What Happens When You Mix Caffeine and Marijuana?
With marijuana legalized in an increasing number of states, experts continue to explore its potential benefits, side effects, and interactions with other substances.
The interactions between caffeine and marijuana aren’t totally clear yet. Still, you don’t have to look too hard to find products that already mix caffeine with two key compounds of marijuana, CBD and THC.
Read on to learn more about how caffeine can interact with marijuana and the potential side effects and risks of combining the two.
Research on the interaction between caffeine and marijuana is still in the early stages, but so far, it seems that consuming the two together may produce different effects than using them separately.
Caffeine generally acts as a stimulant, while marijuana can act as either a stimulant or a depressant. In other words, using caffeine tends to energize most people. The effects of marijuana can vary, but many people use it to feel more relaxed.
It may seem possible, then, that caffeine might cancel out the effects of marijuana, or vice versa. For example, maybe smoking a little weed could help counteract coffee jitters. But so far, there’s no evidence to support that the two counteract each other in any way.
While there’s no evidence to suggest that marijuana and caffeine simply cancel each other out, two animal studies suggest that mixing the two may enhance some of marijuana’s effects.
A different ‘high’
A 2014 study looked at squirrel monkeys who had been given THC, the compound in marijuana that produces the high. The monkeys had the option to keep receiving more THC.
Researchers then gave them different doses of MSX-3, which produces effects similar to those of caffeine. When given low doses of MSX-3, the monkeys gave themselves less THC. But at high doses, the monkeys gave themselves more THC.
This suggests that low levels of caffeine may enhance your high so you don’t use as much. But high levels of caffeine could affect your high in the opposite way, leading you to use more marijuana.
More research as needed, as this small study was conducted only on animals, not humans.
Caffeine helps many people feel more alert. You might drink coffee, tea, or energy drinks every morning to help you wake up, or just to help increase your concentration when you feel tired or less focused than usual.
Some people also find caffeine helps improve working memory. Marijuana, on the other hand, is known for its less desirable effect on memory. Again, you’d think the two would balance each other out, but that doesn’t seem to be the case.
A 2012 study looking at how a combination of caffeine and THC affected memory in rats. The results suggest that a combination of caffeine and a low dose of THC seemed to impair working memory more than a higher dose of THC would on its own.
Remember, this study was only done using rats, so its unclear how these results translate in humans. Still, it does suggest that caffeine may increase the effects of THC.
So far, there haven’t been any reported cases of extreme risks or side effects of combining caffeine and marijuana. But that doesn’t mean they don’t exist.
Plus, people can have varying reactions to both caffeine and marijuana. If you do try mixing the two, make sure you first understand how your body reacts to each one individually. If you’re sensitive to marijuana, for example, combining it with caffeine might result in an unpleasantly strong high.
If you do decide to mix marijauna and caffeine, follow these tips to help you avoid a bad reaction:
- Start small. Start with small amounts of both, less than you would typically consume of each individually.
- Go slow. Give your body plenty of time (at least 30 minutes) to adjust to the combination before having more of either substance.
- Pay attention to usage. It might sound like overkill, but it’s easy to lose track of how much caffeine or marijuana you’ve had, especially when mixing the two.
There are serious side effects that can come from ingesting very high doses of caffeine, from high blood pressure to rapid heart rate. There have also been deaths related to ingesting large amounts of caffeine, though researchers noted that the deceased took caffeine pills or powder, not caffeinated drinks.
Above all, make sure to listen to your body and mind. If you experience unusual symptoms after mixing the two, reach out to a healthcare provider for guidance. You likely aren’t in any great danger, but the combination of caffeine’s heart-racing effects and marijuana’s tendency to cause anxiety in some people can be a recipe for panic.
Caffeine and marijuana are an increasingly popular combo, but there are some potential interactions to be aware of. Learn how to avoid a bad time and stay safe.
6 Conditions That Marijuana Can Mimic
Rod Brouhard is an emergency medical technician paramedic (EMT-P), journalist, educator, and advocate for emergency medical service providers and patients.
Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital.
Marijuana is touted as the safest of all recreational drugs. There is considerable debate about that, but the good news is that deaths from marijuana only are rarely reported. Marijuana used in conjunction with other drugs, however, is a much bigger problem. Even alcohol potentiates the effects of weed significantly. After hearing how mellow marijuana is supposed to be, many folks who try it for the first time are surprised by their reactions.
As drugs go, especially naturally occurring drugs, marijuana is one of the most complicated. Made from the cannabis plant, it contains more than 113 active ingredients, called cannabinoids. These cannabinoids all affect the body in some way, and not always in the same way. Those who are well versed in the different choices have the ability to choose the sort of high they want.
Those who are new to the scene, however, can be surprised by the reaction they feel. There are plenty of stories of folks trying weed for the first time—or more precisely, the first time since college—and discovering that the high isn’t exactly what they expected. A quick internet search will find a bevy of 911 calls from people who didn’t quite enjoy the high they were feeling.
More Harsh Than Mellow
Some people go to the hospital thinking they’ve had a medical emergency.
The various psychoactive substances in marijuana are likely to create all sorts of different reactions to its consumption and even the way the drug is consumed makes a difference.
Eating a marijuana brownie metabolizes the weed differently than smoking a joint, which means the same bud could have different effects when eaten than it does when smoked. It also takes longer to feel the effects after ingesting the drug than it does after smoking it, which often leads newcomers to eat too much, thinking they aren’t getting anywhere. When the weed starts kicking in, it comes on all at once.
The two most well-known cannabinoids in pot are tetrahydrocannibinol (THC) and cannabidiol (CBD). Medical authorities aren’t entirely sure how each works exactly, but it’s generally believed that the paranoia and anxiety produced by THC are partly offset by the anti-anxiety properties of CBD. Some people are using CBD extract medicinally for things like seizure control and anxiety reduction with some success. Other folks go for the most extreme concentrations of THC they can find, which leads to a high that looks more like that of a stimulant than the sedative most people expect marijuana to be.
To meet the demand, modern marijuana farmers are very good at improving their yields. The same advances in agriculture that have increased food production per acre—and even per plant—around the world have also increased the concentration of THC in weed. THC in confiscated cannabis samples increased from 3.4% in 1993 to 8.8% in 2008. On top of that, there are other forms of marijuana besides the usual bud. Hash oil, sometimes called butane honey oil or BHO, is known for being extremely potent, up to 80% THC. The more THC in the product, the more anxiety, and stimulant-like reaction can be expected.
Not only is there great agricultural advances pushing the limits of farming efficiency, but there are also synthetic copies of marijuana. K2 or Spice are examples of synthetic cannabinoid compounds that mimic the effects of natural weed and act on the same cannabinoid receptors in the body. It sounds great to say we can make weed instead of growing it, but the reality is that you really don’t know what you’re getting. Beyond the fact that weed can mimic certain medical conditions, synthetic cannabinoids might have other drugs either as part of their chemical make-up or can be laced with other drugs to enhance their effects.
Can Weed Feel Like a Heart Attack?
With well over a hundred more cannabinoids in the marijuana compound besides THC and CBD, there’s a whole lot we don’t know about how weed affects the body. Because of the fact that it gets you high, scientists have focused on the effects of marijuana on the brain and central nervous system. But, evidence shows that weed also affects the heart.
There are several documented cases of marijuana causing heart rhythm disturbances and even one death through a fatal arrhythmia. It’s very possible these people could have had pre-existing cardiac conditions, even if they didn’t know it, but the weed certainly affected the way their hearts were functioning while they were high. In at least one case of atrial fibrillation, the effect persisted after the high wore off.
With the cardiac effects of marijuana largely still not well understood, the fact that some folks may feel as if they are having a heart attack after consuming weed is not to be ignored. Marijuana dulls pain; in fact, it’s one of the many benefits touted for medicinal use. So, even if the weed is affecting the heart in a negative way that could lead to chest pain when sober, people might not feel the pain. You can’t ignore feelings of distress, including palpitations or chest pressure, when taking marijuana. The fact is, it might not be mimicking a heart attack so much as causing one.
Weed slows down your mental processes. It’s one of the main parts of marijuana that users remember (well, if you can remember anything). It’s that slow, gentle, absentmindedness that is the butt of so many pot jokes.
Imagine a person with diabetes smoking a little weed and having someone visit. The slow, halting movements and difficulty finding words are exactly what you’d expect to see during a bout of low blood sugar. Just don’t reach for the pot brownies to help fix the problem.
Is All That Vomiting From Pot or Gastroenteritis?
Pot makes some folks vomit. It even has a name: cannabinoid hyperemesis. Typically associated more with chronic marijuana use, cannabinoid hyperemesis leads to severe, uncontrollable vomiting. Some people have discovered that hot showers can reduce nausea temporarily, but the only surefire way to completely stop the condition is to stop smoking weed.
Not a lot is known about cannabinoid hyperemesis. While it is known to affect chronic tokers, uncontrollable vomiting has been documented in other examples of folks who simply took a lot of marijuana. There is a debate about whether or not you can actually overdose on weed, but the medical community generally agrees there is such a thing as marijuana poisoning. Vomiting is one of the effects that gets mentioned often.
For folks who start vomiting after smoking marijuana, the presence of vomiting while high could be easily mistaken for some infection or gastroenteritis. It’s very important to be honest about the use of cannabis. Those around the patient are going to have a really hard time identifying the cause of nausea unless they are aware of the patient’s marijuana consumption. This is particularly bad news for the folks who started smoking weed to treat their nausea, common use by chemotherapy patients.
Besides vomiting, pot is also known for causing a fair amount of heartburn among those who use it the most. There are a few options that chronic users can take to try to calm their indigestion, but the only guaranteed cure is to stop smoking.
While most panic attacks are psychiatric in nature, weed can definitely push the panic button. It’s not unheard of to see patients hyperventilating and scared of nothing in particular when high. Unfortunately, like many other adverse reactions of marijuana, time is the only cure. There isn’t an antidote on the market that will reverse the effects of marijuana. Indeed, for those who are susceptible to the panicky feelings that weed might produce, abstinence is the only option.
THC’s anxiety-inducing properties are notorious. Even in the past, when the amount of THC in a joint was nowhere near as potent as today, some folks didn’t like the way weed made them feel as if the police were coming any minute. The anxiety felt by consuming a drug that was unequivocally illegal was probably worse than in today’s more tolerant environment. Whatever the barriers to marijuana use that have been removed, however, are probably offset by the potency of the product.
One step beyond panic is paranoia. It’s a fine line, but when weed takes you there, it might not bring you back. Psychosis that is induced by marijuana doesn’t always subside when the pot is all metabolized in some vulnerable individuals. In most cases of THC-induced psychosis, cessation of use is the eventual cure, but there are examples of marijuana being the trigger of longer-term psychotic symptoms.
This is one reason to definitely stay away from the highest concentrations of THC. Whether you choose to use or not, pushing the THC limit can be a dangerous game.
Marijuana is a complicated drug with lots of different faces. We don't yet know everything that it can do or all of its dangers.