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Cannabinoids and the skeleton: from marijuana to reversal of bone loss

Affiliation

  • 1 Bone Laboratory, the Hebrew University of Jerusalem, Jerusalem, Israel. [email protected]
  • PMID: 19634029
  • DOI: 10.1080/07853890903121025

Cannabinoids and the skeleton: from marijuana to reversal of bone loss

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Authors

Affiliation

  • 1 Bone Laboratory, the Hebrew University of Jerusalem, Jerusalem, Israel. [email protected]
  • PMID: 19634029
  • DOI: 10.1080/07853890903121025

Abstract

The active component of marijuana, Delta(9)-tetrahydrocannabinol, activates the CB1 and CB2 cannabinoid receptors, thus mimicking the action of endogenous cannabinoids. CB1 is predominantly neuronal and mediates the cannabinoid psychotropic effects. CB2 is predominantly expressed in peripheral tissues, mainly in pathological conditions. So far the main endocannabinoids, anandamide and 2-arachidonoylglycerol, have been found in bone at ‘brain’ levels. The CB1 receptor is present mainly in skeletal sympathetic nerve terminals, thus regulating the adrenergic tonic restrain of bone formation. CB2 is expressed in osteoblasts and osteoclasts, stimulates bone formation, and inhibits bone resorption. Because low bone mass is the only spontaneous phenotype so far reported in CB2 mutant mice, it appears that the main physiologic involvement of CB2 is associated with maintaining bone remodeling at balance, thus protecting the skeleton against age-related bone loss. Indeed, in humans, polymorphisms in CNR2, the gene encoding CB2, are strongly associated with postmenopausal osteoporosis. Preclinical studies have shown that a synthetic CB2-specific agonist rescues ovariectomy-induced bone loss. Taken together, the reports on cannabinoid receptors in mice and humans pave the way for the development of 1) diagnostic measures to identify osteoporosis-susceptible polymorphisms in CNR2, and 2) cannabinoid drugs to combat osteoporosis.

The active component of marijuana, Delta(9)-tetrahydrocannabinol, activates the CB1 and CB2 cannabinoid receptors, thus mimicking the action of endogenous cannabinoids. CB1 is predominantly neuronal and mediates the cannabinoid psychotropic effects. CB2 is predominantly expressed in peripheral tissu …

CBD/CANNABIDIOL PROMOTES BONE GROWTH

It has been known for a number of years that CBD helps promote bone growth.

There are two major cell types involved with both growth, destruction and “re-modeling” of bone. As we go through life our bones are subjected to new and changing stresses. New bone is always taking place and bone destruction or resorption is always taking place.

Osteoblasts, create new bone and Osteoclasts resorb and help to remodel bone as stresses change.

It is the balance of these two processes that determine if we get more bone laid down or we lose more bone. With aging, hormonal and other changes, in general bone density drops with age. We all know plenty of elderly people with hip or other fractures from very minimal stress. In fact, most hip fractures occur BEFORE the person hits the ground. There is a “Torque” pressure that initially causes the fracture and then the fall takes place. The point being, the patient’s bone strength is extremely brittle.

Additional Information

So, in a new article, new data shows improved bone growth and fracture healing with CBD. There is also a review article,that is a good read and also goes into treatment of osteoporosis.

As CBD is harmless, here is one more great use of CBD for prevention of bone loss and help in restoring stronger bone after a fracture.

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It has been known for a number of years that CBD helps promote bone growth. ]]>