modafinil and marijuana

Beginners Guide to Mixing Modafinil and Weed

Modafinil Expert Review Board

MBBS, MD – Psychiatry, Consultant Psychiatrist

MBBS, Doctor Of Medicine MD

Head Modafinil Researcher

Weed is a complicated plant.

It can be both a stimulant or a depressant, a productivity enhancer or a productivity killer, and it can help us with symptoms like anxiety or make them even worse.

The trick to getting it right is to choose the right strain. Every type of weed is different and will give you different effects.

Your weed can either help your modafinil use or hurt it.

This guide aims to break the barriers and help you understand exactly how to mix weed with modafinil effectively.

We also talk about some tricks to avoid the negative side effects associated with these substances.

Table of Contents

Why Mix Weed & Modafinil?

There are many reasons why someone would want to combine weed and modafinil.

The most common reason is to reduce some of the side effects of modafinil. Others use it to boost the concentration and creativity-enhancing effects of the modafinil further.

Others mix them indirectly by taking modafinil for work or school during the day— followed by a few hits of weed later on to relax.

Is mixing modafinil and weed dangerous?

We’ll discuss this in more detail below.

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A Primer on How Modafinil Works

In order to break down how weed and modafinil mix, we need to briefly go over how modafinil actually works.

Modafinil is a synthetic, isolated chemical.

It has several distinct effects on the human body that force the brain into a waking state.

The Effects of Modafinil Include:

  1. Increases dopamine and norepinephrine levels (by inhibiting reuptake) [2]
  2. Increases the release of orexin (a key regulator of the wake portion of the “sleep-wake cycle” [3]
  3. Increases the release of histamine (which has a stimulating effect on the brain) [4]

The sum of these effects makes us feel very awake while the drug is in effect. This can last up to 20 hours depending on the dose and the size/build of the person taking it.

The reason this is so useful for increasing productivity is that it can dramatically increase the amount of productive time we have available to work on a given task. It also helps us focus on the task at hand and avoid distractions.

How we Metabolize Modafinil

From the moment modafinil enters the bloodstream, the liver begins to metabolize it (primarily through CYP3A4 enzyme species).

It converts the active compound into an inactive, water-soluble version known as modafinilic acid. The kidneys then filter this metabolite out and eliminate it through our urine.

Depending on how efficient our liver metabolism is, it will determine how fast the modafinil is eliminated from the body. Those with poor liver function may find that the effects of the drug last much longer than advertised, and those with extremely efficient liver metabolism may find the effects are shorter-lived.

A Primer on Weed (Cannabis spp.)

The active compounds in weed are known as cannabinoids.

They’re a group of around 113 different chemicals that interact with a special set of receptors found in each one of our cells. These receptors and the compounds that interact with it are known collectively as the endocannabinoid system.

Cannabinoids from the marijuana plant bind to these receptors, and activate them, to varying strengths.

The most significant cannabinoids in the plant are THC and CBD. Each one has different effects on the body.

What is THC?

THC is considered more stimulating than CBD.

It’s the main psychoactive component of the plant and offers the appetite-promoting, stimulating, and psychoactive effects of the plant.

Although marijuana plants can have highly variable THC levels, Sativa-dominant hybrid strains generally have a higher THC content than other cannabinoids.

You can also buy pure THC or have weed extracts that contain mostly THC.

The weed that’s high in THC is often described as producing a “head high” and can cause side effects like anxiety, paranoia, and insomnia.

Strains high in THC are better for complimenting the stimulating effects of the modafinil, reducing the appetite-suppressing side effects of the drug, and for recovering from an uncomfortable come-down off the drug’s effects.

What is CBD?

CBD has a more sedating effect than THC.

It’s not psychoactive but offers most of the pain-relieving, sedating anti-anxiety, and muscle relaxing benefits of the plant.

Therefore, weed strains high in CBD are better for reducing modafinil side effects like anxiety, muscle tension, headaches, and insomnia.

Indica dominant hybrid strains of marijuana are more likely to have higher CBD ratios than their Sativa counterparts.

There are— of course— exceptions to this rule.

It’s best to look at the cannabinoid profile of each strain you aim to buy rather than just assuming all Indicas will do the trick.

CBD extracts are also available and maybe the best option if your goal for mixing your modafinil with weed is for the benefits of CBD specifically.

We recommend finding a good Indica-dominant strain high in CBD to receive these benefits. It’s best to combine this form of cannabis later on as the effects of modafinil start to wind down from the halfway point.

How to Mix Modafinil & Weed Effectively

1. Using Weed to Reduce the Side Effects of Modafinil

This is likely to be the most common reason behind mixing these two compounds.

Modafinil is a powerful psychotropic drug that stimulates parts of the brain associated with the process of wakefulness. It increases neurochemical concentrations of norepinephrine, dopamine, histamine, and orexin, all of which work together to make us feel awake and focused.

As with any powerful medication, some unfortunate side effects may arise.

Weed (Cannabis indica/Sativa) offers some unique benefits that can reduce many of these side effects.

It’s important to note, however, that these benefits are highly dependant on the specific strain chosen due to the high variability of the phytochemicals in the cannabis plant.

As mentioned above, the main two cannabinoids in the marijuana plant are THC and CBD. Both of these cannabinoids will provide different benefits and different side effects.

Pros & Cons of Mixing THC with Modafinil
Pros Cons
Increases appetite suppressed by modafinil Can cause overstimulation and increase side effects like paranoia, irritability, insomnia, or anxiety
Can alleviate the adverse effects of the modafinil come-down Can increase other side effects like dehydration, fidgeting, and dry mouth
Pros & Cons of Mixing CBD with Modafinil
Pros Cons
Alleviates hyperstimulation caused by modafinil, improving side effects like anxiety, paranoia, irritability, insomnia, and anxiety. May further worsen appetite suppression side effects
Can significantly improve insomnia symptoms May reduce the overall impact of modafinil due to some opposing actions
How to Use Weed for Lowering Side Effects of Modafinil

As you can probably see, it’s not as straightforward as merely mixing your weed with modafinil to eliminate the side effects of your Modafinil. If the wrong strain is chosen, it may be ineffective or make side effects even worse.

That’s why it’s important to identify what side effects you want to reduce.

If you find modafinil is making you feel overstimulated, try a lower dose. A strain higher in CBD might have the potential in alleviating this side-effect as well.

You can find strains known to be high in CBD through tools like Your local dispensary will also likely have a good knowledge of what strains are higher in THC or CBD.

We recommend Cannatonic, or Harle Tsu if you’re not sure where to start.

If you find most of the issues with modafinil involve the comedown (feeling depressed, tired, uncomfortable), then we recommend using something more balanced or with a higher THC content (though not too high).

Aim for something with around 10-20% THC, or purchase an extract with medium THC levels and lower CBD.

We recommend Chocolope or Banana Kush for these effects.

2. Using Weed to Boost the Effects of Modafinil

Some users are mixing weed and modafinil to boost the effects of their modafinil.

Although these two compounds are very different and have separate effects on the body, some weed strains offer a similar benefit to modafinil through different mechanisms.

It can be a good way to get some extra kick out of your modafinil doses.

Use caution when mixing weed and modafinil for this reason. These two compounds can easily cause overstimulation resulting in negative side-effects like anxiety and insomnia— so approach with caution.

How it Works

One of the main ways THC can be used to boost modafinil’s effects is through one of the main endocannabinoid receptors, known as CB1.

This receptor is important for regulating dopamine release.

THC preserves dopamine levels by inhibiting the enzyme responsible for breaking it down (monoamine oxidase) [1]. It also works to increase the release of dopamine by activating the CB1 receptor in the brain [5].

How To Boost Modafinil’s Effects With Weed

The main stimulatory compound in marijuana is THC.

We recommend finding a weed strain with a moderate-high THC content for these effects.

It’s important to remain conservative with your dosing when mixing a stimulating, high-THC strain of weed with your modafinil. Start with doses that you are familiar with for modafinil. For most people, this is around 200 mg.

Add the weed in slowly. It can help to take weed or weed extracts AFTER the modafinil has peaked, roughly around the 3 or 4-hour mark.

This will help to prolong the peak of the modafinil and will help to prevent becoming too stimulated as the effects of the weed and modafinil build-up at the same time.

If you’re not sure where to start, we recommend Chemdawg, Jack Herer, or Durban Poison as a place to start.

3. Mixing Modafinil & Weed Separately

Many modafinil users also enjoy weed from time to time outside the effects of modafinil.

After taking modafinil during the day, you may choose to settle down with some marijuana in the evening. What many people aren’t aware of, is the fact that there is still likely to be modafinil floating around the bloodstream. This will then interact with the compounds in marijuana even if you didn’t intend for them to mix.

If you’re reading this to find out if it’s safe to combine weed and modafinil, the short answer is yes, but with some caveats.

As mentioned in other sections, the interaction between modafinil and weed is highly variable. It can either make the side effects of the modafinil worse or improve them.

It all depends on the weed strain you use and how much CBD, THC, or other cannabinoids are present in the leaves/flowers.

Understanding the potential interactions is important if you wish to consume modafinil and weed on the same day.

How to Use Modafinil and Weed Separately Without Causing Negative Side Effects

The best way to combine these two compounds is to ensure that your modafinil is taken very early in the morning.

This allows as much of it as possible to be eliminated from the body by the time you sit down to roll up a joint or hit the vape.

Keep in mind what you’re using marijuana for in the first place. If you use it to help you relax after a stimulating day on modafinil, look for a strain with well-known muscle relaxant and sedative qualities.

If you’re looking for the psychoactive qualities of the herb, try using something that is a little more well-rounded, and avoid the high-THC strains.

Taking high THC strains on days where you’re also taking modafinil can result in overstimulation and insomnia.

A few good, well-rounded strains suitable for use with modafinil include Chernobyl, Maui Wowie, or Jack Herer.

Is Mixing Modafinil & Weed Safe?

Now that we know why someone would want to mix weed with modafinil and how to combine them to get the results you’re looking for, you may be wondering, “is mixing modafinil and weed safe?”

A group of researchers set out to find the answer to this question with a study that was published in 2010.

The study took 12 occasional marijuana users and gave them four sessions of 4 different combinations:

  1. THC extract with modafinil
  2. THC with Placebo
  3. Modafinil with Placebo
  4. Placebo with Placebo

All 12 participants were given all combinations four times. They were not told which combination they were receiving each time.

Researchers conducting the study concluded that “modafinil can be safely combined with oral THC” [6].

There have not yet been any comprehensive studies involving raw cannabis or CBD extracts in combination with modafinil, but it is unlikely for there to be any negative interactions.

In summary, modafinil and weed can be combined, and in many ways the combination is beneficial.

However, it’s important to choose the strain cautiously, and understand what your goals are for mixing.

Looking to reduce side-effects of modafinil? — choose a high CBD strain.

Looking to give your modafinil a boost? — choose something high in THC.

Do you want to buy modafnil at a cheap price online? Then we advise you to consider primarily Indian manufacturers with an impeccable reputation.


  1. Fišar, Z. (2010). Inhibition of monoamine oxidase activity by cannabinoids. Naunyn-Schmiedeberg’s archives of pharmacology, 381(6), 563-572.
  2. Volkow, N. D., Fowler, J. S., Logan, J., Alexoff, D., Zhu, W., Telang, F., … & Hubbard, B. (2009). Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. Jama, 301(11), 1148-1154.
  3. Scammell, T. E., Estabrooke, I. V., McCarthy, M. T., Chemelli, R. M., Yanagisawa, M., Miller, M. S., & Saper, C. B. (2000). Hypothalamic arousal regions are activated during modafinil-induced wakefulness. Journal of Neuroscience, 20(22), 8620-8628.
  4. Ishizuka, T., Sakamoto, Y., Sakurai, T., & Yamatodani, A. (2003). Modafinil increases histamine release in the anterior hypothalamus of rats. Neuroscience letters, 339(2), 143-146.
  5. Schlicker, E., & Kathmann, M. (2001). Modulation of transmitter release via presynaptic cannabinoid receptors. Trends in pharmacological sciences, 22(11), 565-572.
  6. Sugarman, D. E., Poling, J., & Sofuoglu, M. (2011). The safety of modafinil in combination with oral∆ 9-tetrahydrocannabinol in humans. Pharmacology Biochemistry and Behavior, 98(1), 94-100.
Author Details

MBBS, MD – Psychiatry, Consultant Psychiatrist

Can I mix modafinil and weed? Is it safe? We go over why this combination makes sense, what the risks are, and how to do it properly to avoid negative side-effects.

Learn the Basics: How to Take Modafinil and Weed Together

Weed is a complex substance.

Its effects can be polar opposite: it can stimulate mental activity and work like a depressant all at once. We can become more productive with the help of weed or completely relaxed instead. It can help us deal with anxiety or, vice versa, enhance it.

It all comes down to picking a suitable kind of weed, because each type has a variety of features. Depending on your choice, it either will cooperate with Modafinil or work against it.

This article is written specifically to help you understand how to take Modafinil with weed effectively and safely.

In addition, we’ll explore some tips and tricks on how to prevent unwanted consequences that come with these substances.

Why Combining Weed With Modafinil?

People decide to mix Modafinil with weed for several reasons.

Someone wants to cut down a certain negative impact that comes with Modafinil. Others want to increase the positive effects of the cognitive enhancer, such as wakefulness and concentration.

It is possible to mix them unintentionally. For example, if you have taken Modafinil before a long studying session or prior to going to work, and some time later you decide to smoke some weed, the two substances might mix in your body.

Is it safe to blend Modafinil and weed? In order to understand this, we will have to find out how these two substances function.

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A Brief Guide on Modafinil

Modafinil is a chemical that influences some processes in our brain. Its main influence is increasing the level of such hormones and neurotransmitters as dopamine, histamine, hypocretin and noradrenaline.

Modafinil promotes the state of wakefulness, sharp concentration, enhanced creativity, etc. Its impact can last from eight to twenty hours approximately. The duration depends on different factors, such as a person’s age, sex, weight, and others.

This cognitive enhancer is extremely useful for boosting productivity. When using it, you can stay focused and work on a project or study for a much longer time than you normally do.

The impact it makes depends heavily on metabolism. The liver is in charge of breaking down substances, which enter our bodies. After Modafinil is metabolized, the compound needs to be filtered through the kidneys. After that, it is washed out with urine.

The better our liver function, the faster it breaks down Modafinil, shortening the duration of its effects. People with liver insufficiency can experience a rise in productivity for significantly longer time.

A Brief Guide on Cannabis

Weed is a colloquial name for cannabis. The various compounds it consists of are called cannabinoids. They resonate with the receptors in the cells of our body, thus affecting it.

Tetrahydrocannabinol and Cannabidiol are the most important cannabinoids. Both of them affect our body, but in different ways.

Understanding Tetrahydrocannabinol (THC)

Generally, THC is more potent than CBD. It promotes appetite and stimulates mental activity.

The amount of THC in marijuana can vary; however, those hybrid kinds with a larger amount of sativa have higher levels of THC.

THC can cause various adverse reactions. Some of them are insomnia, fatigue, problems with coordination, slowed reaction, loss of memory, heart palpitations, etc.

This component works well with Modafinil. One of the adverse reactions of this cognitive enhancer is low appetite, but THC can make it more balanced. It also becomes easier to recover from the impact of the drug.

Pros & Cons of Mixing THC with Modafinil
Pros Cons
Increases appetite suppressed by modafinil Can cause overstimulation and increase side effects like paranoia, irritability, insomnia, or anxiety
Can alleviate the adverse effects of the modafinil come-down Can increase other side effects like dehydration, fidgeting, and dry mouth

Understanding Cannabidiol (CBD)

The influence that CBD has on our system is more calming.

It is used as a pain-relieving medication, which also helps deal with anxiety and relax the tired muscles.

Weed with a high concentration of CBD is beneficial for reducing some of other side effects of Modafinil. These include feeling anxious, experiencing insomnia and headaches.

People also like to combine Modafinil with CBD to enhance the properties of weed.
Indica predominant strain will be perfect for the purpose of enhancing the weed effects. The best way to mix them is to wait until the effects of Modafinil will start to wear off.

Pros & Cons of Mixing CBD with Modafinil
Pros Cons
Alleviates hyperstimulation caused by modafinil, improving side effects like anxiety, paranoia, irritability, insomnia, and anxiety. May further worsen appetite suppression side effects
Can significantly improve insomnia symptoms May reduce the overall impact of modafinil due to some opposing actions

The Reasons to Intermix Modafinil with Weed

1. Minimizing the Negative Spillover Effects of Modafinil With Weed

The majority of users mix these two mainly for this reason.

Modafinil is one of the most popular and powerful nootropics on the market. It is strong enough to make us stay concentrated and awake for as much as twenty hours straight.

On the other hand, it may cause some unwanted adverse reactions. Weed is perfect for decreasing a few of them.

It is worth to remember that weed includes different cannabinoids, the most common of them being CBD and THC. They have different properties and can trigger just the opposite side effects.

The advantages of combining Modafinil with THC include keeping appetite at normal levels, after it was lowered by Modafinil, and relieving some withdrawal consequences of this smart drug.

However, there are certain disadvantages, such as sensory overload, anxiety and insomnia. It can also add to dehydration, which can additionally lead to dry mouth.
CBD has its own pros of being mixed with Modafinil. It relieves sensory overload and helps with anxiety, irritation, delusion, etc. It is especially useful to deal with insomnia.

As for cons, it can enhance the problems with low appetite. It can also decrease the effects of Modafinil in general.

How to Minimize the Consequences of Taking Modafinil with the Help of Weed
In order to reduce certain adverse events, you will have to choose the right strain of weed.

If you want the effect of Modafinil to be less stimulating, pick a strain with a higher CBD concentration. In turn, THC will be beneficial for those who dislike withdrawals after using Modafinil.

Anyway, try not to pick strains with a really high concentration of either substance. You can adjust it later by choosing other weed, if you find it insufficient.

2. Enhancing the Effects of Modafinil with Weed

When someone chooses to lower the impact of Modafinil with the help of weed, others want to bring this cognitive enhancer to a new level.

If the weed you are using has a stimulating effect, as well as Modafinil, be careful and don’t cause overstimulation.

The perfect strain for this purpose will be the one which is high in THC. While Modafinil increases the levels of dopamine, THC is helpful in this case, because it prevents the enzymes responsible for breaking the dopamine down from deterrence. When Modafinil increases the level of dopamine, THC ensures it does not go down.

How to Mix Modafinil and Weed Correctly

The amount of THC in a strain shouldn’t be high. Try aiming at a reasonable amount.

The dosage of Modafinil should also be appropriate for you. The regular dose for the majority of users is 200 mg. People with lower weight and high drug sensitivity might want to decrease the dosage. It is easy to do due to the way Modafinil is manufactured. It comes in pills with a crevasse in the middle, which makes it easy to split the tablet into two 100 mg doses.

The general recommendation is that you take weed after at least a couple of hours upon Modafinil kicking in. This way, the effects of Modafinil will last longer and will not be extremely stimulating.

3. Combining Modafinil with Weed Unintentionally

Modafinil stays in our system for quite a while. Even if you take it in the morning, it may still be in your bloodstream in the evening. Therefore, when someone takes Modafinil before studying or going to work and then decides to smoke marijuana, they are highly likely to mix.

The impact such interaction will have on your body depends on the strain of weed you took. As we’ve already discussed, strains with a high concentration of THC and

CBD can cause different consequences.

If you do not want them to mix at all, try taking Modafinil and weed on separate days.

How to Prevent Unfavorable Adverse Reactions if Weed and Modafinil Blend Unintentionally

If you still want to take them both on the same day, but without causing negative spillover effects, make sure to take Modafinil as early in the morning as possible.
This might give the medicine just enough time to wash out of your body prior to smoking some marijuana. A group of researchers set out to find the answer to this question with a study that was published in 2010.

Remember the purpose of smoking marijuana. If you want to relax, choose the species with relaxing and sedative effects. If you want more stimulation – pick the strains with THC.

Final Thought on Mixing Weed with Modafinil

There has been extensive research done on this matter. It is scientifically proven that combining Modafinil with weed is safe.

There are different possible combinations of weed and Modafinil, depending on the strain of marijuana.

The majority of the side effects of such combination are beneficial if you pick the strain accordingly to your needs.

Weed with a high concentration of CBD is recommended for those who look for calming and relieving anxiety. It is also helpful for treating insomnia.

THC can be the right choice for the people, who want to reverse the low appetite, caused by Modafinil. It also alleviates the withdrawal.

If you choose the weed strain incorrectly, this may result in sensory overload, paranoia, dehydration, suppressed appetite and so on.

In this article, you will learn how to mix Modafinil with weed safely and how to choose the right strains for different purposes.