors that bind to all types of cannabinoids in a lock-and-key effect for symptom relief through multiple pathways. THC and CBD will mimic natural cannabinoids to help regulate the body’s numerous biological responses, including pain.

Minor Cannabinoids

THC and CBD are the most commonly discussed and prevalent phytocannabinoids in the cannabis plant, but they are not the only ones. There are over 100 other minor cannabinoids working simultaneously when consuming cannabis as a whole plant. Currently, there is limited knowledge and understanding of individual effects of these minor cannabinoids due to cannabis being scheduled as a Class 1 Controlled Dangerous Substance by the DEA. This federal designation hinders clinical research being done at larger, substantial scales. The limited studies surrounding these minor cannabinoids have shown promising results so far. A few examples include using cannabinol (CBN) to help with insomnia, cannabigerol (CBG) used a neuro-protective agent, cannabichromene (CBC) to reduce inflammation and tumor growth, and tetrahydrocannabivarin (THCV) to help regulate blood sugar and insulin levels.

Cannabinol

helps with insomnia

Cannabigerol

used as a neuro-protective agent

Cannabichromene

reduces inflammation & tumor growth

Tetrahydrocannabivarin

regulate blood sugar and insulin levels

Know Your Terpenes

Along with your major and minor cannabinoids, every single cannabis plant has a unique odor and fragrance linked to their plant genetics. Terpenes are responsible for the distinct smells of citrus, pine, berry, and even fuel depending on specific strains. Some cannabis plants have been described to have either sweet or skunky undertones and all contribute to the complexity of the plant. Terpenes are produced by the same mechanisms as cannabinoids and can vary in concentrations depending on environmental factors such as temperature, humidity, and soil types.

Having a unique smell is beneficial in being able to identify strains, but research has also shown that terpenes provide medical benefits as well. There have been over 100 terpenes identified and each has been studied to some degree showing positive traits for inflammation, bronchodilation, and antioxidation. Terpenes combined with cannabinoids of the plant work side by side producing what’s known as the entourage effect. This synergistic relationship means that consuming the whole plant will have a larger benefit than using individual cannabinoids. Above are a handful of the most common terpenes found and their medical uses.

Decarboxylation

Cannabinoids in its raw form on the cannabis plant need to be activated in order to produce medicinal benefits. Sometimes, you will see the term “THCa” (Tetrahydrocannabinolic acid) and “CBDa” (Cannabidolic acid) listed when describing cannabis strain potencies. The “a” or acid molecule is removed by adding a heat source to the plant to activate the cannabinoids. Traditionally, using a heat source like a lighter will heat up cannabis beyond 451 o F, burning the entire plant up. This process is called combustion and produces smoke that you inhale through the lungs. The cannabinoids are being activated, but the entire plant is burned in the process leading to the added inhalation of toxins and carcinogens.

Newer methods of activating cannabinoids in the cannabis plant is through a process of vaporization. This process involves maintaining the cannabis plant cannabinoids at a steady temperature under the point of combustion of 451 o F. This process activates the cannabinoids and releases vapor that is inhaled instead of smoke. Every cannabinoid and terpene has a different temperature at which it is activated, so being able to adjust the temperature of vaporization will produce different flavors, and more importantly, different medicinal effects.

Indica

Sativa

The origin of the commonly mentioned terms Indica and Sativa come from the official scientific plant name. Cannabis Sativa are cannabis plants cultivated in hotter climates usually surrounding the equator. They usually grow taller and are characterized by longer, thinner leaves. Cannabis Indica are cannabis plants cultivated under more harsh environments and typically have broader, wider leaves. However, over time, these two terms have been adapted to describe the physical and cerebral effects typically felt when consuming these plants. This chart highlights some of trait differences between Indica and Sativa cultivars.

Indica

Generally sedating, relaxing & soothing

Better suited for night time usage

Described as more of a “body high”

May help with sleep, relaxation & muscle spasm

Sativa

Generally energetic, uplifting & happy

Better suited for day time usage

Described as more of a “head high”

May help with focus, creativity, and mood

Over the years, cannabis horticulturists have bred both Cannabis Indica and Cannabis Sativa plants together to create a separate class of plants called Hybrids. Hybrids were created to take the desired features of each Indica and Sativa strain and combine them to highlight their best qualities. Hybrids are usually not a perfect 50/50 blend of sativa or indica, but you may hear them referred to as being indica-dominant, or sativa-dominant. They maintain characteristic traits of both their parents to create an entirely new combination of cannabinoids and effects. Usage of these plants will vary and a dispensary technician should be consulted for specific characteristics of these cultivars.

Cannabis Explained from Head to Toe

Improves global symptoms of PTSD including enhancing
sleep quality, reducing frequency of nightmares, and reducing
hyperarousal severity

May prevent or slow the development of Alzheimer’s Disease
Shown to have an analgesic effect and reduce pain associated
with migraines

Reduces pain perception and improves spasticity in patients
showing symptoms of Multiple Sclerosis

Has been suggested to aid in preventing spontaneous
epileptic seizures

The active components of cannabis interact with the brain’s pleasure centers; constant ingestion has been linked to psychological dependence and addiction. However, it is believed to be significantly less addictive than harder drugs
(e.g. heroin or cocaine).

A 1994 study measured the addictive potential of several common drugs by quantitating the percentage of participants showing dependency.

According to their data:
Tobacco: 32% became dependent
Heroin: 23% | Cocaine: 17% | Alcohol: 15%
Cannabis: 9% became dependent

Eyes

Cannabis has been shown to transiently lower intraocular pressure (IOP) associated with glaucoma, although not as effectively as prescription medication.

Chest

Cannabidiol (CBD), an active component in cannabis, has been shown to hinder the expression of the transcription factor ID-1, a key regulator of the metastatic potential of breast and other cancers.

Pancreas

In one study, cannabis use was associated with lower fasting insulin levels, reduced insulin resistance, and similar waist circumference.

Intestines

Two compounds in cannabis, THC and CBD, have been shown to improve symptoms of Crohn’s Disease.

Hands

A cannabis-based medicine (CBM), Sativex®, may reduce pain associated with Rheumatoid Arthritis (RA) and significantly suppress disease activity.

Muscles

Studies have shown that cannabis significantly reduces muscle spasticity, a condition characterized by prolonged and involuntary muscle contraction, resulting in stiffness and rigidity.

Cannabis Short-Term & Long-Term Affects (Potential)

Potential Side Effects of

Cannabis Consumption

Unintentionally consuming too much cannabis, or accidentally over-medicating, is rare and most likely to happen to patients who have little to no previous experience. To avoid this risk, use the “Start Low & Go Slow” method: initially, start with a small dose and titrate up (or gradually increase the dose) as needed until symptom-relief is achieved.

Over-medicating with cannabis can trigger acute anxiety or panic, increased heart rate, low blood pressure, dry mouth and red eyes. Overestimating the potency, or strength, of the cannabis may result in unintended over-medicating and the patient may need to reduce the amount of cannabis administered in the future.

Possible Effects of Cannabis

Psychological

  • Hunger
  • Lowered Body Temperature
  • Lowered Immune Response

Psychomotor

  • Impaired Motor Skills
  • Slowed Reaction Time
  • Altered Peripheral Vision

Cognitive

  • Short-Term Memory Damage
  • Impaired Perception
  • Impaired Cognition
  • Impaired Learning Ability

Dependency Potential of Cannabis

Low Risk

With chronic excessively frequent cannabis use, approximately 10% of heavy cannabis users may develop a dependency on cannabis.

Side Effects & Remedies

Coughing

  • Reduce amount of smoke/vapor being inhaled
  • Drink some cold water after coughing subsides

Rapid Heart Beat

  • Usually resolves around 15-20 minutes after consumption
  • Breathe deeply and slowly for a few minutes
  • If accompanied by chest pain, contact an emergency healthcare professional immediately

Dry Mouth

  • Drink beverages like water or lemonade
  • Use citrus flavored gum or lozenges to increase saliva production

Red Irritated Eyes

  • Use over the counter eye lubricant eye drops or ointments

Dizziness / Lightheaded

  • Keep your eyes open and focused on something until symptoms resolve

Short-Term Memory Loss

  • Completely reversible when usage is decreased or stopped completely

Psychoactive Effects

Use the 4-7-8 Technique

  • Sitting comfortably, empty your lungs through the mouth with a whoosh.
  • Close your mouth and fill your lungs by inhaling through your nose on a mental count of four.
  • Hold your breath for a count of seven, then slowly exhale through the mouth, with a whoosh, over a count of eight.
  • Repeat four times or until your symptoms are better.

If you experience any mental changes or physical discomfort of any kind that has not been discussed, notify your certifying prescriber immediately.

Some patients initiate cannabis while actively taking prescription medications. You should check with your certifying prescriber or dispensing pharmacist for any drug-drug interactions that may occur while using medicinal cannabis.

Stopping, starting, and/or changing any of your medication therapy- including over the counter items is not recommended while using cannabis without the direct supervision of your prescriber.

Cannabis Forms of Administration

There are a broad range of options for routes of administration which patients can choose from based on individual lifestyle choices. Cannabis can be smoked or vaporized.

Also, ingested in food or beverages (these edibles can be home-cooked and prepared as “infused” cannabis combined with fat-soluble cooking mediums such as salt-free butter or coconut oil.) Another route is where it can be absorbed sublingually (under the tongue i.e. lozenge). A different route can be used topically (applied locally to the skin on affected areas of the body i.e. creams, lotions or ointments).

Safety profiles have not been established for other potential forms of cannabis delivery including:

Transdermal, rectal, and sublingual forms; these options may minimize potential risks experienced with common methods of cannabis administration. Clinical research focusing on cannabinoids has led to several FDA-approved medications that contain synthetic cannabinoid(s) in pill or liquid form.

Vaporizing vs Smoking

Vaporization is a form of inhalation that involves heating cannabis to produce steam or vapor instead of directly burning the cannabis to combustion. The devices (specifically known as vaporizers) are equipped to heat the marijuana to a temperature ranging from 356°F to 374°F in order to vaporize THC without

burning plant materials as “smoke.” Smoking devices that use water filters (i.e. bongs or water pipes) have been shown to involve equal amounts of tar in comparison to smoking cannabis using a glass pipe, blunt, or joint and these water filters do not reduce potential risks of cannabis smoke and inhalation.

Vaporizing

Smoking

Edibles, Beverages & Other Forms

Edibles

Other Forms

Dosing Forms Available

Flower

Also known as nuggets, nugs, or bud. Female flowering part of the cannabis plant that produces cannabinoids. It is usually ground down and smoked/vaporized, or can be infused into oils or butters to prepare edibles with.

Shake

Finely ground cannabis flower that can be consumed or prepared in all the ways regular flower is used right out of the container.

Pre-Rolls

Flower or shake that is rolled into a cigarette form using a filter and unbleached rolling paper, also ready to use out of the bag..

Concentrate Oils

Cannabinoids are extracted and refined from the cannabis plant into a more purified and potent form. They can be smoked, vaporized, used to cook edibles, or applied directly in the mouth as a tincture.

Concentrated dabs/wax/shatter/rosin

Cannabinoids that are extracted and refined from the cannabis plant into extremely high concentrated and potent solid/semi-solid states. They are usually consumed by smoking or vaporization only.

Tropical Formulations

Lotions, ointments, balms, and creams can be great for local application of specific areas of the body for arthritis or pain.

Sublingual tinctures/lozenges

Absorption of cannabinoids through the buccal or sublingual route leads to a quick and clean option..

Capsules

Activated cannabinoids that can be swallowed by mouth similarly to other medications. Dosing options are more precise and can be increased or decreased accordingly.

Suppositories

Applied rectally for patients that do not have the ability to intake anything orally, have severely impaired lung function, or have an inoperable digestive tract..

Transdermal patches

Patches that are applied to the skin that allows for a slow release of cannabinoid(s) throughout the day. Application can be discreet and hidden under clothing.

Onset & Duration

Dosing

One of the primary concerns that every new patient will experience is “how much do I use for my particular condition?” Unfortunately, there are currently no officially recognized therapy protocols or guidelines found like with traditional prescription medications. We encourage patients to follow a concept called microdosing which is simply to “start low, and go slow.” You will start with the smallest dose possible, and gradually increase the dosage in controlled increments until you achieve the desired response for your condition. This fine tuning process will allow you to maximize outcomes while limiting the amount of adverse effects you may experience. Also by using the most minimal amount of medication, you will reduce your out of pocket costs from wasting excess.

These are a few tips that can help you get started with microdosing. Start with one small dose. Whether it be 1 puff, 1 lozenge, 1 capsule, or 1 application, keep it simple. Repeat the same dose in 10-15 minutes if symptom relief is not achieved. You should wait between 1-2 hours for orally ingested medicine due to a longer onset of action.

Repeat this step as many times as needed until you do achieve the desired effect. Going forward, this will be your established baseline dose. The next time you need to medicate, start with your baseline dose and medicate as frequently as you feel necessary. Keep in mind, that the higher the dose and more frequently you medicate, the more you are also at risk for adverse effects. From time to time, doses may need to be increased or decreased based on therapeutic relief or unwanted side effects. We encourage and recommend that you keep a cannabis log to document cultivars used, number of doses, frequency of doses, and comments on effects. This will help you take more of a scientific approach to your cannabis therapy and will help the dispensary technicians give additional recommendations if needed.

Dosing methods and strain selection will be dependent on your lifestyle habits, tolerance levels, and physical capabilities. The most important takeaway is that you, the patient, be 100% comfortable with using and administering your medical cannabis on your own.

Medical Cannabis Anatomy of Cannabis Plant Cannabis is a genus of flowering plants in the family Cannabaceae. This family that also includes the hemp plant produces fibrous stalks and offers