This will be especially important for synthetic CBD that is reportedly now being made in uncertified labs in China and making its way into the U.S. However, because the scheduling status of CBD in Hawaii remains unknown, because CBD products being sold in Hawaii are currently completely unregulated, and because most CBD manufacturers do not provide lab testing results for their products, the only way to know for sure whether a hemp-CBD product is free of contaminants, and contains the amount of CBD being advertised, is to have such products tested for yourself. Luckily, there is an accredited state-licensed cannabinoid analytical lab in Hawaii that is able to legally accept samples directly from patients and the general public and performs testing at a reasonable cost. CBD has been shown to inhibit CYP3A4 , a liver enzyme found in humans that is responsible for metabolizing a significant number of commonly used pharmaceutical medications.
Some of the more dangerous potential drug-interactions include prescription medications such as Coumadin, Hydrocodone, Ambien, Amlodipine, Losartan, Viagra, and Xanax. One study has shown that as little as 25 mg of CBD can inhibit CYP3A4 function. Potential interactions with CBD can be checked using Medscape’s Online Drug Interaction Checker , by first inputting “ grapefruit ”, which also inhibits CYP3A4, and then inputting the medication of interest. Potential interactions will be displayed along with the associated warnings. Because of these potential drug interactions, all certification examinations should include a review of current prescription medications and their potential interaction with CBD. Products containing CBD should also include a drug interaction warning. Patients wishing to take CBD on a daily basis need to be followed by their Primary Care Physician in order to monitor for potential drug-interaction side effects and to consider adjusting the dose of the affected prescription medications if side effects occur.
While CBD-drug interactions could be potentially life threatening depending on the dose of CBD, close supervision of patients using CBD on a daily basis may allow for dosages of the affected medications to be reduced while still having the same therapeutic benefit, thereby reducing the associated side effects that these prescription medications can have by themselves. Most medical use of cannabis states recognize Glaucoma as a qualifying condition for their medical use of cannabis programs. There are also still a few remaining patients in the FDA’s Compassionate Investigational New Drug Program , one of whom qualified for this federal program based upon her glaucoma. Unfortunately, very little research has been done on the effect of CBD on intraocular pressure (IOP). Even the clinical trials that were conducted for the FDA approval of Epidiolex, did not look at changes in IOP in their study subjects (personal communication). However, a recent study looking at the effect of topically applied THC and CBD in mice not only found that THC significantly lowered IOP, but that CBD also seemed to block the IOP lowering effect of THC, and caused an elevation of IOP when given alone. What this means is that we now need to look at the possible effect of CBD on IOP in humans, especially with the number of people who are using locally available unregulated CBD products to treat a variety of medical conditions without proper medical supervision. Until such data is available, patients who are taking CBD on a daily basis should consult with their certifying physician and their PCP about this potential side effect, and consider having their IOP followed by a licensed Optometrist or Ophthalmologist while taking CBD. Disclaimer: The information on this website is for educational purposes only, and is not intended as legal or medical advice. This website is also an exercise in freedom of speech, and is afforded all the rights and protections of our Constitution. Furthermore, we have no commercial interests in any of the products or companies mentioned on this website. Please consult with a lawyer for professional legal advice on the Medical Use of Cannabis in Hawaii. CBD Oil Review rates the CBD Plus USA Brand with two stars because it qualifies for the Mission & Quality Badges. CBD Plus USA is the self-described safe, legal, affordable CBD solution. This Oklahoma operation has their sites set on nationwide domination. But they’re following a disturbing trend right now in the CBD space — ‘all-natural’ claims that don’t check out. We can forgive a couple of artificial ingredients, but it’s a dishonest move when you proudly tout your product line as all natural. And the use of parabens in their CBD topical is non-excusable. We’re holding off on our approval until some changes are made. Learn 10 reasons why CBD Living is our top choice and SAVE 20%! Based out of Oklahoma, CBD Plus USA aims to offer a no-nonsense, honest alternative to pharmaceuticals. Like many CBD vendors, they’re working to banish the stigma surrounding cannabis and normalize all-natural care. Their stated goal is to become the largest and most trusted CBD supplier in their home state and eventually, the entire country.
CBD Plus USA’s CBD is sourced from domestically grown, non-GMO hemp, but we are unsure as to their extraction method, since they only say their CBD is ‘carefully extracted’. If CBD Plus USA wants to become the kind of powerhouse they are aiming to be, we highly suggest they disclose this information. Also, they currently only post cannabinoid profiles for their CBD products. In order to qualify for our Safety Badge, we need to see contaminants tests for each batch of CBD oil used to make product or for every SKU. CBD Plus USA manufactures their products under the name Colorado Cures. Their capsules have the moniker CBD Plus USA, but perhaps these will be slowly phased out in favor of the new Colorado Cures name. The company claims their products are made from all-natural ingredients, and their lineup includes the following options: CBD Isolate Tinctures Broad Spectrum CBD Tinctures CBD Vegan Gummy Bears and Taffy CBD Topicals CBD Med Cones CBD Capsules CBD for pets, water, wax kits, vape, and vape accessories manufactured by third-party vendors. Sometimes, we have to call out companies for making dishonest claims, and that’s exactly what we’re going to do here. CBD Plus USA blatantly states, “Our products are all-natural,” but we found evidence to the contrary. The company’s taffy contains artificial flavors, and we found some downright scary ingredients in their CBD topical product called hemphreeze.
This product not only contains phenoxyethanol, but multiple parabens, including butylparaben (one of the worst).