POOR CBD BIOAVAILABILITY – THE MOST PRACTICAL SOLUTION. CBD really is worth all of the hype, but it has a quirk! When occurring naturally in hemp oil, or simply extracted from it, CBD has poor bioavailability in humans , especially when consumed orally due to challenges with absorption in the gut and extensive metabolism by the liver. The dose which reaches general circulation can be as low as 6% of the amount that you consumed,  ,  which is a big issue when supplementing with CBD and wanting to see results!
One solution is to administer large oral dosages to increase the chance that enough will reach circulation to exert a benefit. This is the approach taken by most researchers, as you can see from the research referenced above. An alternative solution is to administer lower oral dosages of a more bioavailable form of CBD which harnesses the power of cutting-edge liposomal technology . This type of CBD may be 4x better absorbed than other oils and have an up to 3x longer-lasting effect.  The beauty of delivering CBD with superior bioavailability means that a lower daily dosage of CBD can have maximum effect . In fact, if liposomal CBD is around 4x better absorbed than standard, a 10mg daily dosage of liposomal CBD may deliver the biological activity of 40mg straight CBD, so it’s a far smarter way of supplementing CBD. Our view is that this latter solution is the most practical and cost-effective way of supplementing with CBD in a real-life setting. If you are keen to discuss CBD, we encourage you to call or email our Clinical Nutrition team who are here to support you.
The brand you can talk to: We have a team of Nutritionists at the end of our advice line, open to you, for product support and advice (5 days a week). You can register now to receive up to date news, product information and exclusive offers whether you are a consumer, practitioner or retailer. An introduction to the endogenous cannabinoid system. Cannabinoid receptors in the central nervous system: their signaling and roles in disease. The pharmacology of cannabinoid receptors and their ligands: an overview. Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. Translational investigation of the therapeutic potential of cannabidiol (CBD): toward a new age. The therapeutic role of cannabidiol in mental health: a systematic review. Review of the neurological benefits of phytocannabinoids. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors. Inverted U-shaped dose-response curve of the anxiolytic effect of cannabidiol during public speaking in real life. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Cannabidiol in anxiety and sleep: a large case series. Cannabidiol as a potential treatment for psychosis. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizoprenia. Effect of cannabidiol on medial temporal, midbrain, and striatal dysfunction in people at clinical high risk of psychosis: a randomised clinical trial. Effects of acute cannabidiol administration on anxiety and tremors induced by a simulated public speaking test in patients with Parkinson’s disease. Cannabidiol protects dopaminergic neuronal cells from cadmium. Cannabidiol to improve mobility in people with multiple sclerosis. Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress. From Cannabis sativa to cannabidiol: promising therapeutic candidate for the treatment of neurodegenerative diseases. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Is the cardiovascular system a therapeutic target for cannabidiol?
Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Evaluation of the effects of CBD hemp extract on opiod use and quality of life indicators in chronic pain patients: a prospective cohort study. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Available at:https://www.who.int/medicines/access/controlled-su. Human metabolites of Cannabidiol: a review on their formation, biological activity, and relevance in therapy. A novel self-emulsifying drug delivery system (SEDDS) based on VESIsorb ® formulation technology improving the oral bioavailability of cannabidiol in healthy subjects. Please visit us at our new location at 44984 Hwy 17 North. We offer a full service pharmacy, staffed by licensed Pharmacist. Along with filling your Prescriptions, we also offer health and personal items.
We are also here to help you with questions about your medications and how they affect you. Drive-Thru Window at the pharmacy for your convenience.