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Bupropion SR worsens mood during marijuana withdrawal in humans

Affiliation

  • 1 Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York 10032, USA. [email protected]
  • PMID: 11401006
  • DOI: 10.1007/s002130000657

Bupropion SR worsens mood during marijuana withdrawal in humans

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Authors

Affiliation

  • 1 Division on Substance Abuse, New York State Psychiatric Institute, College of Physicians and Surgeons of Columbia University, New York 10032, USA. [email protected]
  • PMID: 11401006
  • DOI: 10.1007/s002130000657

Abstract

Rationale: Symptoms of withdrawal after daily marijuana smoking include increased ratings of irritability and depression. Similar mood symptoms are reported by cigarette smokers during nicotine abstinence.

Objective: Given the successful use of sustained-release bupropion in treating nicotine dependence, this study investigated how maintenance on bupropion influenced symptoms of marijuana withdrawal compared to maintenance on placebo.

Methods: Marijuana smokers (n=10) were maintained outpatient on active (300 mg/day) or placebo (0 mg/day) bupropion for 11 days, and were then maintained inpatient on the same bupropion dose for 17 days. For the first 4 inpatient days, participants smoked active marijuana [2.8% delta9-tetrahydrocannabinol (THC)] 5 times/day. For the remaining inpatient days, participants smoked placebo marijuana (0.0% THC) 5 times/day. Participants were then maintained outpatient on the alternate dose of bupropion for 11 days, followed by a second inpatient residential stay, paralleling the first. Medication administration was double-blind. Mood, psychomotor task performance, food intake, and sleep were measured daily during each inpatient phase. The order of active and placebo bupropion maintenance was counterbalanced between groups.

Results: Bupropion had few behavioral effects when participants smoked active marijuana. During placebo marijuana smoking, i.e., active marijuana withdrawal, ratings of irritability, restlessness, depression, and trouble sleeping were increased by bupropion compared to placebo maintenance.

Conclusions: These data suggest that bupropion does not show promise as a potential treatment medication for marijuana dependence.

These data suggest that bupropion does not show promise as a potential treatment medication for marijuana dependence.

Drug Interactions between cannabis and Wellbutrin XL

This report displays the potential drug interactions for the following 2 drugs:

  • cannabis
  • Wellbutrin XL (bupropion)

Interactions between your drugs

No interactions were found between cannabis and Wellbutrin XL. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

cannabis

A total of 377 drugs are known to interact with cannabis.

  • Cannabis is in the drug class illicit (street) drugs.
  • Cannabis is used to treat the following conditions:
    • AIDS Related Wasting
    • Muscle Spasm
    • Nausea/Vomiting, Chemotherapy Induced
    • Pain

Wellbutrin XL

A total of 420 drugs are known to interact with Wellbutrin XL.

  • Wellbutrin xl is in the drug class miscellaneous antidepressants.
  • Wellbutrin xl is used to treat the following conditions:
    • Depression
    • Major Depressive Disorder
    • Seasonal Affective Disorder

Drug and food interactions

buPROPion food

Applies to: Wellbutrin XL (bupropion)

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures during treatment with buPROPion. If you are prone to frequent or excessive alcohol use, talk to your doctor before starting buPROPion. In general, you should avoid or limit the use of alcohol while being treated with buPROPion. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

cannabis (Schedule I substance) food

Applies to: cannabis

Alcohol can increase the nervous system side effects of cannabis (Schedule I substance) such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cannabis (Schedule I substance). Do not use more than the recommended dose of cannabis (Schedule I substance), and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See Also

  • Cannabis Drug Interactions
  • Wellbutrin XL Drug Interactions
  • Wellbutrin XL General Consumer Information
  • Drug Interactions Checker
Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some mixtures of medications can lead to serious and even fatal consequences.

View drug interactions between cannabis and Wellbutrin XL. These medicines may also interact with certain foods or diseases.