Moreover, the Food and Drug Administration (FDA) has already approved Epidiolex, an oral solution containing CBD, to treat children aged two and older suffering from these diseases. The study conducted by the team from the Neuropsychopharmacology journal demonstrated that CBD products could be used to treat cognitive impairment or anxiety. Soldiers participating in various attacks often suffer from post-traumatic stress disorders and don’t visit places or activities associated with such events due to bad memories and jitteriness. The Department of Veterans Affairs even spent money on the first CBD study to make sure that CBD products could help these people manage their condition.
According to Mallory Loflin, a principal investigator of the study, CBD gives a chance to cope with these disorders faster than in case of conventional drugs. One of the research investigating the effect of CBD on sleep or depression was described in Journal of Chemical Neuroanatomy. The participants of the study reported that cannabidiol acted faster and better than antidepressants. Moreover, the studies in animals exposed to chronic stress revealed that rats and mice treated with CBD products were more resilient than those that received nothing. According to the study described in Current Neuropharmacology, CBD’s pain-relieving effects allow the compound to lower pain perception levels and inflammation when it interacts with our vanilloid receptors responsible for pain pathways. Another study put out in the European Journal of Pain in July 2016 suggested that CBD products could be effective and helpful in the treatment of arthritis. Cannabidiol-containing products are often used by patients suffering from cancer to alleviate the side effects caused by chemotherapy and radiation therapy. CBD stimulates appetite and helps individuals cope with nausea and vomiting. The American Cancer Society also reported cannabidiol to be able to reduce tumour cells.
In July 2014, the Journal of Clinical Investigation published the study, according to which anti-inflammatory features of CBD-rich creams and lotions could be applied to solve the skin issues. In turn, the Journal of the American Academy of Dermatology conducted another study in July 2017 to investigate how CBD influences eczema and psoriasis. Patients reported reduced inflammation and itch during the treatment with cannabidiol. In February 2012, the American Journal of Pathology published the study demonstrating that CBD could reduce insulin resistance and moderate blood sugar in patients with type 2 diabetes. CBD products showed promise in combating alcohol, tobacco, cocaine, and opioid addiction. One of the preclinical studies published in Cannabis and Cannabinoid Research in June 2017 showed that CBD could be used as an alternative to opioid-based medicines that are usually used to treat pain caused by various reasons. Cannabidiol greatly lessens the risk of fatal overdose and lowers the chance of dependence compared to conventional opioids. According to the study represented by JCI Insight in July 2017, anxiety-reducing and pain-reducing effects of CBD allow the compound to lower the risk of stroke since it reduces resting blood pressure. Healthy men at the age of 19–29 received CBD in the course of the studies. At the end of the research, their blood pressure decreased by 6 mmHg. Since the interest in cannabidiol products is growing, scientists continue to conduct various studies to investigate the properties of cannabinoids and their effects. CBD has a great potential to ease the state of patients with numerous distresses, such as anorexia, multiple sclerosis, emesis, inflammation, chronic pain, epilepsy, neurodegenerative disorders (Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, Alzheimer’s disease), glaucoma, schizophrenia, osteoporosis, cardiovascular disorders, obesity, cancer, and metabolic syndrome-related disorders. If you or your relatives are suffering from any above-mentioned disorders and want to try CBD to ease distress, you should take into account that some users experience side effects when taking CBD products. The most common side effects include diarrhoea, sleepiness, fatigue, weakness, rash, decreased appetite, elevated liver enzymes, dry mouth, dizziness, mood changes, and others. Also, bear in mind that if you take other medicines or have some chronic diseases, you must consult your doctor or another medical professional to check how CBD will interact with your medication. Then, let’s see which types of cannabidiol you can find on the market. There are three main types of CBD: full-spectrum, broad-spectrum, and isolate. Simply put, full-spectrum CBD consists of the whole plant’s compounds, including all cannabinoids, such as CBN (Cannabinol), THCV (Tetrahydrocannabivarin), CBG (Cannabigerol), flavonoids, terpenes, fat acids, and waxes. CBD extracted from hemp contains less than 3% THC, while marijuana-derived CBD contains higher percentages. It has been proven that all these plant components combine their properties to produce so-called ‘entourage effect’ on the body. Take full-spectrum CBD, remove THC from it, and you’ll get broad-spectrum CBD that doesn’t lose its other cannabinoids, terpenes, as well as flavonoids. All these components found in the whole plant also create the so-called entourage effect when they work together to provide a greater therapeutic benefit. Broad-spectrum CBD oil can be dark or gold in colour, too. This type will be ideal for those who are afraid to fail the drug tests because CBD isolate is 99% pure with no other cannabinoids, flavonoids, and terpenes.
This means that it’s completely THC-free and cannot cause a positive drug test. CBD isolate is produced in the form of white powder or crystals. When made as oil, the colour of CBD isolate is very pale gold. To produce CBD isolate, it’s necessary to remove all other natural compounds of the hemp plant. In this case, CBD isolate will look like a powder or crystals. Non-toxic and safe CO2 is usually used to extract the hemp oil from the plant. Then, this concentrate is purified to take away chlorophylls, waxes, and other oils contained in cannabis. Purification is followed by the winterisation and decarboxylation processes. In the course of winterisation, CBD crude extract loses plant waxes and lipids.
Decarboxylation helps CBDA to turn into CBD using heating. After winterisation, the oil should undergo fractional distillation to get rid of contaminates, terpenes, and chlorophylls, as well as to separate CBD from other cannabinoids. Then, manufacturers use the reactor to mix the fraction with a non-polar solvent.