“The stereochemistry of this compound suggests it may possess interesting clinical potential with minimized psychoactive side effect,” explained Raber. “Obtaining significant quantities of pure compound may be challenging initially, but viable natural based or synthetic routes may both be developed should it prove of interest to do so.” PET less psychoactive compared with THC. It’s well known that low doses of THC may offer therapeutic potential when it comes to treating various chronic illnesses.
But THC is limited from a therapeutic standpoint due to a strong psychoactive effect at higher doses, other than being illegal at this time. As previously mentioned, in contrast to THC, PET inhibits the production of inflammatory prostaglandins in the brain. As a result, PET likely has an effect on cannabinoid receptors which interact with our endogenous endocannabinoids. Certainly more preclinical studies of various models of chronic and inflammatory pain will be necessary to better understand its role in this setting. To obtain adequate amounts of PET from the liverwort plant, Gertsch collaborated with his colleague, Erick Carreira, whose team developed a new synthetic way to preserve the 3-D structure of the compound on a molecular level. "The present study is a prime example of how new synthetic concepts can make a contribution towards enriching our pharmacological knowledge of biologically-active natural substances", said Michael Schafroth, PhD, who studied and worked under the direction of Dr. "Both solid fundamental research in the field of biochemical and pharmacological mechanisms as well as controlled clinical studies are required to carry out cannabinoid research", added Gertsch. With recent legalization of Cannabis in Canada helping to support ongoing support for research and patient interest in using combinations of CBD and THC to treat common conditions such as endometriosis, fibromyalgia and IBS, it’s becoming more apparent that the endocannabinoid system and its associated deficiencies may hold the key to relieving pain and alleviating bothersome symptoms that are difficult to treat. Use of CBD (Epidiolex, GW Pharmaceuticals) to treat intractable seizures associated with Dravet syndrome and Lennox Gastaut Syndrome, along with THC (2.7 mg) and CBD (2.5 mg) per spray (nabiximols, Sativex , GW Pharmaceuticals) to treat spasticity associated with MS is supported by published research and has emerged as a viable way to manage these difficult-to-treat conditions when available and standard approaches yield minimal improvement.
As clinicians seek less harmful modalities than opioids for treating chronic pain, PTSD, gastrointestinal, and autoimmune disorders, liverwort and its derivatives may hold promise as a safer therapy. The road to get there will involve not only refining methods of extraction and purification, but a significant amount of preclinical studies in animal models, before it’s ever tested in humans. “2018 has seen the phenomenal rise of Cannabis and hemp (CBD) as an alternative therapy to alleviate the symptoms of pain, epilepsy, PTSD, MS, fibromyalgia, endometriosis, GI disorders, and many other chronic conditions,”said Rich Able, a medical device consultant based in Seattle. “This is a very exciting time as big liquor and big pharma companies have invested billions of dollars into Cannabis ventures and clinical labs throughout the year,” offered Able. “This trend will continue as clinicians potentially investigate safer plant-based alternative therapies such as liverwort.” “Known plant-based compounds like this one [PET] can be challenging to protect with patents, which is one reason why they may not be prioritized by industry,” said Greg Wesner, Chair of Lane Powell’s Intellectual Property Litigation Team, based in Seattle. "Nevertheless, even if the active pharmaceutical ingredient (API) itself is not patentable as a chemical entity, it may be possible to obtain patent protection for a drug candidate that combines the API with an effective, patentable drug delivery technology.” “Moreover, the API could be the subject of a method of treatment patent if the API is discovered to be a novel treatment for a disease indication,” added Wesner. White's "Charlotte's Web" A classic story that deals with of the nature of friendship and loss. M.A., English Literature, California State University - Sacramento B.A., English, California State University - Sacramento. First published on October 15, 1952, "Charlotte's Web" is a popular children's book written by acclaimed American author E.B. White and illustrated by Garth Williams that deals with themes of the nature of friendship, loss, fate, acceptance, and renewal. The story centers on a pig named Wilbur and the unlikely but deep friendship he shares with an uncommonly talented spider named Charlotte. While it's normal in the course of events on a farm for pigs to be slaughtered when they reach a certain size and age, cunning Charlotte hatches a scheme to keep Wilbur from his fate by weaving words into her web to create what amounts to a one-pig publicity campaign. By elevating Wilbur to celebrity status, Charlotte ultimately saves him from his date with the butcher's knife. The ending of the "Charlotte's Web" is bittersweet, however, because while Wilbur survives, Charlotte does not. But even Charlotte's passing is a lesson—for Wilbur and those reading his story—about the nature of death and renewal. Death and destiny are both themes that the book explores. While Charlotte is willing to help Wilbur dodge a destiny that's being imposed on him by outside forces beyond his control, she also understands that some fates are inevitable: All living creatures are born, have a life cycle, and die. Charlotte accepts her role in this natural circle without remorse. Charlotte helps Wilbur realize that immortality is not about living forever, but rather, ensuring that new generations will follow. She also helps him understand that love and friendship are not finite in quantity. While we may lose a friend, new friendships can come along, not as replacements for what we've lost, but as blessings to build on what we've learned. Quotes From "Charlotte's Web" "Wilbur didn't know what to do or which way to run.
'If this is what it's like to be free,' he thought, 'I believe I'd rather be penned up in my own yard.'" "Wilbur didn't want food, he wanted love." "I am a glutton but not a merrymaker." "[W]hen your stomach is empty and your mind is full, it's always hard to sleep." "It's true, and I have to say what's true." "'Well,' he thought, 'I've got a new friend, all right. Charlotte is fierce, brutal, scheming, bloodthirsty—everything I don't like. How can I learn to like her, even though she is pretty and, of course, clever?'" "There's a regular conspiracy around here to kill you at Christmastime." "If I can fool a bug. People are not as smart as bugs." "It seems to me you're a little off. It seems to me we have no ordinary spider." "But nobody pointed out that the web itself is a miracle." "I don't understand it, and I don't like what I don't understand." "It is quite possible that an animal has spoken to me and that I didn't catch the remark because I wasn't paying attention." "No one was with her when she died." "She was in a class by herself. It is not often that someone comes along who is a true friend and a good writer. Charlotte was both." The Power of Words in "Charlotte's Web" Lesson Question: Applicable Grades: Lesson Overview: Length of Lesson: Instructional Objectives: analyze how E.B.
White indirectly characterizes Wilbur (through different characters' perspectives) use the Visual Thesaurus to define and explore key adjectives from Charlotte's Web use the Visual Thesaurus to identify adjectives to describe their peers play a game to identify adjectives by receiving synonym clues. White's Charlotte's Web (one per student) student notebooks white board computers with Internet access computer printer and paper (one sheet per student) Note: This lesson was designed as a post-reading activity for students who have recently either read Charlotte's Web or have listened to the novel being read aloud in class. Warm-up: Analyzing a quotation from Charlotte's Web : Read aloud Mrs. Arable's description of Wilbur on the opening page of Charlotte's Web: ". It's very small and weak, and it will never amount to anything.