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There is some research showing that overweight women who take a specific product containing a combination of extracts of magnolia plus phellodendron don't gain as much weight as other women. They seem to eat fewer calories, possibly because the magnolia reduces their stress-related eating. But there is no reliable evidence that taking this product actually causes weight loss. More evidence is needed to rate the effectiveness of magnolia for these uses.

Special Precautions & Warnings: Pregnancy and breast-feeding : Taking magnolia flower bud by mouth is UNSAFE during pregnancy. There are reports that magnolia can cause the uterus to contract and that might cause a miscarriage. Not enough is known about the safety of using magnolia bark during pregnancy. Not enough is known about the safety of using magnolia during breast-feeding. Surgery : Magnolia can slow down the central nervous system. There is a concern that it might slow down the nervous system too much when combined with anesthesia and other medications used during and after surgery. Magnolia might also slow blood clotting and cause bleeding during and after surgery. Stop using magnolia at least 2 weeks before a scheduled surgery. Magnolia bark might also cause sleepiness and drowsiness.

Taking large amounts of magnolia bark along with alcohol might cause too much sleepiness. Sedative medications (Barbiturates) interacts with MAGNOLIA. Magnolia bark might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking magnolia bark along with sedative medications might cause too much sleepiness. Some sedative medications include amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), and others. Sedative medications (Benzodiazepines) interacts with MAGNOLIA. Magnolia bark might cause sleepiness and drowsiness. Drugs that cause sleepiness and drowsiness are called sedative medications. Taking magnolia bark along with sedative medications might cause too much sleepiness. Do not take magnolia bark if you are taking sedative medications. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. Sedative medications (CNS depressants) interacts with MAGNOLIA. Magnolia bark might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking magnolia bark along with sedative medications might cause too much sleepiness. Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. The following doses have been studied in scientific research: APPLIED TO THE SKIN: For gingivitis : A toothpaste containing 0.3% magnolia has been used twice daily. Chewing gum containing magnolia bark extract 0.17% and xylitol 30% has been chewed for 5 minutes three times daily for 30 days. The effect of zinc lactate and magnolia bark extract added tablets on volatile sulfur-containing compounds in the oral cavity. The effect of zinc acetate and magnolia bark extract added to chewing gum on volatile sulfur-containing compounds in the oral cavity.

Raison-Peyron N, CГ©saire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Schifano F, Guarino V, Papanti DG, Baccarin J, Orsolini L, Corkery JM. Is there a potential of misuse for Magnolia officinalis compounds/metabolites? Effect of Silymarin Administration on Cisplatin Nephrotoxicity: Report from A Pilot, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.

Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Effect of Magnolia officinalis and Phellodendron amurense (ReloraВ®) on cortisol and psychological mood state in moderately stressed subjects. Magnolol stimulates steroidogenesis in rat adrenal cells. UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss.

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