What You Need To Know About CBD If You Take Antidepressants
ThereвЂ™s no denying that CBD, aka cannabidiol, was the reigning trend of last year, and shows no signs of stopping. From edible products and tinctures, to bath and beauty products, CBD was (and is) everywhere. Though touted as a natural, holistic, and safe way to manage a variety of health issues, you may be wondering if you can take CBD and antidepressants together. And while CBD is touted as an all-natural supplement with some evidence that it can be good for your health, it’s possible that your CBD latte can still impact the efficacy of different medications вЂ” including antidepressants.
According to statistics from the National Alliance on Mental Illness (NAMI), one in five U.S. adults live with a mental illness in any given year. Furthermore, as NBC News reported, a 2016 study revealed one in six people in the U.S. take some type of psychiatric medication, with antidepressants being the most widely prescribed. Limited research has shown that CBD may help alleviate symptoms of anxiety and sleep issues, as well as lower levels of inflammation in the body, though this research (and the dosages needed for these effects) is nowhere near conclusive. And that means you need to be careful if you’re choosing to consume it.
вЂњGenerally speaking, you can safely use CBD supplements when youвЂ™re taking antidepressants. However, there are a couple concerns,вЂќ Peter Grinspoon, M.D., an instructor in medicine at Harvard Medical School, and the author of the memoir Free Refills: A Doctor Confronts His Addiction, tells Bustle. вЂњThe first concern is that CBD isnвЂ™t regulated by the FDA. You have to be careful that the CBD youвЂ™re getting is from a reliable supplier. For example, Consumer Reports recently put out an article on how to go shopping for CBD because theyвЂ™ve done tests, and found some [supplement] formulations had no CBD. Some were inaccurately labeled, and other formulations even had some THC in them.вЂќ (THC is the cannabis compound that, unlike CBD, can get you high.)
The recent passing of the bipartisan Farm Bill legalized the production of hemp on an industrial scale for the first time in the U.S. вЂ” which means itвЂ™s that the CBD industry will only continue to grow. However, this doesnвЂ™t necessarily mean there will be more oversight or required research.
So, what can potentially happen if you take CBD when on antidepressants? Unfortunately, because thereвЂ™s a limited amount of studies to draw from, Grinspoon says, вЂњCBD does have hypothetical drug interactions; the question is whether these are clinically important or not.вЂќ
The reason for this is that CBD inhibits two main enzyme systems, Grinspoon explains. Enzymes are proteins that speed up chemical reactions in the body, and play an important role in functions like digestion and respiration. They also help you metabolize antidepressants. вЂњOne system is the same one that grapefruit inhibits вЂ” the technical name is the CYP34A enzyme system. So, just like grapefruit juice, CBD can cause your body to have higher doses of benzodiazepines [anti-anxiety medications], or certain antipsychotic medications,вЂќ Grinspon explains.
WhatвЂ™s more, Grinspoon says that CBD also inhibits вЂњthe system that metabolizes a lot of serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and antipsychotics as well.вЂќ Meaning, taking CBD supplements while on these psychiatric medications could hypothetically interfere with how these medications are metabolized.
Despite this, Grinspoon explains that this is typically not a large cause of concern for a majority of people on antidepressants or other psychiatric medications. вЂњCertainly, if someone is on a very delicately balanced medical regiment, CBD could knock that out of whack because of the two different enzyme systems it inhibits. In terms of actual clinical practice, I havenвЂ™t heard any stories of people having clinical decompensation because of adding CBD to their regime,вЂќ he says.
When it comes down to it, Grinspoon says that the potential interactions should be regarded as more вЂњhypothetical than real,вЂќ and that the side effect profile of CBD is вЂњvery minimal.вЂќ Of course, itвЂ™s always good to have a conversation with your physician about potential interactions, and to disclose any prescribed or over-the-counter medications and supplements you are taking. At the end of the day, using CBD supplements while on antidepressants is an individual choice, but it’s important to go in informed.
Readers should note that the regulations and data surrounding marijuana, CBD, and other related products are still developing. As such, the information contained in this post should not be construed as medical or legal advice. Always consult with your doctor before trying any substance or supplement.ThereвЂ™s no denying that CBD, aka cannabidiol, was the reigning trend of last year, and shows no signs of stopping. From edible products and tinctures, to bath and beauty products, CBD was (and is) everywhere. Though touted as a natural, holistic,вЂ¦
Drug Interactions between cannabidiol and Zoloft
This report displays the potential drug interactions for the following 2 drugs:
- Zoloft (sertraline)
Interactions between your drugs
Applies to: Zoloft (sertraline) and cannabidiol
Using sertraline together with cannabidiol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
Applies to: Zoloft (sertraline)
You should avoid or limit the use of alcohol while being treated with sertraline. Alcohol can increase the nervous system side effects of sertraline such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. Talk to your doctor or pharmacist if you have any questions or concerns.
Applies to: cannabidiol
Food may affect the absorption and blood levels of cannabidiol. To avoid significant fluctuations in blood levels of the medication, cannabidiol should be taken about the same time each day consistently either with or without food. Consumption of grapefruit and grapefruit juice should be limited, as it may increase the blood levels of cannabidiol. Patients who consume grapefruit or grapefruit juice may require a lower dosage of the medication based on blood levels. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
- Cannabidiol Drug Interactions
- cannabidiol General Consumer Information
- Zoloft Drug Interactions
- Zoloft General Consumer Information
- Drug Interactions Checker
Drug Interaction Classification
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|Unknown||No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some mixtures of medications can lead to serious and even fatal consequences.A Moderate Drug Interaction exists between cannabidiol and Zoloft. View detailed information regarding this drug interaction. ]]>